2019
DOI: 10.22270/jddt.v9i1-s.2356
|View full text |Cite
|
Sign up to set email alerts
|

Active targeting of nanoparticles: An innovative technology for drug delivery in cancer therapeutics

Abstract: In nanomedicines, currently a wide array of reported nanoparticle systems is being explored by targeting schemes which suggests great potential of targeted delivery to revolutionize cancer therapeutics. This review  gives insight into recent  challenges in modification of nanoparticle systems for enhanced cancer therapy  acknowledged by researchers to date and also outlines different major targeting strategies of nanoparticle systems that have been utilized for the delivery of therapeutics or imaging agents, t… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
9
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 17 publications
(9 citation statements)
references
References 32 publications
0
9
0
Order By: Relevance
“…Various types of targeting moieties have been employed to actively target NPs to cancer cells including; antibodies, antibody fragments, aptamers, transferrin and others 9 . The use of a certain targeting ligand depends on the prevalence of particular receptors on their surface.…”
mentioning
confidence: 99%
“…Various types of targeting moieties have been employed to actively target NPs to cancer cells including; antibodies, antibody fragments, aptamers, transferrin and others 9 . The use of a certain targeting ligand depends on the prevalence of particular receptors on their surface.…”
mentioning
confidence: 99%
“…In the nanosystems, physicochemical properties of bare nanoparticles, such as morphology, size, charge, and chemical composition, among others, determine their unique properties (optic, magnetic, luminescent, reactivity, ratio, surface–volume ratio, surface plasmon effect (SPR), etc. ), while the ligands contribute to their colloidal stability (via electrostatic and/or steric interactions) and function (active targeting by specific affinity for the cell surface in cancer cells), and therefore, to the final size, shape, properties, and behavior ( Table 1 ) [ 16 , 17 , 18 , 19 ].…”
Section: Hallmarks Of Nanoparticle Systemsmentioning
confidence: 99%
“…The structure of a liposome is described as a vesicle consisting of lipid bilayers that mimic cellular membranes. However, this similarity to cell membranes (without surface functionalization or conventional formulations) allows them to be rapidly captured by the mononuclear phagocytic system [ 16 , 19 ]. Due to the chemical and structural composition of the liposomes, one of their main functions is to serve as drug-delivery systems.…”
Section: Liposomesmentioning
confidence: 99%
“…Several drug carrier technologies such as microencapsulation, liposome, and nanoparticle formulations inherently enhance the stability and control the release of mAbs, which can prolong their half-life. These nanocarrier formulation strategies are of intense interest, as they hold promise for developing less invasive inhaled formulations of mAb-based therapeutics with superior attributes to currently established formulations [41,106,107,108,109].…”
Section: Formulation Strategies and Considerationsmentioning
confidence: 99%