Active transforming growth factor-β1 activates the procollagen I promoter in patients with acute lung injury

Budinger, G. R. Scott; Chandel, Navdeep S.; Donnelly, Helen K.; Eisenbart, James; Oberoi, Monica; Jain, Manu

doi:10.1007/s00134-004-2503-2

Cited by 67 publications

(59 citation statements)

References 46 publications

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“…Consistent with this, the active pool of TGF-␤1 in patients with idiopathic pulmonary fibrosis, ranges from 17.6% in the upper lobe to 78.4% in the lower lobe (24). Active TGF-␤1 has been detected in BALs from patients with ARDS using bioactivity assays (6,12). However, the extent of activation was not determined in these studies.…”

Section: Discussionmentioning

confidence: 73%

The relative balance of GM-CSF and TGF-β1 regulates lung epithelial barrier function

Overgaard

Schlingmann

White

et al. 2015

American Journal of Physiology-Lung Cellular and Molecular Phys

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Section: Discussionmentioning

confidence: 73%

The relative balance of GM-CSF and TGF-β1 regulates lung epithelial barrier function

Overgaard

Schlingmann

White

et al. 2015

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…[10][11][12] Analogous observations have been reported in mechanically ventilated patients with ARDS. [13][14][15] Although large clinical trials have reassured clinicians that a low V t strategy 1 and judicious use of positive end-expiratory pressure (PEEP) 16,17 promote improved short-term outcomes in ARDS, including survival, their effects on early development of fibroproliferation remain unclear. Importantly, recent investigations using chest CT scanning have suggested that lung inhomogeneities typical of ARDS function as "stress raisers" that may locally increase the susceptibility to ventilatorinduced lung injury from externally applied pressure or volume, 18 highlighting the need to further delineate and characterize the eff ects of mechanical ventilation on ARDS pathophysiology.…”

Section: Subjects Examinedmentioning

confidence: 99%

Detection of Fibroproliferation by Chest High-Resolution CT Scan in Resolving ARDS

Burnham

Hyzy

Paine

et al. 2014

Chest

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BACKGROUND:In ARDS, the extent of fibroproliferative activity on chest high-resolution CT (HRCT) scan has been reported to correlate with poorer short-term outcomes and pulmonaryassociated quality of life. However, clinical factors associated with HRCT scan fi broproliferation are incompletely characterized. We questioned if lung compliance assessed at the bedside would be associated with fi broproliferation on HRCT scans obtained during the resolution phase of ARDS.

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“…It is now recognized that these processes occur simultaneously in the lungs of patients with ARDS (5). Previous studies have indicated that changes in various cytokines such as platelet-derived growth factor (PDGF) and transforming growth factor (TGF) are involved in these processes (6,7). Therefore, understanding the changes in the cytokines in these processes may provide possible opportunities for therapeutic intervention of ARDS.…”

Section: Introductionmentioning

confidence: 99%

Changes in factor VII-activating protease in a bleomycin-induced lung injury rat model and its influence on human pulmonary fibroblasts in vitro

Liu²,

Chen³

et al. 2010

Int J Mol Med

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Abstract. Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by non-cardiogenic pulmonary edema, respiratory distress and hypoxemia. Factor VII-activating protease (FSAP) is a plasma-derived protease which inhibits the proliferation and migration of hepatic stellate cells and vascular smooth muscle cells. This study was designed to determine the dynamic expression changes in FSAP in a bleomycin-induced pulmonary fibrosis rat model and the influence of FSAP on human pulmonary fibroblasts (HPF). The expression of FSAP was examined in a rat model of bleomycin-induced pulmonary fibrosis by immunohistochemical staining, quantitative real-time RT-PCR and Western blot analysis. The influence of FSAP on cell proliferation and migration of HPF was investigated by the BrdU incorporation assay and transwell cell culture chambers, respectively. The effect of FSAP on platelet-derived growth factor (PDGF)-stimulated p42/p44 mitogen-activated protein kinase (MAPK) activation on HPF was determined by Western blot analysis. FSAP was observed prominently in alveolar epithelial cells as well as microvascular endothelial cells of the lung parenchyma and was markedly increased at the early phase of bleomycin-induced pulmonary fibrosis, but decreased at the late stage, particularly during the pulmonary fibrosis. FSAP inhibited PDGF-stimulated proliferation, migration, p42/p44 MAPK phosphorylation and collagen III synthesis of the HPF. We concluded that epithelial cells in lungs represent a source of FSAP at the early stage in acutely injured lung. Moreover, we demonstrated an inhibitory effect of FSAP on PDGF-stimulated proliferation and migration of HPF in vitro, suggesting that FSAP may modulate inflammation and exert a beneficial effect on ARDS.

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Active transforming growth factor-β1 activates the procollagen I promoter in patients with acute lung injury

Abstract: Bronchoalveolar lavage fluid from ALI/ARDS patients activates procollagen I promoter, which is due partly to TGF-beta1. Activated TGF-beta1 may impact ARDS outcome independent of its effect on procollagen I activation.

Cited by 67 publications

References 46 publications

The relative balance of GM-CSF and TGF-β1 regulates lung epithelial barrier function

The relative balance of GM-CSF and TGF-β1 regulates lung epithelial barrier function

Detection of Fibroproliferation by Chest High-Resolution CT Scan in Resolving ARDS

Changes in factor VII-activating protease in a bleomycin-induced lung injury rat model and its influence on human pulmonary fibroblasts in vitro

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