The skyhook control technology is widely used in active vibration isolation and has proven effective. However, the absolute speed sensor used in the skyhook control technology is easily affected by external factors and may be easily damaged. There are few application scenarios for the skyhook control technology. To overcome this limitation, a brand-new approach is proposed for the design of an isolator that involves a voice coil motor (VCM) and an accelerometer. First of all, the proposed structure is introduced, and the dynamic model is established to achieve an analytical solution. Then, an integral acceleration feedback (IAF) algorithm is introduced and simulations are carried out. Finally, a prototype is constructed to verify its vibration isolation performance. From the experimental results, it can be concluded that the proposed active vibration control system (AVCS) can effectively reduce the peak value near the natural frequency, with a peak value reduction of 14.77 dB. Compared with the simulation results, the peak change rate at 12.5 Hz is 3.92%. AVCS with IAF can be applied to more application scenarios with a similar isolation effect to skyhook control technology.