Activity-guided isolation and identification of anti-staphylococcal components from Senecio tenuifolius Burm. F. leaf extracts

Manubolu, Manjunath; Goodla, Lavanya; Ravilla, Sivajyothi; Obulum, Vijayasarathi Reddy

doi:10.1016/s2221-1691(13)60048-9

Cited by 11 publications

(3 citation statements)

References 10 publications

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“…Their antimicrobial effect was explained with their ability to penetrate through the bacterial wall, because of their affinity with lipoteichoic acid, present in microbial membrane. Their ability to destroy the inner the membrane is probably due to their compatibility with hydrophilic and hydrophobic moieties [6,39,40,41]. These results suggest that the CT and SN1 alone or in combination could be useful to control the proliferation of pathogenic bacteria tested in this trial.…”

Section: Resultsmentioning

confidence: 93%

Effect of Chestnut Tannins and Short Chain Fatty Acids as Anti-Microbials and as Feeding Supplements in Broilers Rearing and Meat Quality

Mannelli

Minieri

Tosi

et al. 2019

Animals

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Simple SummaryThe poultry industry needs to replace antibiotics with natural or synthetic compounds able to overcome problems linked to the development of bacterial resistance. Tannins and short chain fatty acids are valid alternatives to contrast the growth of pathogens. However, tannins may induce detrimental effects on animal performances, especially in monogastrics, causing damage on gut villi. In contrast, short chain fatty acids are very efficient in influencing positively the morphology of small intestine wall. Hence, the aim of this trial was to develop a feeding strategy for broiler rearing, based on the use of chestnut tannins and short chain fatty acids administered as blends. No differences in animal performances or in meat quality were found among feeding groups. The results suggested that the mix of these supplements did not have negative effects on the productive performances, representing a promising alternative to antibiotics. However, further investigation is needed to better understand the effects of these supplements on animals in stress conditions.AbstractChestnut tannins (CT) and saturated short medium chain fatty acids (SMCFA) are valid alternatives to contrast the growth of pathogens in poultry rearing, representing a valid alternative to antibiotics. However, the effect of their blends has never been tested. Two blends of CT extract and Sn1-monoglycerides of SMCFA (SN1) were tested in vitro against the proliferation of Clostridium perfringens, Salmonella typhymurium, Escherichia coli, Campylobacter jejuni. The tested concentrations were: 3.0 g/kg of CT; 3.0 g/kg of SN1; 2.0 g/kg of CT and 1.0 g/kg of SN1; 1.0 g/kg of CT and 2.0 g/kg of SN1. Furthermore, their effect on broiler performances and meat quality was evaluated in vivo: one-hundred Ross 308 male birds were fed a basal diet with no supplement (control group) or supplemented with CT or SN1 or their blends at the same concentration used in the in vitro trial. The in vitro assay confirmed the effectiveness of the CT and SN1 mixtures in reducing the growth of the tested bacteria while the in vivo trial showed that broiler performances, animal welfare and meat quality were not negatively affected by the blends, which could be a promising alternative in replacing antibiotics in poultry production.

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Section: Resultsmentioning

confidence: 93%

Effect of Chestnut Tannins and Short Chain Fatty Acids as Anti-Microbials and as Feeding Supplements in Broilers Rearing and Meat Quality

Mannelli

Minieri

Tosi

et al. 2019

Animals

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“…Systematic screening of molecules such as antibacterial agents may lead to the discovery of new active ingredients (55). Different extracts of Senecio tenuifolius Burm plant were evaluated on MRSA and MSSA.…”

Section: Family Asteraceaementioning

confidence: 99%

A review on medicinal plant extracts and their active ingredients against methicillin-resistant and methicillin-sensitive Staphylococcus aureus

Askarinia

Ganji

Jadidi‐Niaragh

et al. 2019

J Herbmed Pharmacol

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Staphylococcus aureus is among the pathogens capable of developing a broad spectrum of infections in human beings. In addition to the hospital, the bacterium is present in the community and has a high resistance to antibiotics, which is also increasing on an ongoing basis. Resistance to β-lactam antibiotic family is one of the concerns about the bacterium that has encountered the treatment of such infections with difficulty. Due to the increased resistance and importance of this bacterium, new strategies are needed to control this pathogen. One of these approaches is the use of medicinal plants, which has attracted many researchers in the last decade. Several studies have been carried out or are being designed using various herbs to find active ingredients to deal with this bacterium. The aim of this study was to present the antibacterial activity of different medicinal plants and the effects of their active ingredients on methicillin-resistant and methicillin-sensitive S. aureus and to clarify the pathway to further studies in this regard.

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“…& Hiern has potential use to treat atherosclerosis, metabolic diseases such as hyperlipidemia and diabetes mellitus and neurodegenerative disorders [14] . S. tenuifolius DC has demonstrated antibacterial activity [15] , while S. smithioides Cabrera possess antiplasmodial compounds [16] .…”

Section: Introductionmentioning

confidence: 99%

Effects of Senecio selloi (Spreng.) DC flower extract on mitochondrial membrane peroxidation and enzyme activities

Becerra¹,

Gambaro²,

Padula³

et al. 2020

J Pharmacogn Phytochem

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Ethnobotanical use of plants may include poisonous species. Senecio (Asteraceae) is used as medicinal around the world. Senecio selloi (Spreng.) is widespread in Argentina. Purposes of this study were to investigate phytochemistry and in vitro activity of a methanolic extract of plant flowers on mitochondrial membrane peroxidation and enzyme activities. Chemiluminescence was used to test peroxidative effects, and thiazolyl blue tetrazolium bromide test (MTT) for cell viability. Results indicate presence of flavonoids and pyrrolizidine alkaloids. Regarding chemiluminescence, extract showed protective effect against peroxidation, while MTT demonstrated lower activities of mitochondrial dehydrogenases and cytosolic reductases, effects that were attributed to flavonoids and pyrrolizidine alkaloids, respectively. When ingested, pyrrolizidine alkaloids undergo hepatic biotransformation that cause damage to cells. On the contrary, toxicity does not take place when there is no metabolization. These situations may explain the ethnobotanical use of some poisonous senecios in human and veterinary medicine.

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Activity-guided isolation and identification of anti-staphylococcal components from Senecio tenuifolius Burm. F. leaf extracts

Cited by 11 publications

References 10 publications

Effect of Chestnut Tannins and Short Chain Fatty Acids as Anti-Microbials and as Feeding Supplements in Broilers Rearing and Meat Quality

Effect of Chestnut Tannins and Short Chain Fatty Acids as Anti-Microbials and as Feeding Supplements in Broilers Rearing and Meat Quality

A review on medicinal plant extracts and their active ingredients against methicillin-resistant and methicillin-sensitive Staphylococcus aureus

Effects of Senecio selloi (Spreng.) DC flower extract on mitochondrial membrane peroxidation and enzyme activities

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