This papers presents a flexible, user friendly, multi-tenant health care platform, which enables remote monitoring of vital signs of patients with Chronic Obstructive Pulmonary Disease (COPD) by integrating a series of heterogeneous data collection sources (medical devices), while offering to authorized professionals secure access to patients' Health Electronic Records (EHRs) in real time and from any location, further empowered by an automated alarm system. A pilot study, with duration of one year has been conducted in Greece to examine the degree to which patients adhere to the home rehabilitation protocol and its potential benefits for patients with COPD.