Actividad en suero de CK y CK-MB en pacientes con infección por el virus dengue

Agudelo-Salas, Ivony Y.; Quinceno, Nini; Duque, Juliana; Bosch, Irene; Restrepo, Berta Nelly

doi:10.15446/rsap.v19n4.39597

Cited by 4 publications

(1 citation statement)

References 20 publications

(26 reference statements)

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“…The first case of sinus node dysfunction related to dengue infection was reported in a threeyear-old boy who developed hypotension and bradycardia after recovering from dengue hemorrhagic fever [25]. Agudelo-Salas et al reported that in patients without a myocarditis diagnosis, a significant presence of symptoms may suggest its presence, including tachycardia (23.1%), bradycardia (15.4%), and hypotension (12.8%) [26]. As previously stated, the cardiac effects of dengue virus extend beyond myocarditis, and can affect the conduction system, including nonspecific ST-segment alterations and low QRS complex voltage, in addition to the arrhythmias previously described.…”

Section: Cardiac Manifestationsmentioning

confidence: 99%

Dengue Myocarditis: A Case Report and Major Review

Cristodulo,

Luoma-Overstreet,

Leite

et al. 2023

Global Heart

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Dengue is a viral disease transmitted by the bite of a female arthropod, prevalent primarily in tropical and subtropical regions. Its manifestations include asymptomatic infections, dengue fever, and a severe form called hemorrhagic dengue or dengue shock syndrome. Atypical manifestations can also occur, called expanded dengue syndrome.We describe the case of a 43-year-old man with an unusual presentation of dengue, demonstrating a workup suggestive of myocardial and pericardial damage. Symptoms and markers indicative of cardiac compromise improved after five days on antiinflammatory treatment.2 Cristodulo et al.

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Section: Cardiac Manifestationsmentioning

confidence: 99%

Dengue Myocarditis: A Case Report and Major Review

Cristodulo,

Luoma-Overstreet,

Leite

et al. 2023

Global Heart

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Creatine kinase-(MB) and hepcidin as candidate biomarkers for early diagnosis of pulmonary tuberculosis: a proof-of-concept study in Lambaréné, Gabon

et al. 2022

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Background The present study aimed to evaluate the diagnostic utility of creatine kinase-MB (CK-MB), hepcidin (HEPC), phospholipase A2 group IIA (PLa2G2A), and myosin-binding protein C (MYBPC1) for tuberculosis (TB). These four biomarkers are differentially regulated between quiescent Mycobacterium tuberculosis (Mtb) infected individuals (non-progressors to TB disease) and Mtb-infected TB disease progressors 6 months before the onset of symptoms. Methods We enrolled samples from patients experiencing moderate-to-severe pulmonary infections diseases including 23 TB cases confirmed by smear microscopy and culture, and 34 TB-negative cases. For each participant, the serum levels of the four biomarkers were measured using ELISA. Results The levels of CK-MB and HEPC were significantly reduced in patients with active TB disease. CK-MB median level was 2045 pg/ml (1455–4000 pg/ml) in active TB cases and 3245 pg/ml (1645–4000 pg/ml) in non-TB pulmonary diseases. Using the receiver operating characteristic curve (ROC) analysis, HEPC and CK-MB had the Area Under the Curve (AUC) of 79% (95% CI 67–91%) and 81% (95% CI 69–93%), respectively. Both markers correlated with TB diagnosis as a single marker. PLa2G2A and MYBPC1 with AUCs of 48% (95% CI 36–65%) and 62% (95% CI 48–76%) did not performed well as single biomarkers. The three markers’model (CK-MB-HEPC-PLa2G2A) had the highest diagnostic accuracy at 82% (95% CI 56–82%) after cross-validation. Conclusion CK-MB and HEPC levels were statistically different between confirmed TB cases and non-TB cases. This study yields promising results for the rapid diagnosis of TB disease using a single marker or three biomarkers model.

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Insights Into the Emerging Role of Myocarditis in Dengue Fever

Gupta

Gaba

et al. 2021

Curr Trop Med Rep

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Actividad en suero de CK y CK-MB en pacientes con infección por el virus dengue

Cited by 4 publications

References 20 publications

Dengue Myocarditis: A Case Report and Major Review

Dengue Myocarditis: A Case Report and Major Review

Creatine kinase-(MB) and hepcidin as candidate biomarkers for early diagnosis of pulmonary tuberculosis: a proof-of-concept study in Lambaréné, Gabon

Insights Into the Emerging Role of Myocarditis in Dengue Fever

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