Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena

Kaspersen, Svein Jacob; Sundby, Eirik; Charnock, Colin; Hoff, Bård Helge

doi:10.1016/j.bioorg.2012.06.003

Cited by 20 publications

(12 citation statements)

References 46 publications

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“…Ring closure with oxalyl chloride afforded 7-deazaxanthines 49 in good overall yields. Debenzylation of selected deazaxanthines resulted in rigidins A−D (50) in excellent yields. 25 When oxalyl chloride was replaced by aryl or alkyl esters, C2aryl-and C2-alkyl-7-deazahypoxanthines 51 were obtained in variable yields.…”

Section: Introductionmentioning

confidence: 99%

Synthetic Entries to and Biological Activity of Pyrrolopyrimidines

et al. 2015

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This review summarizes recent literature (2000-2015) on the synthesis and pharmaceutical properties of pyrrolopyrimidines. These modified pyrimidine bases, fused to a pyrrole ring, and their corresponding nucleosides display a broad applicability in medicinal chemistry. This overview is divided into three main sections, according to the respective isomers: pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d]pyrimidines, and pyrrolo[3,4-d]pyrimidines. Each section contains a description of common retro-synthetic strategies, with particular attention for newly reported synthetic entries to the scaffold. Next, the synthetic strategies and the ways in which the scaffolds can be further modified are exemplified according to the biological properties of the obtained products.

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Section: Introductionmentioning

confidence: 99%

Synthetic Entries to and Biological Activity of Pyrrolopyrimidines

et al. 2015

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“…Among the vemembered N-heterocycles, pyrroles are considered as a privileged scaffold as they are found in natural products such as heme, chlorophyll, and vitamin B 12 . 73,74 These are the most likely ve-membered rings that can be constructed using NMSM. Therefore, this section has been devoted to the synthetic application of NMSM in the formation of vemembered nitrogen-containing heterocyclic systems.…”

Section: Synthesis Of Nitrogen-containing Heterocyclesmentioning

confidence: 99%

NitroketeneN,S-acetals: synergistic building blocks for the synthesis of heterocycles

Saigal

Khan

Rahman³

et al. 2019

RSC Adv.

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“…The protozoacidal activity of these compounds was very potent (Kaspersen et al, 2012). A series of diaryl ureas having a pyrrolo[2,3-d]pyrimidine were synthesized and were evaluated for their in vitro antiproliferative activities against human melanoma cell line.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Antimelanomal Activities of some Newly Synthesized Pyrrolotriazolopyrimidines and Pyrrolotetrazolopyrimidines and their Derivatives

Ibrahim¹,

Shehry²,

Hosni³

et al. 2015

International J. of Pharmacology

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A B S T R A C T A series of pyrrolo [2,3-d]pyrimidine, pyrrolotriazolopyrimidine and pyrrolotetrazolopyrimidine derivatives 2-13 were synthesized using 2-amino-1-(3-(trifluoromethyl)phenyl)-4,5-bis (4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile 1 as starting material. The biological rational upon which the newly synthesized compounds was built was their structural similarity with some pyrrole derivatives that having antimelanomal, anti-tetrahymena and some kinases inhibitor activities. Some of the newly synthesized compounds showed antimelanomal, anti-tetrahymena and some kinases inhibitor activities of the 124 kinases panel.

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Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena

Cited by 20 publications

References 46 publications

Synthetic Entries to and Biological Activity of Pyrrolopyrimidines

Synthetic Entries to and Biological Activity of Pyrrolopyrimidines

NitroketeneN,S-acetals: synergistic building blocks for the synthesis of heterocycles

Antimelanomal Activities of some Newly Synthesized Pyrrolotriazolopyrimidines and Pyrrolotetrazolopyrimidines and their Derivatives

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