Activity and Distribution of Superoxide Dismutase in the Layers of Polyester Grafts

Abstract

The aim of the present study was to evaluate superoxide dismutase (CuZn-SOD) activity in the principal layers of polyester grafts implanted into the abdominal aorta of dogs. The grafts were examined 7 days and 1, 4 and 12 months after the operation. It was found that SOD activity occurred in all polyester graft layers during the whole experiment. The neoin-tima activity was 1.5-fold lower during the 1 st month; with the passage of time, it became 2-fold lower than in the normal aorta (p < 0.01). SOD activity in the medial and outer graft layers behaved similarly: it was lowest after 7 days, increased after 1 month and significantly decreased after 4 and 12 months (p < 0.01). Our study shows that the activity of SOD is low in polyester grafts and it can thus be inferred that protection against the superoxide anion is inadequate.

Modification of inflammatory response to implanted biomedical materialsin vivo by surface bound superoxide dismutase mimics

“…6 SOD activity in tissues surrounding implant devices is diminished and is inadequate to regulate the redox state in the implant bed. 40 Therapeutic success with systemically applied SOD has been efficacious in treating pathologies related to biomedical devices including acute inflammation in ischemia/ reperfusion injury and transplantation rejection and post-radiation fibrosis. Finally, SOD gene therapy studies in vitro 41 and in vivo 42 have reported that elevated SOD reduces NF-B and AP-1 activation in the course of ameliorating ischemia reperfusion injury and acute transplant rejection.…”