The macroscopic characteristics of the fractured space and the microscopic pore features are critical factors determining the effectiveness of gangue slurry backfilling. To identify the key areas for slurry backfilling, a combination of theoretical analysis, simulation experiments, and on-site industrial trials was used to reveal the movement laws of backfilling space overlying the fractured zone. The distribution characteristics of voids available for slurry backfilling within the fractured space were explored, and the interaction between gangue slurry and goaf voids was clarified. A formula for calculating the void ratio in the caved zone was derived, and a model for the distribution of voids in the slurry backfilling space was established. This model identified the main areas where slurry backfilling should be focused, namely the overlapping space between the free accumulation zone and the load-influenced zone. Experimental results demonstrated that the porosity of the collapsed rock mass within the goaf follows a negative logarithmic function along both the dip and strike directions, which was consistent with the theoretical calculations. Through in-situ grouting backfilling experiments on the ground, the feasibility of gangue slurry backfilling in the goaf was verified, and the process of interaction between gangue slurry and goaf voids was elaborated. This process generally involves three stages: initial flow, vertical upwelling, and horizontal diffusion, all of which are closely interconnected. Practical engineering applications of gangue slurry backfilling were carried out in the free accumulation zone and the load-influenced zone at the Huangling No.2 coal mine. The successful validation of underground gangue slurry backfilling technology demonstrated its feasibility and the correctness of the theoretical approach. This research provides new evidence for environmentally friendly disposal of gangue materials.