Activity Behaviors and Physiological Characteristics of Women With Advanced-Stage Ovarian Cancer: A Preliminary Cross-sectional Investigation

Schofield, Christelle; Newton, Robert U.; Cohen, Paul A.; Galvão, Daniel A.; McVeigh, Joanne A.; Hart, Nicholas; Mohan, Ganendra Raj; Tan, Jason; Salfinger, Stuart; Straker, Leon; Peddle-McIntyre, Carolyn J.

doi:10.1097/igc.0000000000001197

Cited by 10 publications

(9 citation statements)

References 41 publications

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“…The importance of monitoring the physical and psychological side effects of treatment in cancer survivors is also emphasized in recent studies [ 13 – 15 ]. Although activity behaviors and physical function were compared in a preliminary study conducted with advanced OC survivors and controls [ 16 ], no studies comprehensively evaluated the effects of treatment and/or outcomes of disease processes in early and advanced OC survivors. Therefore, the primary aim of this study was to compare functional status (functional exercise capacity, functional fitness, and muscle endurance) and health-related parameters (peripheral, lower extremity and respiratory muscle strength, physical activity level, fatigue, neuropathy, level of depression and anxiety, and quality of life) of early stage (stage I or II) and advanced stage (III or IV) OC survivors and healthy controls.…”

Section: Introductionmentioning

confidence: 99%

The comparison of functional status and health-related parameters in ovarian cancer survivors with healthy controls

Gultekin,

Cakir,

Guc

et al. 2024

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Purpose The primary purpose of this study was to evaluate functional status and health-related parameters in ovarian cancer (OC) survivors and to compare these parameters with healthy controls. The secondary purpose of this study was to compare these parameters in early and advanced OC survivors. Methods Thirty-two OC survivors (n = 15 early stage; n = 17 advanced stage) with no evidence/suspicion of cancer recurrence after completing adjuvant local and systemic treatments for at least 12 months and 32 healthy controls were recruited for functional- and health-related assessments. Participants were assessed using the following methods of measuring the following: 6-min walk test (6MWT) for functional exercise capacity, 30-s chair stand test (30 s-CST) for functional fitness and muscle endurance, a handheld dynamometer for peripheral muscle strength, and a handheld dynamometer for lower extremity strength, Medical Micro RPM for respiratory muscle strength, International Physical Activity Questionnaire-Short Form (IPAQ-SF) for physical activity level, and Eastern Cooperative Oncology Group Performance Scale (ECOG-PS) for performance status, Checklist Individual Strength (CIS) for fatigue, Treatment/Gynecological Oncology-Neurotoxicity (FACT/GOG-NTX) for neuropathy, the Hospital Anxiety and Depression Scale (HADS) for anxiety and depression level, and the World Health Organization-Five Well-Being Index (WHO-5) for generic quality of life. Results All OC survivors underwent surgery and chemotherapy, and only 9.4% received radiotherapy in addition to chemotherapy. The median recurrence-free period post-completion of adjuvant treatments was 24.00 (12.00–75.00) months. OC survivors had lower 6MWT (m) (p < 0.001, r = 1.50), peripheral muscle strength (p = 0.005, r = 0.72), knee extension (p < 0.001, r = 1.54), and respiratory muscle strength (maximal inspiratory pressure) (p < 0.001, r = 1.90) (maximal expiratory pressure) (p < 0.001, r = 1.68) compared to healthy controls. HADS-A (p = 0.005, r = 0.75) and CIS scores (p = 0.025, r = 0.59) were also higher in the OC survivors. Early-stage OC survivors had better 6MWT (m) than advanced-stage OC survivors (p = 0.005, r = 1.83). Peripheral muscle strength was lower in advanced-stage OC survivors (p = 0.013, r = 0.92). FACT/GOG-NTX scores were higher in early-stage OC survivors (p < 0.001, r = 1.42). No significant differences were observed between early- and advanced-stage OC survivors in other measures (p < 0.05). Conclusion The findings suggest functional status, and health-related parameters are negatively affected in OC survivors. Additionally, higher levels of fatigue, neuropathy anxiety, and depression were reported in advanced OC survivors.

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Section: Introductionmentioning

confidence: 99%

The comparison of functional status and health-related parameters in ovarian cancer survivors with healthy controls

Gultekin,

Cakir,

Guc

et al. 2024

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“…In cancer care, physical activity is recommended as an adjunct cancer therapy, with emerging evidence supporting its efficacy in improving physical function and enhancing psychosocial health in women with ovarian cancer [ 14 , 15 ]. Despite the reported benefits of regular participation in physical activity in other cancer groups [ 12 ], recent evidence has found that most women with ovarian cancer are insufficiently physically active following diagnosis [ 15 – 17 ]. Current guidelines recommend all people diagnosed with cancer participate in 150 min of moderate-intensity aerobic activity and two resistance sessions per week [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Disease progression, aggressive treatments, and high rates of recurrence have all been identified to negatively impact physical activity participation in women with ovarian cancer [ 14 , 15 ]. Therefore, there is a clinical need to understand further why many women with ovarian cancer are physically inactive [ 15 , 17 ]. Furthermore, understanding enablers of physical activity participation in this patient group are equally as important to develop delivery models of physical activity that are in keeping with the needs and preferences of women living with ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Barriers and enablers to participation in physical activity among women diagnosed with ovarian cancer

2023

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Purpose Ovarian cancer is the leading cause of death among gynecological cancers, with low survival rates and a high disease burden. Despite the known benefits, most women reduce their participation in physical activity following diagnosis. Little is known about ovarian cancer survivors’ experiences of physical activity. The primary aim of this study was to explore the barriers and enablers to participation in physical activity among women diagnosed with ovarian cancer. Methods A qualitative descriptive study design was conducted via semi-structured interviews with nine women diagnosed with ovarian cancer (stages I–IV; 40–77 years). The interviews took place at the participant’s home via telephone or online video conferencing software Coviu©. An inductive thematic approach was used. The organization and coding of data were completed using NVivo computer software (Version 12.6.0, QSR International Pty Ltd.). Weekly discussions occurred among the research team to ensure that themes accurately represented participant views. The consolidated criteria for reporting qualitative studies (COREQ) 32-item checklist were followed. Results The main barriers to physical activity participation that emerged were (i) the lack of referral to an exercise professional within the multidisciplinary cancer team, (ii) fear of injury after surgery and during treatment, and (iii) treatment-related side effects. However, many of the participants perceived benefits of physical activity related to (i) enhanced physical and psychological health, (ii) improved cancer outcomes, and (iii) social benefits as key enablers of physical activity participation. Conclusions Physical activity interventions for women with ovarian cancer should address the modifiable barriers identified in this study. A key focus should be to streamline timely referral pathways within the multidisciplinary team, including exercise professionals, dietitians, psychologists, and specialists nurses following a diagnosis of ovarian cancer. Further research and service development are needed to optimize supported self-management through (i) education about the importance of physical activity to both healthcare professionals and women alike, (ii) enhanced symptom management for women, which was identified as a barrier to participation, and (iii) the development of shared care plans and patient center goals to address any fears or concerns. Implications for cancer survivors People diagnosed with ovarian cancer have low participation levels of physical activity. Cancer care professionals’ support could increase physical activity uptake and reduce some of the burden of an ovarian cancer diagnosis.

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“…In OC, suboptimal muscle morphology is highly prevalent and correlates with more post-operative complications and chemotherapy toxicity [ 10 ] and increased mortality [ 11 ]. In a cross-sectional study conducted by our group, we observed significantly lower physical function and upper body strength in post-treatment OC survivors compared with age-matched controls [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Supervised resistance exercise for women with ovarian cancer who have completed first-line treatment: a pragmatic study

Schofield

Newton

Taaffe

et al. 2023

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Objectives In ovarian cancer (OC), suboptimal muscle morphology (i.e., low muscle mass and density) is associated with poor clinical outcomes, yet little is known about the effect of interventions aimed at improving these measures. We investigated the effect of resistance exercise after first-line treatment on muscle mass and density, muscle strength and physical function, health-related quality of life (QoL), and pelvic-floor function in advanced-stage OC survivors. Methods Fifteen OC survivors participated in supervised resistance exercise twice weekly for 12 weeks (in-clinic or by telehealth). Assessments included muscle mass and density (dual-energy X-ray absorptiometry, peripheral quantitative computed tomography), muscle strength (1-repetition maximum [1RM] chest press, 5RM leg press, handgrip strength), physical function (400-m walk, timed up-and-go [TUG]), QoL (QLQ-C30 questionnaire), and self-reported pelvic floor function (Australian Pelvic Floor Questionnaire). Results The median age was 64 (range 33–72) years, 10 women underwent neoadjuvant chemotherapy and five underwent adjuvant chemotherapy. All participants completed the intervention (median attendance = 92%; range 79–100%). Post-intervention improvements were observed for whole-body lean mass (1.0 ± 1.4 kg, p = 0.015), appendicular lean mass (0.6 ± 0.9 kg, p = 0.013), muscle density (p = 0.011), upper and lower body strength (p ≤ 0.001), 400-m walk (p = 0.001), TUG (p = 0.005), and social and cognitive QoL domains (p = 0.002 and 0.007), with no change to pelvic floor symptoms (p > 0.05). Conclusion In this study, supervised resistance exercise effectively improved muscle mass and density, muscle strength, and physical functioning without deleterious effects on the pelvic floor. Considering the prognostic value of these outcomes, larger studies are needed to confirm the benefits of resistance exercise in OC supportive care.

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Activity Behaviors and Physiological Characteristics of Women With Advanced-Stage Ovarian Cancer: A Preliminary Cross-sectional Investigation

Cited by 10 publications

References 41 publications

The comparison of functional status and health-related parameters in ovarian cancer survivors with healthy controls

The comparison of functional status and health-related parameters in ovarian cancer survivors with healthy controls

Barriers and enablers to participation in physical activity among women diagnosed with ovarian cancer

Supervised resistance exercise for women with ovarian cancer who have completed first-line treatment: a pragmatic study

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