Activity of andrographolide against dengue virus

Panraksa, Patcharee; Ramphan, Suwipa; Khongwichit, Sarawut; Smith, Duncan R.

doi:10.1016/j.antiviral.2016.12.014

Cited by 125 publications

(87 citation statements)

References 46 publications

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“…Panraksa et al. from Thailand observed that andrographolide had significant anti‐dengue virus activity and Tang et al. from Malaysia also found that the methanol extracts of A. paniculata possessed the ability of inhibiting the activity of dengue virus serotype 1 in in vitro assays .…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of plantar warts using topical Zijinding, a traditional Chinese medicine preparation: A case series

Zhao

Sridhar

Guo

et al. 2019

J of Cosmetic Dermatology

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Introduction Plantar warts are associated with high transmissibility and morbidity. Among the available therapeutic options, none is uniformly effective or virucidal. Salicylic acid is the first‐line therapy but approximately one‐third of lesions could not resolve and become recalcitrant despite repeated treatment. Cryotherapy is widely accessible with low cost but may be complicated by pain, blister formation, hemorrhage, infection, excessive granulation tissue formation, and hyper‐/hypo‐pigmentation. Hence, alternative treatment modalities are essential. Methods Three patients with debilitating plantar warts refractory or intolerant to cryotherapy were treated with a course of Zijinding (a traditional Chinese medicine preparation) paste prepared with white vinegar. Results All three patients showed excellent clinical response with Zijinding application with evolution of lesions to scabs and subsequently healthy skin within 1.5 to 5 months of treatment. Treatment was well tolerated and had no significant side effects with excellent compliance recorded for all three patients. There was no relapse for at least 10 months after stopping the treatment. Conclusion Topical Zijinding could be a promising alternative modality for the treatment of plantar warts. Further clinical trials on the comparison of Zijinding and other treatment modalities of plantar warts are warranted. Further studies are required to investigate the mechanism of action of Zijinding and to isolate the active ingredient.

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Section: Discussionmentioning

confidence: 99%

Successful treatment of plantar warts using topical Zijinding, a traditional Chinese medicine preparation: A case series

Zhao

Sridhar

Guo

et al. 2019

J of Cosmetic Dermatology

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“…In terms of dengue virus inhibitors, there are a wide variety of structure classes engaging various biological targets, that reveal a more even balance between synthetics and natural products . However, of the natural products only one diterpene, andrographolide ( 3 ) (Figure ), has been found to inhibit dengue virus both in vitro and in vivo (i.e., by inducing HO‐1 expression) …”

Section: Figurementioning

confidence: 99%

“…[9] How-ever,o ft he natural productso nly one diterpene, andrographolide (3)( Figure1), has been found to inhibit dengue virus both in vitro and in vivo (i.e.,byi nducing HO-1 expression). [10,11] In continuation of our program exploring the phytochemistry of Australian arid zone plants, [12] we collected Basilicum polystachyon,w hich is also found in Africa, Asia, and India. Extracts of this plant have been reported to induce ar ange of biological responses, which include antibacterial, [13] antimicrobial, [14,15] antifungal, [15] antioxidant [15] andc ytotoxic activity in biological assays.…”

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confidence: 99%

Stachyonic Acid: A Dengue Virus Inhibitor from Basilicum polystachyon

Tan

Houston

Modhiran

et al. 2019

Chemistry A European J

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Stachyonic acid A, arising from the first in‐depth phytochemical investigation of the herb Basilicum polystachyon, was found to display potent inhibitory activity against dengue virus, with limited cytotoxicity. Andrographolide, a known dengue virus inhibitor and closely related labdane‐type diterpene, is structurally more complex but displayed poor antiviral activity in the PRNT assay, and increased cytotoxicity in comparison. Furthermore, a Diels–Alder reaction with PTAD identified the active pharmacophore of stachyonic acid to be the conjugated diene.

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“…Furthermore, andrographolide (25, 50, 75, and 100 μM) exhibited significant cytotoxic effects on DENV 2-infected HepG2 and HeLa cells with EC 50 values of 21.30 and 22.74 μM, respectively. This compound was additionally found to exhibit activity against DENV serotype 4-infected HepG2 cell line (Panraksa, Ramphan, Khongwichit, & Smith, 2017). A very recent study was conducted in an attempt to further understand the mechanism of action of andrographolide in inhibiting DENV infection of liver cells using a proteomic based approach.…”

Section: Anti-denv Effects Of Diterpenes And/or Their Derivativesmentioning

confidence: 99%

Diterpenes and their derivatives as promising agents against dengue virus and dengue vectors: A literature‐based review

Islam

Mubarak

2019

Phytotherapy Research

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Dengue, a mosquito‐borne viral disease, causes about 100 million cases of infection annually. It is a major public concern, and if left untreated or improperly diagnosed, may cause serious health problems or even death. Historically, dengue has not considered priorities for pharmaceutical companies made the available treatment options. Therefore, medicinal scientists are revealing new insights and enabling novel interventions and approaches to dengue prevention and control. Diterpenes, a class of terpenes have gained much attention due to their diverse biological effects. This review aimed at summarizing available evidences of diterpenes and their derivatives acting against dengue virus and their vectors. For this, an updated search was made in the databases: PubMed and ScienceDirect by using specific keywords. Among the 117 published reports, a total of 30 articles was included in this review. Findings suggest that a number of diterpenes and/or their derivatives act against dengue virus and their two potential vectors namely Aedes aegypti and Ae. albopictus. In conclusion, diterpenes and their derivatives may have the potential alternative therapeutic tools for the management of dengue virus and some associated diseases transmitted by Aedes mosquito.

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Activity of andrographolide against dengue virus

Cited by 125 publications

References 46 publications

Successful treatment of plantar warts using topical Zijinding, a traditional Chinese medicine preparation: A case series

Successful treatment of plantar warts using topical Zijinding, a traditional Chinese medicine preparation: A case series

Stachyonic Acid: A Dengue Virus Inhibitor from Basilicum polystachyon

Diterpenes and their derivatives as promising agents against dengue virus and dengue vectors: A literature‐based review

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