Actividad analgésica del extracto acuoso liofilizado de las hojas de Bixa orellana L. en ratones albinos

Abstract

Se realizó un estudio experimental con el objetivo de evaluar el efecto analgésico del extracto acuoso liofilizado de las hojas de Bixa orellana L, a dosis de 100 y 150 mgkg-l administrado por vía oraL Para el desarrollo del mismo se utilizaron los Métodos de "Hot-plate" y "Contorsiones abdominales". Los animales seleccionados fueron ratones albinos machos de la cepa Balb/C53, con un peso corporal comprendido entre 23.67+ l.03g. Se utilizaron como controles positivos paracetamol e indometacina a dosis de 400 mgkg-l y 10 mgKg-l, respectivamente. Bixa orellana L. presenta actividad analgésica a nivel periférico, en el modelo de contorsiones abdominales, directamente proporcional a la dosis, bajo las condiciones experimentales.

A review of <i>Bixa orellana</i> L. (Annatto) leaves as medicinal resource: Use in the population as complementary medicine, phytotherapeutic action and quality parameters

“…The methanolic extract (500 mg/kg) was able to reduce the onset time and duration of sleep induced by pentobarbitone in Swiss mice, in addition to causing a neurodepressant effect by reducing the amount of movements and convulsions induced by strychnine, and also presenting an analgesic effect by decreasing the number of abdominal contractions induced by acetic acid (Shilpi et al, 2006). Analgesic activity was also observed for the aqueous extract (150 mg/kg), increasing the time spent on the "hot plate" and reducing the number of abdominal writhings (Betancourt et al, 2006). In turn, the nociceptive effect of the methanolic extract was described by Aktary et al (2020), so that the response time of the group treated with 200 mg/kg of the extract was 5.7 seconds (Aktary et al, 2020).…”

“…According to the diversity of the chemical constituents mentioned above, mainly in relation to the presence of bixin, flavonoids and terpenoids, pharmacological studies of the use of B. orellana leaves have also shown a wide variety of activities (Table 1) such as: antibacterial, antioxidant, neuroderpessant (Shilpi et al, 2006), antifungal (Singh & Vidyasagar, 2017), antileishmanial (Almeida et al, 2012), anti-venom (Otero et al, 2000), antidiarrheal (M.A. Tagne et al, 2019), analgesic (Betancourt et al, 2006), antiinflammatory (Moraes-Neto et al, 2022), antiulcer (Huamán et al, 2009), hepatoprotective (Huamán et al, 2013), healing (Milagros & Nieves, 2019), antihistamine (Yong et al, 2013), diuretic (Rahmatullah et al, 2009) and for the treatment of prostatitis (Cisneros-Hilario et al, 2014).…”