1992
DOI: 10.4269/ajtmh.1992.47.378
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Activity of Azithromycin (CP-62,993) and Erythromycin against Chloroquine-Sensitive and Chloroquine-Resistant Strains of Plasmodium Falciparum in Vitro

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Cited by 49 publications
(28 citation statements)
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“…In vitro studies have shown that AZ has reasonably good activity against P. falciparum asexual blood-stage parasites, including CQR strains (7,30,58,63). This was confirmed in animal studies against CQS and CQR strains of rodent Plasmodium species (1,31,73).…”
supporting
confidence: 56%
“…In vitro studies have shown that AZ has reasonably good activity against P. falciparum asexual blood-stage parasites, including CQR strains (7,30,58,63). This was confirmed in animal studies against CQS and CQR strains of rodent Plasmodium species (1,31,73).…”
supporting
confidence: 56%
“…Experimental observations obtained in vitro (3,40) and in clinical studies (4,16) proved the antimalarial activity of doxycycline. Macrolide antibiotics, such as erythromycin and azithromycin, also have both in vitro activity against P. falciparum (11,13) and clinical activity (42,48). Similarly, fluoroquinolones were also proven to have antimalarial activity in vitro (19,56) and in vivo (50).…”
mentioning
confidence: 99%
“…The antimalarial effect of azithromycin in vitro was first reported in 1992 (12). Azithromycin targets the ribosome of susceptible microorganisms and reversibly inhibits protein synthesis (13).…”
Section: Discussionmentioning
confidence: 99%