Active Structural Acoustic Control (ASAC) is an effective method for sound radiation control. To solve the coupling effect or inconvenience problems existed in the application of conventional methods, by utilizing the characteristic of intuitive representation of radiated sound power through force radiation modes, the control forces are designed to make the total excitation force vector orthogonal to each dominant force radiation mode. Therefore, an ASAC method by utilizing force radiation modes is proposed, and detailed theoretical research and numerical calculation analysis are carried out. The research results indicate that the control force requirement can be intuitively obtained through the force radiation modes, and decoupled control of radiated sound power corresponding to each force radiation mode is achieved by the proposed method. Thus, the control strategy and system construction can be greatly simplified, and structural acoustic radiation can be effectively controlled.