Active Wound Coverings: Bioengineered Skin and Dermal Substitutes

Lı́mová, Markéta

doi:10.1016/j.suc.2010.08.004

Cited by 57 publications

(36 citation statements)

References 84 publications

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“…The use of these alternative products avoids the donor-site problem on the patient, and animal derived dressings are easier to acquire. These products may be better in certain circumstances compared with synthetic alternatives [26,27]. Hydrocolloids act by autolysis, rehydrating the wound and thereby promote debridement [5,26].…”

Section: Discussionmentioning

confidence: 99%

Animal derived products may conflict with religious patients’ beliefs

2013

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BackgroundImplants and drugs with animal and human derived content are widely used in medicine and surgery, but information regarding ingredients is rarely obtainable by health practitioners. A religious perspective concerning the use of animal and human derived drug ingredients has not thoroughly been investigated. The purpose of this study was to clarify which parts of the medical and surgical treatments offered in western world-hospitals that conflicts with believers of major religions.MethodsReligious and spiritual leaders of the six largest religions worldwide (18 branches) were contacted. A standardised questionnaire was sent out regarding their position on the use of human and animal derived products in medical and surgical treatments.ResultsOf the 18 contacted religious branches, 10 replied representing the 6 largest religions worldwide. Hindus and Sikhs did not approve of the use of bovine or porcine derived products, and Muslims did not accept the use of porcine derived drugs, dressings or implants. Christians (including Jehovah’s Witnesses), Jews and Buddhists accepted the use of all animal and human derived products. However, all religions accepted the use of all these products in case of an emergency and only if alternatives were not available.ConclusionsThe views here suggest that religious codes conflict with some treatment regimens. It is crucial to obtain informed consent from patients for the use of drugs and implants with animal or human derived content. However, information on the origin of ingredients in drugs is not always available to health practitioners.

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Section: Discussionmentioning

confidence: 99%

Animal derived products may conflict with religious patients’ beliefs

2013

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“…Other skin substitutes like Permacol, Matriderm, and Oasis belong to the xenograft category [79,85]. Permacol is made of porcine dermis, whereas Matriderm ® is made of a matrix of bovine type I collagen with elastin (Figure 3e).…”

Section: Types Of Skin Substitutesmentioning

confidence: 99%

“…Permacol has a good aesthetic and functional outcome but is prone to infection, hematomas, and seromas [73,74], whereas, Matriderm involves a single stage procedure with increased vascularization and elasticity of regenerating tissue but lacks enough scientific evidence to verify its efficacy of a one-step procedure [103,110,111]. Another substitute is Oasis, which is derived from porcine intestinal submucosa [79,85]. …”

Section: Types Of Skin Substitutesmentioning

confidence: 99%

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Advances in Skin Regeneration Using Tissue Engineering

Vig

Chaudhari

Tripathi

et al. 2017

IJMS

533

418

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Tissue engineered skin substitutes for wound healing have evolved tremendously over the last couple of years. New advances have been made toward developing skin substitutes made up of artificial and natural materials. Engineered skin substitutes are developed from acellular materials or can be synthesized from autologous, allograft, xenogenic, or synthetic sources. Each of these engineered skin substitutes has their advantages and disadvantages. However, to this date, a complete functional skin substitute is not available, and research is continuing to develop a competent full thickness skin substitute product that can vascularize rapidly. There is also a need to redesign the currently available substitutes to make them user friendly, commercially affordable, and viable with longer shelf life. The present review focuses on providing an overview of advances in the field of tissue engineered skin substitute development, the availability of various types, and their application.

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“…The terms ‘dermal skin substitutes’ is commonly used to refer to a wide range of products that are currently available in the market. 6 In this article we will use the terms dermal skin substitutes, dermal substitutes, dermal matrices and dermal regeneration template interchangeably to refer to several types of skin substitutes that have been commonly reported in the soft tissue reconstructions of the upper extremity.…”

Section: Introductionmentioning

confidence: 99%