Active Wound Dressing With Artificial Capillaries for Temporary Wound Irrigation and Skin Cell Supply

Abstract

Medical treatment of burns and chronic wounds remains a challenge. We discussed a therapy concept that combines skin cell spray transplantation with a novel wound dressing based on artificial hollow fiber membrane capillaries. In skin cell-based therapy development, autologous skin progenitor cells are isolated from a healthy skin area and sprayed onto the wound. A medical device was introduced that uses perfused capillaries, known from clinical plasma separation, as a temporarily applied extracorporeal wound capillary bed. The functions of the dressing are comparable with those of dialysis; the capillaries, however, are applied externally onto the wound. Perfusion with a clinical peripheral nutrition and buffer solution can provide wound irrigation, wound debris removal, cell nutrition, pH regulation, and electrolyte balance while potentially serving to address delivery of regenerative factors and antibiosis. An innovative active skin wound dressing that provides cell support and stimulates regeneration by wound irrigation is discussed.

Collagenase-Labile Polyurethane Urea Synthesis and Processing into Hollow Fiber Membranes

“…Polymer Characterization. 1 HNMR spectra of the PUUs were recorded with a 300 MHz Bruker spectrometer using DMSO-d 6 as solvent. Intrinsic viscosities of PUUs at 25 °C were measured (n = 3) with HFIP as a solvent using an Ubbelohde viscometer.…”

Morphological and Functional Evidence of Sexual Dimorphism in the Retrochiasmatic Area Population of NK3R-containing Neurons in Sheep

“…These results are similar to previous findings that galanin expression throughout the hypothalamus, as a whole, is not sexually dimorphic in sheep (8,28). This is also in contrast to what is observed in rodents, as galanin expression is found to be highly sexually dimorphic in both mice (51) and rats (16). One report observed a slightly stronger intensity of galanin staining in male compared to female sheep and suggested that this neurons and the degree to which these populations participate in the LH surge remains unknown.…”

Artificial Organs 2012: A Year in Review

“…Jorn Plettig et al. of the Universitätsmedizin Berlin, Berlin, Germany described their therapy concept that combines skin cell spray transplantation with a novel wound dressing based on artificial hollow fiber membrane capillaries. Autologous skin progenitor cells are isolated from a healthy skin area and sprayed onto the wound.…”