Activity-Based Prospective Memory in Schizophrenia

Kumar, Deepak; Nizamie, S. Haque; Jahan, Masroor

doi:10.1080/13854040701396687

Cited by 24 publications

(15 citation statements)

References 27 publications

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“…Confirming our first hypothesis, FDRs performed significantly poorer on both TBPM and EBPM compared to HCs, and shared a similar pattern of PM performance with schizophrenia patients [9], [11], [12], [39] before and after controlling for potential confounding effects of basic demographic characteristics. This finding suggests that PM may be related to the genetic susceptibility for schizophrenia and that it could be considered as a potential endophenotype.…”

Section: Discussionsupporting

confidence: 80%

Prospective Memory Performance in Non-Psychotic First-Degree Relatives of Patients with Schizophrenia: A Controlled Study

et al. 2014

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ObjectiveWe aimed at investigating prospective memory and its socio-demographic and neurocognitive correlates in non-psychotic, first-degree relatives (FDRs) of patients with schizophrenia compared to patients with first episode schizophrenia (FES), and healthy controls (HCs).MethodsForty-seven FES patients, 50 non-psychotic FDRs (23 offspring and 27 siblings) of patients with chronic schizophrenia (unrelated to the FES group) and 51 HCs were studied. The Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT) was used to measure time-based prospective memory (TBPM) and event-based prospective memory (EBPM) performance. Other cognitive functions (involving respective memory and executive functions) were evaluated with standardized tests.ResultsAfter controlling for basic demographic characteristics including age, gender and educational level, there was a significant difference between FDRs, FES and HCs with respect to both TBPM (F(2,142) = 10.4, p<0.001) and EBPM (F(2,142) = 10.8, p<0.001). Multiple linear regression analyses revealed that lower scores of the Hopkins Verbal Learning Test-Revised (HVLT-R) and the STROOP Word-Color Test (SWCT) contributed to TBPM impairment, while lower educational level and higher scores of the Color Trails Test-2 (CTT-2) contributed to EBPM deficit in FDRs.ConclusionsFDRs share similar but attenuated prospective memory impairments with schizophrenia patients, suggesting that prospective memory deficits may represent an endophenotype of schizophrenia.

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Section: Discussionsupporting

confidence: 80%

Prospective Memory Performance in Non-Psychotic First-Degree Relatives of Patients with Schizophrenia: A Controlled Study

et al. 2014

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“…A study comparing the prospective memory of 42 healthy people with 42 people suffering with schizophrenia, showed a deficit in the group of patients with schizophrenia. This reinforces the hypothesis that there is a cognitive impairment in schizophrenia (Kumar et al 2008).…”

Section: Schizophrenia and Alzheimer's Diseasesupporting

confidence: 88%

Alzheimer´s Disease associated with Psychiatric Comorbidities

Garcez

Falchetti

Mina

et al. 2015

An. Acad. Bras. Ciênc.

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Alzheimer's disease (AD) is the most common cause of dementia and has become a severe public health issue. It is estimated that globally, 35.6% of people have some form of dementia. This number is expected to double by 2030, and possibly even triple by 2050. The disease is associated with deficits in cognition/ memory and a reduced ability in coping with everyday life. Moreover, patients can experience behavioral alterations such as mood swings, depression and hallucinations. Therefore, it is common to find the presence of neuropsychiatric comorbidities such as depression, schizophrenia and bipolar disorder during the course or development of AD. These disorders can become severe enough to interfere with the patients daily functioning, and can worsen the course of the disease. However, little is known about the causal relationship between psychiatric comorbidities and AD, or the reasons for the predisposition of some individuals to such disorders. Therefore, the purpose of this review is to clarify the causal relationship between depression, schizophrenia and bipolar disorder with AD.

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“…For instance, impairments in PM have been demonstrated in children and/or adolescents with neurodevelopmental disorders such as autism (Farrant, Boucher, & Blades, 1999; Jones et al, 2011), schizophrenia (Kumar, Nizamie, & Jahan, 2008), acquired traumatic brain injury (TBI, Kinsella et al, 1996; McCauley et al, 2010; Tay, Ang, Lau, Meyyappan, & Collinson, 2010), and those who use substances known to effect brain development (e.g., alcohol, Heffernan & O’Neil, 2012; cigarettes, Heffernan, O’Neill, & Moss, 2012; and cannabis, Bartholomew, Holroyd, & Heffernan, 2010). …”

Section: Pm In Special Populationsmentioning

confidence: 99%

Relations among prospective memory, cognitive abilities, and brain structure in adolescents who vary in prenatal drug exposure

Robey

Buckingham-Howes

Salmeron

et al. 2014

Journal of Experimental Child Psychology

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This investigation examined how prospective memory (PM) relates to cognitive abilities (i.e., executive function, attention, working memory, and retrospective memory), and brain structure in adolescents who vary in prenatal drug exposure (PDE). The sample included 105 (55 female, 50 male) urban, primarily African American adolescents (mean age 15.5 years) from low socioeconomic status (SES) families; 56% (n=59) were prenatally exposed to drugs (heroin and/or cocaine) and 44% (n=46) were not prenatally exposed, but similar in age, gender, race, and SES. Executive functioning, attentional control, working memory, retrospective memory, and overall cognitive ability were assessed by validated performance measures. Executive functioning was also measured by caregiver report. A subset of 52 adolescents completed MRI scans, which provided measures of subcortical gray matter volumes and thickness of prefrontal, parietal and temporal cortices. Results revealed no differences in PM performance by PDE status, even after adjusting for age and IQ. Executive function, retrospective memory, cortical thickness in frontal and parietal regions, and volume of subcortical regions (i.e., putamen and hippocampus) were related to PM performance in the sample overall, even after adjusting for age, IQ, and total gray matter volume. Findings suggest that variations in PM ability during adolescence are robustly related to individual differences in cognitive abilities, in particular executive function and retrospective memory, and brain structure, but do not vary by PDE status.

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Activity-Based Prospective Memory in Schizophrenia

Cited by 24 publications

References 27 publications

Prospective Memory Performance in Non-Psychotic First-Degree Relatives of Patients with Schizophrenia: A Controlled Study

Prospective Memory Performance in Non-Psychotic First-Degree Relatives of Patients with Schizophrenia: A Controlled Study

Alzheimer´s Disease associated with Psychiatric Comorbidities

Relations among prospective memory, cognitive abilities, and brain structure in adolescents who vary in prenatal drug exposure

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