2004
DOI: 10.1677/joe.0.1820055
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Activin and inhibin receptor gene expression in the ewe pituitary throughout the oestrous cycle

Abstract: In mammals, activin and inhibin are important regulators of FSH secretion. Previous studies have demonstrated that primary ovine pituitary cells express different activin receptor subtypes: activin receptor-like (ALK)2, ALK4, activin type II receptor A (ActRIIA), ActRIIB and Smad proteins in vitro. Here, we have carried out physiological studies to investigate the pattern of mRNA expression of the activin receptor subunits in the ewe pituitary throughout the oestrous cycle. The oestrous cycles of ewes were syn… Show more

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Cited by 11 publications
(14 citation statements)
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“…Chronic treatment of pituitary cells with GnRH for 6 h, mimicking a situation similar to the preovulatory surge, induced a decrease in the level of FSHb mRNA. This is consistent with the reduction observed in vivo in pituitaries collected during the LH surge (Fafioffe et al 2004). Moreover, this agrees with reports showing that chronic GnRH inhibits the activity of the oFSHb promoter and the rat FSHb expression in vivo and in vitro (Attardi et al 1989, Lerrant et al 1995, Shafiee-Kermani et al 2007).…”
Section: Discussionsupporting
confidence: 92%
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“…Chronic treatment of pituitary cells with GnRH for 6 h, mimicking a situation similar to the preovulatory surge, induced a decrease in the level of FSHb mRNA. This is consistent with the reduction observed in vivo in pituitaries collected during the LH surge (Fafioffe et al 2004). Moreover, this agrees with reports showing that chronic GnRH inhibits the activity of the oFSHb promoter and the rat FSHb expression in vivo and in vitro (Attardi et al 1989, Lerrant et al 1995, Shafiee-Kermani et al 2007).…”
Section: Discussionsupporting
confidence: 92%
“…However, BMPR2 is present on the gonadotrope cells. Moreover, the level of ActR2A mRNA is similar throughout the estrous cycle (Fafioffe et al 2004). All together, these data led us to study preferentially BMPR2, BMPR1A, and BMPR1B.…”
Section: Discussionmentioning
confidence: 79%
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