2009
DOI: 10.1158/0008-5472.sabcs-4115
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Activity and safety of sunitinib in combination with trastuzumab for the treatment of metastatic breast cancer: initial results from a phase II study.

Abstract: #4115 Background: Sunitinib (SU) is an oral, multitargeted tyrosine kinase inhibitor of VEGFRs, PDGFRs, KIT, RET, FLT3, and CSF-1R, with proven single-agent activity in pts with advanced BC. Trastuzumab (T) is indicated as both monotherapy for second-line treatment and in combination with taxane-based therapies for first-line treatment of metastatic BC. This study investigates the activity and safety/tolerability of SU administered in combination with T in pts with advanced, HER2+ BC.&#x2028… Show more

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Cited by 5 publications
(3 citation statements)
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“…The most common adverse events were diarrhea, asthenia, and hypertension. There was one death due to cardiogenic shock [15 ]. An exploratory study with 22 patients evaluated sunitinib and docetaxel for advanced breast cancer after anthracycline-based adjuvant chemotherapy.…”
Section: Sunitinibmentioning
confidence: 99%
“…The most common adverse events were diarrhea, asthenia, and hypertension. There was one death due to cardiogenic shock [15 ]. An exploratory study with 22 patients evaluated sunitinib and docetaxel for advanced breast cancer after anthracycline-based adjuvant chemotherapy.…”
Section: Sunitinibmentioning
confidence: 99%
“…Therefore novel treatment combinations are being evaluated. For example, early data have been obtained from a single‐arm, Phase Ib study of sunitinib plus docetaxel plus trastuzumab, and a Phase II study of sunitinib plus trastuzumab in HER2+ patients with metastatic breast cancer 54, 55. In addition, a Phase III trial of trastuzumab plus docetaxel with or without bevacizumab as first‐line treatment for metastatic breast cancer is ongoing and due to complete in 2011.…”
Section: Blood Vessel Morphologymentioning
confidence: 99%
“…In einer Phase-II-Studie bei Frauen mit HER2-überexprimierendem, Trastuzumabnaivem Mammakarzinom, konnte durch eine Kombination von Sunitinib mit Trastuzumab und Docetaxel in der Erstlinientherapie ein objektives Ansprechen von beinahe 78 % erzielt werden. Die Ansprechrate der Sunitinib-Kombination liegt damit deutlich über jener, die üblicherweise in diesem Setting durch die Gabe von Trastuzmab und Docetaxel erreicht werden kann[17].Es besteht kein Interessenskonflikt. [1] Yarden Y, Sliwkowsky MX.…”
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