Active Vitamin D and Survival

Wolf, Myles

doi:10.1681/asn.2008060595

Cited by 9 publications

(14 citation statements)

References 13 publications

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“…Reduced levels of vitamin D (both inactive and active metabolites) has been proposed as a modifiable risk factor to reduce the burden of CVD in people with CKD 6 . The vitamin D receptor is found in the heart, vascular wall and the kidney and its activation regulates several genes apart from those involved in calcium and phosphate metabolism 5 . Vitamin D deficiency is also implicated in vascular dysfunction, and in vitro and animal data demonstrate that treatment with vitamin D analogues, such as calcitriol, can reduce arterial stiffness by multiple direct and indirect mechanisms including inhibition of mineralisation in vascular smooth muscle cells, anti‐inflammatory and antioxidative effects 5,6 …”

Section: Discussionmentioning

confidence: 99%

Effect of calcitriol treatment on arterial stiffness in people with type 2 diabetes and stage 3 chronic kidney disease

Karalliedde

Fountoulakis

Corcillo

et al. 2022

Brit J Clinical Pharma

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Section: Discussionmentioning

confidence: 99%

Effect of calcitriol treatment on arterial stiffness in people with type 2 diabetes and stage 3 chronic kidney disease

Karalliedde

Fountoulakis

Corcillo

et al. 2022

Brit J Clinical Pharma

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“…Properly designed randomized studies in the future could clarify cause-and-effect relationships of low vitamin D with health problems such as muscle weakness, cancer, autoimmune disease, diabetes, schizophrenia, depression, premenstrual syndrome, lung dysfunction, kidney disease, preeclamptic toxaemia, and cardiovascular disease. Data also suggest that adequate vitamin D prolongs lifespan (142,143), especially in patients with chronic renal disease (CKD) (144)(145)(146). The IOM report suggests an increase of mortality in those with serum vitamin D levels above 50 ng/mL, but this conclusion was based on a handful of observational reports.…”

Section: Extra Skeletal Effects Of Vitamin Dmentioning

confidence: 99%

Vitamin D: what clinicians need to know

Wimalawansa

2012

Sri Lanka J. Diabetes Endocrinol. Metab.

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Recent literature on vitamin D is full of controversies regarding its measurement, benefits, diagnosis, and management of its deficiency. In addition to addressing the consequences of deficiency, benefits of its replenishment, and clinical recommendations for supplements, this review addresses extra-skeletal effects of vitamin D. Vitamin D is essential for skeletal health and prevention of falls and injuries. Vitamin D enhances intestinal calcium absorption and mineralization of osteoid tissues. Rickets in children and osteomalacia in adults are classic manifestations of severe vitamin D deficiency. Cohort studies suggest that low 25 hydroxyvitamin D [25(OH)D] affects numerous and diverse physiologic functions, such as control of cell growth including cancer cells, protection against autoimmune disorders, and muscular coordination. Emerging data also suggest that low vitamin D levels may worsen disorders, including cancer, metabolic syndrome, obesity and diabetes, infectious diseases, and autoimmune disorders. Whether increased incidences of these diseases are consequences of widespread vitamin D deficiency is to be determined. Moreover, many reported relationships between vitamin D deficiency and diseases are based on epidemiological observations. Measurement of serum 25(OH)D is the way to evaluate vitamin D status. Serum 25(OH)D levels below 20 ng/mL are considered deficient, whereas optimum levels are between 30 and 50 ng/mL. An additional 1,000 IU of vitamin D per day generally is sufficient for lighter-skinned individuals; elderly, obese, and dark-skinned individuals and other groups of patients may need an additional 2,000 IU or more per day to maintain physiologic serum 25(OH)D levels.

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“…Whether activated Vitamin D treatments should extend beyond the management of secondary hyperparathyroidism has also been explored. Recent retrospective studies have shown that the use of vitamin D is associated with improved all‐cause and CV mortality in CKD‐D and CKD‐ND patients independent of calcium, phosphorus and parathyroid hormone (103). Vitamin D use has also been associated with decreased concentrations of proinflammatory cytokines in patients with CHF and regression of cardiac hypertrophy in dialysis patients (104,105).…”

Section: Risk Factors and Pathophysiology Of Cvd In The Ckd Populationmentioning

confidence: 99%