Activity-Dependent Epigenetic Remodeling in Cocaine Use Disorder

López, Alberto J.; Siciliano, Cody A.; Calipari, Erin S.

doi:10.1007/164_2019_257

Cited by 9 publications

(10 citation statements)

References 208 publications

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“…In general, epigenetic mechanisms regulate chromatin in three ways: (1) nucleotide modifications (DNA and RNA); (2) histone modifications, whether at amino-terminal tails or through histone variant exchange; and (3) chromatin remodeling by ATP-dependent chromatin remodeling complexes [3]. The roles of histone modifications and DNA methylation in learning and memory have been reviewed considerably [4,[8][9][10][11][12][13]. Below, we focus on histone modification's role in memory, as their lysine targets can serve as recognition sites for ATP-dependent chromatin remodelers.…”

Section: Overviewmentioning

confidence: 99%

“…Drugs of abuse are known to induce widespread molecular adaptions throughout the nervous system, including long-lasting modifications to chromatin accessibility and gene expression through the recruitment of various histone-modifying enzymes, such as HATs, HDACs, and KMTs (for a full review of histone modifications in cocaine-associated behaviors see López et al 2020 [ 9 ]). For example, in response to acute cocaine, D1-MSNs show a significant upregulation of several permissive marks, such as H3K4me3, pH3S10, H3K14ac, and H4K5ac.…”

Section: Epigenetics In Substance Use Disordersmentioning

confidence: 99%

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The Emerging Role of ATP-Dependent Chromatin Remodeling in Memory and Substance Use Disorders

López

Hecking

White

2020

IJMS

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Long-term memory formation requires coordinated regulation of gene expression and persistent changes in cell function. For decades, research has implicated histone modifications in regulating chromatin compaction necessary for experience-dependent changes to gene expression and cell function during memory formation. Recent evidence suggests that another epigenetic mechanism, ATP-dependent chromatin remodeling, works in concert with the histone-modifying enzymes to produce large-scale changes to chromatin structure. This review examines how histone-modifying enzymes and chromatin remodelers restructure chromatin to facilitate memory formation. We highlight the emerging evidence implicating ATP-dependent chromatin remodeling as an essential mechanism that mediates activity-dependent gene expression, plasticity, and cell function in developing and adult brains. Finally, we discuss how studies that target chromatin remodelers have expanded our understanding of the role that these complexes play in substance use disorders.

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Section: Overviewmentioning

confidence: 99%

Section: Epigenetics In Substance Use Disordersmentioning

confidence: 99%

The Emerging Role of ATP-Dependent Chromatin Remodeling in Memory and Substance Use Disorders

López

Hecking

White

2020

IJMS

Self Cite

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“…Previous studies have consistently concluded that impulsivity was significantly associated with QOL, especially in a group of mental disorders characterized by impulsivity, such as bipolar disorder (9,22), attention deficit hyperactivity disorder (23,24) and emotional eating (25,26). In fact, although impulsivity has been shown to be a non-core symptom, in popular diagnostic systems (such as DSM-5 and ICD-11), certain impulsive behaviors can still be used to diagnose SUDs, such as uncontrolled drug seeking (27,28). Therefore, we hypothesized that the high impulsivity of patients with SUDs may have an impact on their QOL.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Patients With Methamphetamine Use Disorder: Relationship to Impulsivity and Drug Use Characteristics

et al. 2020

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Background: The quality of life (QOL) of patients with methamphetamine use disorder (MAUD) is increasingly recognized as an important outcome. Previous studies have found that impulsivity is negatively associated with QOL in mental disorders, but this relationship is rarely confirmed in patients with MAUD. We hypothesized that impulsivity is negatively correlated with QOL in patients with MAUD based on previous findings. In addition, a variety of drug use characteristics of patients that may potentially affect their QOL need to be further explored. Therefore, the purpose of this study was to explore the relationship between impulsivity, multiple drug use characteristics, and QOL in patients with MAUD. Methods: A total of 379 patients with MAUD were recruited, and the majority of them were male (85.5%), with an average age of 33.93 ± 7.08 years. Two psychiatrists conducted semi-structured interviews with methamphetamine (MA) users in two compulsory drug rehabilitation centers to obtain their demographics and drug use characteristics. The Barratt Impulsiveness Scale-11 (BIS-11) and Brief WHO Quality of Life Assessment (WHOQOL-BREF) were used to assess patients' impulsivity and QOL, respectively. Correlation and univariate regression analysis were used to explore the relationships between impulsivity, a series of drug use characteristics and patients' QOL in different domains. Further multiple linear regression analysis was used to identify what extent the above clinical variables explained the variations in patients' QOL. Results: Age, marital status, employment, and various drug use characteristics were significantly associated with at least one QOL domain. Among them, married and full-time job were positively correlated with QOL, while others were negatively correlated with QOL. The total score of BIS-11 was significantly negatively correlated with all four domains of QOL. Impulsivity, a range of drug use characteristics and certain

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“…Drugs of abuse induce transcriptional changes within the reward circuitry that underlie persistent alterations in neuronal function and, ultimately, drug-seeking behavior [1][2][3]. In the initial stages of drug use, drug-induced neuroadaptions that occur within the ventral tegmental area (VTA) are thought to be critical for developing addiction-like behaviors [4,5].…”

Section: Introductionmentioning

confidence: 99%

Cocaine induces paradigm-specific changes to the transcriptome within the ventral tegmental area

Campbell

Chen

Beardwood

et al. 2021

Neuropsychopharmacol.

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During the initial stages of drug use, cocaine-induced neuroadaptations within the ventral tegmental area (VTA) are critical for drug-associated cue learning and drug reinforcement processes. These neuroadaptations occur, in part, from alterations to the transcriptome. Although cocaine-induced transcriptional mechanisms within the VTA have been examined, various regimens and paradigms have been employed to examine candidate target genes. In order to identify key genes and biological processes regulating cocaine-induced processes, we employed genome-wide RNA-sequencing to analyze transcriptional profiles within the VTA from male mice that underwent one of four commonly used paradigms: acute home cage injections of cocaine, chronic home cage injections of cocaine, cocaine-conditioning, or intravenous-self administration of cocaine. We found that cocaine alters distinct sets of VTA genes within each exposure paradigm. Using behavioral measures from cocaine self-administering mice, we also found several genes whose expression patterns corelate with cocaine intake. In addition to overall gene expression levels, we identified several predicted upstream regulators of cocaine-induced transcription shared across all paradigms. Although distinct gene sets were altered across cocaine exposure paradigms, we found, from Gene Ontology (GO) term analysis, that biological processes important for energy regulation and synaptic plasticity were affected across all cocaine paradigms. Coexpression analysis also identified gene networks that are altered by cocaine. These data indicate that cocaine alters networks enriched with glial cell markers of the VTA that are involved in gene regulation and synaptic processes. Our analyses demonstrate that transcriptional changes within the VTA depend on the route, dose and context of cocaine exposure, and highlight several biological processes affected by cocaine. Overall, these findings provide a unique resource of gene expression data for future studies examining novel cocaine gene targets that regulate drug-associated behaviors.

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Activity-Dependent Epigenetic Remodeling in Cocaine Use Disorder

Cited by 9 publications

References 208 publications

The Emerging Role of ATP-Dependent Chromatin Remodeling in Memory and Substance Use Disorders

The Emerging Role of ATP-Dependent Chromatin Remodeling in Memory and Substance Use Disorders

Quality of Life in Patients With Methamphetamine Use Disorder: Relationship to Impulsivity and Drug Use Characteristics

Cocaine induces paradigm-specific changes to the transcriptome within the ventral tegmental area

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