The dynamic models of an integrated system based on active steering and an active suspension are established; these include a vehicle model, an active steering system model, an active suspension system model, a tyre model and a road input model. The performance evaluation indices of the integrated system are proposed, including the steering road feel, the steering sensitivity and the ride comfort. On the basis of the target cascading theory, an analytical target cascading method is researched. Considering the coupling factors of the integrated system, the optimization model of the integrated system is established with the target cascading method. Then, the parameters are optimized based on a multi-island genetic algorithm, and the optimized results are compared with those of the collaborative optimization method. Thus, a theoretical foundation and technical support for the integration design of the automotive chassis can be provided.