Activin A regulates activities of peripheral blood natural killer cells of mouse in an autocrine and paracrine manner

Ma, Chunhui; Liu, Zhonghui; Shang, Shumi; Jiang, Lingling; Lv, Xinran; Qi, Yan; Cui, Xueling; Ge, Jingyan

doi:10.1016/j.yexcr.2018.11.013

Cited by 13 publications

(11 citation statements)

References 36 publications

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“…Previous studies have reported that activin A elicits an anti-inflammatory role in regulating the activation of various immune cells 46,47 . In the present study, it was further revealed that activin A inhibited TNF-α-mediated inflammation in fibroblasts, which confirmed the critical role of activin A in inflammation regulation.…”

Section: Discussionmentioning

confidence: 99%

Antagonistic effects of activin A and TNF-α on the activation of L929 fibroblast cells via Smad3-independent signaling

Jiang

Liu

et al. 2020

Sci Rep

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Fibroblasts play an important role in inflammation and tissue fibrosis. Both activin A and TNF-α can activate immune cells, however, the roles and relationship of them in activating fibroblasts in inflammation remain unclear. Here, this study revealed that TNF-α promoted the release of NO and IL-6 by L929 fibroblast cells, but co-treatment with activin A attenuated these effects. In contrast, activin A induced cell migration and increased the production of tissue fibrosis-related TGF-β1 and fibronectin, while TNF-α inhibited these function changes of L929 cells induced by activin A. Moreover, this study revealed that activin A and TNF-α regulated the activities of L929 cells via ERK1/2/MAPK pathway, rather than Smad3-dependent signaling pathway. Taken together, these data indicate that activin A and TNF-α exert mutually antagonistic effects on regulating fibroblasts activities, and the balance between their action may determine the process and outcome of fibroblasts-mediated inflammation.

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Section: Discussionmentioning

confidence: 99%

Antagonistic effects of activin A and TNF-α on the activation of L929 fibroblast cells via Smad3-independent signaling

Jiang

Liu

et al. 2020

Sci Rep

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“…( 44 ). Moreover, IL-10 expression in NK cells was not altered after activin A administration, while IL-2 expression was up-regulated ( 24 , 48 ).…”

Section: Activin a Regulation Of The Innate Immune Systemmentioning

confidence: 93%

“…In general, innate immune cells including macrophages, dendritic cells (DCs) and natural killer (NK) cells are the sources of activin A ( 12 , 22 – 24 ). Here, we describe the relationship between activin A and these cells, and make some comparison with those of TGF-β.…”

Section: Activin a Regulation Of The Innate Immune Systemmentioning

confidence: 99%

“…NK cells play roles as both activin A donors and activin A target cells in certain context. INHBA , ACVR2B , SMAD2/3/4 were all shown to be expressed in mouse peripheral blood NK cells ( 24 ). Stimulation of these cells with IL-2 in vitro could promote the release of activin A in a dose-dependent manner ( 24 ).…”

Section: Activin a Regulation Of The Innate Immune Systemmentioning

confidence: 99%

“…It was also pointed out that the lytic function of NK was not affected by activin A ( 44 ). Instead, activin A was considered to be an inhibitor of NK cell proliferation, as well as cytotoxicity by inhibiting the release of LDH with a decreased killing rate of YAC-1 cells ( 13 , 24 , 44 ).…”

Section: Activin a Regulation Of The Innate Immune Systemmentioning

confidence: 99%

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Different Immunoregulation Roles of Activin A Compared With TGF-β

Long

et al. 2022

Front. Immunol.

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Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-β, activin A also transmits signals through SMAD2/SMAD3, however, they bind to distinct receptors. Recent studies have uncovered that activin A plays a pivotal role in both innate and adaptive immune systems. Here we mainly focus its effects on activation, differentiation, proliferation and function of cells which are indispensable in the immune system and meanwhile make some comparisons with those of TGF-β.

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Activin A promoted the anti‐tumor effect of ActRIIA ^high CD8⁺ T cells in mouse hepatoma

Hu,

Zhao,

Zhang

et al. 2024

Cancer Medicine

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BackgroundActivin A, a noteworthy member of the TGF‐β superfamily. Activin A can regulate the biological functions of various immune cells, such as macrophages, neutrophils, NK cells, etc. The purpose of this study is to investigate the regulatory effect and related mechanisms of activin A on CD8+ T cells.MethodsThis study established a mouse subcutaneous transplantation model of hepatoma to explore whether activin A has a regulatory effect of CD8+ T cells. And reveal the biological characteristics of ActRIIA high CD8+ T cells.ResultsWe discovered that CD8+ T cells express ActRIIA, ActRIIB, and Smad2,3,4. Unlike high‐dose activin A, low‐dose activin A increased the content of CD8+ T cells while also suppressing tumor growth. In addition, low‐dose activin A promoted expression of perforin, granzyme B, CD69, CD11c, CD49b, Ki67 and ActRIIA in CD8+ T cells. And the results indicated that high‐dose activin A promotes the expression of PPM1A in T cells, while low‐dose activin A has no effect on these cells. The tumor contained more ActRIIA high CD8+ T cells compared to the peripheral blood and spleen. ActRIIA high CD8+ T cells highly express cytotoxic molecules and cytokines. And ActRIIA high CD8+ T cells not only expressed high levels of activation/co‐stimulatory markers CD69, CD278, and CD28, but also high levels of inhibitory markers CD366 and KLRG1. Different chemokine receptors displayed varying levels of expression in ActRIIA high CD8+ T cells. Additionally, these cells have a high proliferative potential. Finally, overexpression of Mettl3 inhibited the expression of ActRIIA in CD8+ T cells.ConclusionsThis study demonstrated that low‐dose activin A enhanced the anti‐tumor effect of CD8+ T cells, and ActRIIA high CD8+ T cells actively contribute to tumor immunity.

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Activin A regulates activities of peripheral blood natural killer cells of mouse in an autocrine and paracrine manner

Cited by 13 publications

References 36 publications

Antagonistic effects of activin A and TNF-α on the activation of L929 fibroblast cells via Smad3-independent signaling

Antagonistic effects of activin A and TNF-α on the activation of L929 fibroblast cells via Smad3-independent signaling

Different Immunoregulation Roles of Activin A Compared With TGF-β

Activin A promoted the anti‐tumor effect of ActRIIA ^high CD8⁺ T cells in mouse hepatoma

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Activin A regulates activities of peripheral blood natural killer cells of mouse in an autocrine and paracrine manner

Cited by 13 publications

References 36 publications

Antagonistic effects of activin A and TNF-α on the activation of L929 fibroblast cells via Smad3-independent signaling

Antagonistic effects of activin A and TNF-α on the activation of L929 fibroblast cells via Smad3-independent signaling

Different Immunoregulation Roles of Activin A Compared With TGF-β

Activin A promoted the anti‐tumor effect of ActRIIA high CD8+ T cells in mouse hepatoma

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Activin A promoted the anti‐tumor effect of ActRIIA ^high CD8⁺ T cells in mouse hepatoma