Active Surveillance of Influenza A and Other Respiratory Viruses in Children with Influenza-like-illness in Two Seasons

Girit, Saniye; Karaaslan, Ayşe; Gençer, Serap; Yılmaz, Emel; Ayhan, Yetkin; Vayvada, Elif Ruşen; Cıblak, Meral A.; Badur, Selim; Akın, Yasemin

doi:10.3855/jidc.8867

Cited by 2 publications

(1 citation statement)

References 14 publications

(14 reference statements)

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“…Despite systematic efforts, the influenza burden in Mexico remains high [4]. The SARS-CoV-2 and the influenza virus have common mechanisms of spread, and children and teenagers play a major role in flu transmission [5,6]. We aimed to evaluate the impact of physical distancing interventions on the incidence of influenza-like illness (ILI) and severe acute respiratory infection (SARI) [7], as a proxy of the impact on SARS-CoV-2 spread.…”

Section: Introductionmentioning

confidence: 99%

Physical distancing reduced the incidence of influenza and supports a favorable impact on SARS-CoV-2 spread in Mexico

Murillo-Zamora

Guzmán-Esquivel

Sánchez-Piña

et al. 2020

J Infect Dev Ctries

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Introduction: Physical distancing preventive measures were implemented in Mexico as a response to the coronavirus disease 2019 (CoViD-19) pandemic. School closures occurred on March 16, 2020, in 10 out of 32 Mexican states, and one week later in the remaining states. Because the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the influenza virus have similar transmission mechanisms, we aimed to evaluate the impact of physical distancing on the incidence of influenza as a proxy of the impact on SARS-CoV-2 contagion. Methodology: A national flu surveillance system was cross-sectionally analyzed and daily average percent changes (APCs) of incidence rates were calculated throught Poisson regression models. Results: Greater decreasing trends (APCs -8.8, 95% CI: -12.5, -4.5; vs. -6.0, 95% CI: -9.9, -2.0; p = 0.026) were documented in the states with earlier school closures and across age groups, suggesting that earlier implementation of physical distance results in reduced SARS-CoV-2 spread. Conclusions: Physical distancing policies decrease the incidence of influenza infections in Mexico; its favorable impact on the spread of SARS-CoV-2 is commendable.

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Section: Introductionmentioning

confidence: 99%

Physical distancing reduced the incidence of influenza and supports a favorable impact on SARS-CoV-2 spread in Mexico

Murillo-Zamora

Guzmán-Esquivel

Sánchez-Piña

et al. 2020

J Infect Dev Ctries

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Real-world effectiveness and safety of Baloxavir Marboxil or Oseltamivir in outpatients with uncomplicated influenza A: an ambispective, observational, multi-center study

Cai,

Wang,

et al. 2024

Front. Microbiol.

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IntroductionBaloxavir Marboxil is a per oral small-molecule antiviral for the treatment of influenza. While the efficacy and safety of Baloxavir Marboxil have been thoroughly characterized across an extensive clinical trial, studies on the effectiveness of Baloxavir Marboxil in a real-world setting are still scarce.MethodsWe conducted an ambispective, observational, multi-center study that enrolled uncomplicated in-fluenza outpatients treated with Baloxavir Marboxil or Oseltamivir in East China. The primary endpoint was time from treatment to alleviation of all influenza symptoms (TTAIS). The secondary endpoints included time from treatment to alleviation of fever (TTAF) and household transmission during the duration of influenza.ResultsA total of 509 patients were enrolled. The median TTAIS in the Baloxavir Marboxil group and the Oseltamivir group was 28.0 h (IQR, 20.0 to 50.0) and 48.0 h (IQR, 30.0 to 67.0), respectively. The median TTAF in the Baloxavir Marboxil group and the Oseltamivir group was 18 h (IQR, 10.0–24.0) and 30.0 h (IQR, 19.0–48.0). In the COX multivariable analysis, Baloxavir Marboxil reduced the duration of influenza symptoms (HR = 1.36 [95%CI:1.12–1.64], p = 0.002) and the duration of fever (HR = 1.93 [95%CI:1.48–2.52], p < 0.001) compared to Oseltamivir. When antiviral drugs were given within 12–48 h after symptom onset, the Baloxavir Marboxil group had a significantly shorter TTAIS compared to the Oseltamivir group. There was no significant difference in the rate of adverse events between the two group (p = 0.555).DiscussionBaloxavir Marboxil was superior to Oseltamivir in alleviating influenza symptoms in outpatients with uncomplicated influenza. Our findings suggested that compared to Oseltamivir, Baloxavir Marboxil might be more appropriate for patients with influenza 12– 48 h after symptom onset.

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Active Surveillance of Influenza A and Other Respiratory Viruses in Children with Influenza-like-illness in Two Seasons

Cited by 2 publications

References 14 publications

Physical distancing reduced the incidence of influenza and supports a favorable impact on SARS-CoV-2 spread in Mexico

Physical distancing reduced the incidence of influenza and supports a favorable impact on SARS-CoV-2 spread in Mexico

Real-world effectiveness and safety of Baloxavir Marboxil or Oseltamivir in outpatients with uncomplicated influenza A: an ambispective, observational, multi-center study

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