Activity and determinants of cholinesterases and paraoxonase-1 in blood of workers exposed to non-cholinesterase inhibiting pesticides

Lozano-Paniagua, David; Gómez-Martín, Antonio; Gil, Fernando; Parrón, Tesifón; Alarcón, Raquel; Requena, Mar; Lacasaña, Marina; Hernández, Antonio F.

doi:10.1016/j.cbi.2016.04.008

Cited by 21 publications

(10 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This paradoxical effect was attributed to enhanced BuChE synthesis as a natural protective mechanism against sub-toxic pesticide exposure. 12 In this study, lower birth weight and gestational age can be seen in newborns with congenital anomalies along with a decrease in serum cholinesterase levels (Table 1). A study by Farahat et al reported that similar findings in case of organophosphorus exposure.…”

Section: Discussionsupporting

confidence: 49%

Evaluation of serum paraoxonase, 1 and its association with serum cholinesterase as a cause of congenital anomalies

Ghosh

Bhardwaj

Singh

et al. 2020

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Birth defects are conditions of prenatal origin that are present at birth, potentially impacting an infant's health, development, and/or survival. Several environmental toxins affect the growth of the fetus during the intrauterine period by affecting various cellular components. Pesticides and industrial chemicals are known toxins that can hinder the developmental process. In this study, authors are evaluating the relation of cholinesterase and paraoxonase-1 with visible congenital anomalies.Methods: Sixty babies delivered in the labor room were selected for the study. They were divided into two groups. Thirty newborns with visible congenital anomalies were included in Group I. Only babies with visible congenital anomalies were taken as inclusion criteria for this group. This group was compared with Group II, which were taken as controls and consisted of 30 healthy newborns without any congenital anomalies. Serum cholinesterase and serum paraoxonase-1 were estimated and statistical tests were applied.Results: Serum cholinesterase and serum paraoxonase-1 were significantly low in the babies with visible congenital anomalies. Serum cholinesterase levels showed a statistically significant positive correlation with serum paraoxonase 1 level in both the groups.Conclusions: Decrease in acetylcholinesterase by various environmental toxins and the associated decrease in serum paraoxonase level imposes significant oxidant stress and the resultant risk of developing congenital anomalies.

show abstract

Section: Discussionsupporting

confidence: 49%

Evaluation of serum paraoxonase, 1 and its association with serum cholinesterase as a cause of congenital anomalies

Ghosh

Bhardwaj

Singh

et al. 2020

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…Many studies had shown significantly lower cholinesterase levels in pesticide users compared with non-pesticide users [11,12,13]. A new study found that the reduction of cholinesterase was not only caused by organophosphate or carbamate [14]. Farmers who used pesticides other than organophosphate or carbamate also had lower cholinesterase levels compared with the unexposed group [15].…”

Section: Discussionmentioning

confidence: 99%

The Association between Pesticide Exposure and Neurological Signs and Symptoms in Farmers in Magelang District, Central Java, Indonesia

Setyopranoto

Argo

Ramadhani

et al. 2020

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Excessive use of pesticides is known to cause neurotoxicity. Chronic effects of pesticide poisoning include neuropathy and tremors. AIM: This study aimed to determine the association between pesticide exposure and the occurrence of neurological signs and symptoms, especially neuropathy and tremor, in farmers. METHODS: This was a cross-sectional study. The study location was Seloprojo Village, Ngablak District, Magelang Regency, Central Java Province. Farmers as subjects were recruited to determine neuropathy using Diabetic Neuropathy Symptom (DNS) and Diabetic Neuropathy Examination (DNE) scoring. Tremor events were measured with Tremor Rating Scale (TRS). Cholinesterase levels were examined using venous blood samples to determine the level of pesticide poisoning. RESULTS: Of the 120 farmers studied, 68.3% experienced pesticide poisoning with cholinesterase levels below normal values. Weakness of the upper limb was found in 10 subjects (8.33%), while weakness of the lower limbs was found in 6 subjects (5%). There were 59.2% farmers who met the neuropathy criteria from the DNS score and those who met the neuropathic criteria from the DNE score were 6.7%. Tremor symptoms were found in 71.7% of the farmers. There was no significant association between cholinesterase levels and DNS score (p = 0.737), but there were significantly lower levels of cholinesterase (p = 0.046) in the neuropathy group measured with DNE score. There was no significant association between cholinesterase levels and TRS (p = 0.204). CONCLUSION: Cholinesterase levels were significantly associated with neuropathy incidence measured with DNE criteria but statistically not related to tremors in farmers exposed to pesticides.

show abstract

“…Also, these individuals showed enhanced serum PON1activity. It is hypothesized that an up-regulation of these enzymes could occur as an adaptive response to compensate for the adverse effects of pesticide exposure [ 50 ]. Interestingly, such up-regulation, along with AChE inhibition, have both been observed in populations exposed to non-organophosphates pesticides like pyrethroids or neonicotinoids, among others.…”

Section: Discussionmentioning

confidence: 99%

Biomonitoring of blood cholinesterases and acylpeptide hydrolase activities in rural inhabitants exposed to pesticides in the Coquimbo Region of Chile

et al. 2018

View full text Add to dashboard Cite

In Chile, agriculture is a relevant economic activity and is concomitant with the use of pesticides to improve the yields. Acute intoxications of agricultural workers occur with some frequency and they must be reported to the surveillance system of the Ministry of Health. However the impacts of chronic and environmental pesticide exposure have been less studied. Among pesticides frequently used in Chile for insects control are organophosphates (OP) and carbamates (CB). They are inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). In this study we determined the pattern of both biomarkers activity in three populations with different type of chronic exposure to OP/CB: environmentally exposed (EE), occupationally exposed (OE) and a reference group (RG) without exposure. Besides this, we also measured the activity of acylpeptide hydrolase (APEH), an enzyme involved in relevant functions in the central synapses that is also expressed in erythrocytes and previously reported to be highly inhibited by some OP. A baseline measurement was done in both exposure groups and then a second measurement was done during the spraying season. The RG was measured only once at any time of the year. Our results indicate that people under chronic OP/CB exposure showed an adaptive response through an increase of basal BChE activity. During the spray season only BChE activity was decreased in the EE and OE groups (p<0.05 and p<0.01, respectively) and the higher magnitude of BChE inhibition was observed in the EE group. The analysis of the frequencies of inhibition above 30% (biological tolerance limit declared by Chilean legislation) indicated that BChE was most frequently inhibited in the EE group (53% of the individuals displayed inhibition) and AChE in the OE group (55% of the individuals displayed AChE inhibition). APEH activity showed the highest frequency of inhibition in the EE group independent of its magnitude (64%). Our results demonstrate that the rural population living nearby agricultural settings displays high levels of environmental exposure. APEH activity seems to be a sensitive biomarker for acute low-level exposure and its usefulness as a routine biomarker must to be explored in future studies. Systematic biomonitoring and health outcomes studies are necessary as well as obtaining the baseline for BChE and AChE activity levels with the aim to improve environmental and occupational health policies in Chile.

show abstract

Activity and determinants of cholinesterases and paraoxonase-1 in blood of workers exposed to non-cholinesterase inhibiting pesticides

Cited by 21 publications

References 43 publications

Evaluation of serum paraoxonase, 1 and its association with serum cholinesterase as a cause of congenital anomalies

Evaluation of serum paraoxonase, 1 and its association with serum cholinesterase as a cause of congenital anomalies

The Association between Pesticide Exposure and Neurological Signs and Symptoms in Farmers in Magelang District, Central Java, Indonesia

Biomonitoring of blood cholinesterases and acylpeptide hydrolase activities in rural inhabitants exposed to pesticides in the Coquimbo Region of Chile

Contact Info

Product

Resources

About