Activity-based costing evaluation of [18F]-fludeoxyglucose production

Krug, Bruno; Zanten, A. van; Pirson, Anne-Sophie; Crott, Ralph

doi:10.1007/s00259-007-0551-x

Cited by 15 publications

(13 citation statements)

References 18 publications

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“…Most of the known probes (such as 18 F-FDG (9,10) and 3′-deoxy-3′- 18 F-fluorothymidine (11)) involve 2 synthetic steps that are precluded by radioisotope concentration and followed by purification and formulation of the injectable dose. Others (e.g., 2′-deoxy-2′- 18 F-fluoro-5-methyl-1-β-D-arabinofuranosyluracil (12) or 18 F-fluoroazomycin-arabinoside (13)) require longer synthetic procedures that may limit their clinical use.…”

mentioning

confidence: 99%

Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis

Elizarov¹,

Dam²,

Shin³

et al. 2010

J Nucl Med

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An integrated elastomeric microfluidic device, with a footprint the size of a postage stamp, has been designed and optimized for multistep radiosynthesis of PET tracers. Methods: The unique architecture of the device is centered around a 5-mL coin-shaped reactor, which yields reaction efficiency and speed from a combination of high reagent concentration, pressurized reactions, and rapid heat and mass transfer. Its novel features facilitate mixing, solvent exchange, and product collection. New mixing mechanisms assisted by vacuum, pressure, and chemical reactions are exploited. Results: The architecture of the reported reactor is the first that has allowed batch-mode microfluidic devices to produce radiopharmaceuticals of sufficient quality and quantity to be validated by in vivo imaging. Conclusion: The reactor has the potential to produce multiple human doses of 18 F-FDG; the most impact, however, is expected in the synthesis of PET radiopharmaceuticals that can be made only with low yields by currently available equipment.

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mentioning

confidence: 99%

Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis

Elizarov¹,

Dam²,

Shin³

et al. 2010

J Nucl Med

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“…They concluded that in traditional method the cost of non-profit deposits is less than civil participation and credit sales while civil participation and credit sales have been equal in cost and also using activity-based costing helps to calculate the exact costs of each one of the activities (studying, approving, paying, supervising and liquidating activities) which help the improvement of organizational activities' efficiency. Krug et al (2008) presented a paper entitled: "Activitybased costing evaluation of [18F]-Fludeoxy Glucose production", and assessed the production of (F-FDG), using Positron Emission Tomography (PET) by using activity-based costing system. The cost of performing positron emission tomography service is extremely affected by the radio drug used and its price often varies from 300 to 500 Euros for each dose used for the patient.…”

Section: Literature Reviewmentioning

confidence: 99%

A comparative study of activity-based costing system and the traditional system: A case study of Refah Bank

Sarokolaei¹,

Ebrati²,

Khanghah³

et al. 2012

Afr. J. Bus. Manage.

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The goal of the present research is to study the activity-based costing system and the traditional system based on the volume comparatively in order to calculate the cost of the deposits in Refah Bank in Iran. Thus, first the deposit costs were calculated by using the volume based costing and then activity-based costing system was used to calculate the cost of deposits. In this research, the data from the whole branches of Refah Bank of Iran was used instead of focusing on the data gained from a limited number of branches. Also, regarding the existence of four different kinds of deposits, four different hypotheses were devised. Additionally, in an independent hypothesis, hypothesis 5, we studied the meaningfulness of the relationship between the ratio of staff's activities and the ratio of indirect costs of the deposits. The results show that there is not a meaningful difference between the cost calculated by activity-based costing and traditional method for current and saving deposits. But regarding the accounting calculations and the figure of cost ranking, there is a significant difference and activity-based costing system is absolutely more efficient than the traditional one. Also, the results of the research show that there is a meaningful difference between the cost calculated by activity-based costing and traditional system for long-term and other deposits. Also, the results of the research show that there is a meaningful relationship between the ratios of staff activities with overhead cost ratio for each of the deposits.

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“…The availability of commercial sources of 18 F-FDG and its purchase on a unit dose basis allows the operation of a PET imaging center without the prohibitive overhead costs of operating and maintaining a cyclotron [4][5][6]. As a result of the widespread availability of 18 F-FDG, many of the PET and PET/computed tomography (CT) imaging centers in existence today are single-camera facilities.…”

Section: Introductionmentioning

confidence: 99%

On the Significance of Defective Block Detectors in Clinical 18F-FDG PET/CT Imaging

et al. 2010

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Activity-based costing evaluation of [18F]-fludeoxyglucose production

Abstract: INTRODUCTION: As healthcare expenses are escalating in many countries, the sector faces a new challenge of becoming more cost efficient. There is an urgent need for more accurate data on the costs of healthcare procedures.

Cited by 15 publications

References 18 publications

Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis

Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis

A comparative study of activity-based costing system and the traditional system: A case study of Refah Bank

On the Significance of Defective Block Detectors in Clinical 18F-FDG PET/CT Imaging

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