Activity of budesonide on nasal neutrophilic inflammation and obstruction in children with recurrent upper airway infections

Bellodi, Simona; Tosca, Maria Angela; Pulvirenti, G; Petecchia, Loredana; Serpero, Laura D.; Silvestri, Michela; Sabatini, Federica; Battistini, Elena; Rossi, Giovanni A.

doi:10.1016/j.ijporl.2005.07.015

Cited by 14 publications

(5 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, COX-2 mRNA expression was ameliorated by BZYQT treatment and supports the antiinflammatory effect of BZYQT for the treatment of allergic rhinitis. From this study, we clearly demonstrated that antiallergic and antiinflammatory effects of BZYQT on non-acute stage of allergic rhinitis that is compatible with Price et al (2006), Bellodi et al (2006) and Failla et al (2006). These authors suggest that an approach aims to treat the airway inflammation is beneficial for the large proportion of patients who suffer from AR.…”

Section: Discussionsupporting

confidence: 51%

Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis

Yang

2008

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 51%

Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis

Yang

2008

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…In accordance with these studies, the current study has also demonstrated that short-term use of BIS nebulization is effective in delivering significant improvements in nasal symptoms and polyp size. The significant reduction in nasal obstruction and loss of smell scores may partly result from decreases in angiogenesis, blood flow and capillary bed permeability 2930…”

Section: Discussionmentioning

confidence: 99%

Comparison of Corticosteroids by 3 Approaches to the Treatment of Chronic Rhinosinusitis With Nasal Polyps

Zhang

Lou

Wang

et al. 2019

Allergy Asthma Immunol Res

View full text Add to dashboard Cite

Purpose Corticosteroids are regarded as the mainstay of medical treatment of eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). To date, a head-to-head comparison of the efficacy and safety of glucocorticoid preparations administered via different routes for the treatment of chronic rhinosinusitis with nasal polyps has not been reported. To compare the efficacy and safety of steroids administered via the oral, intranasal spray and transnasal nebulization routes in the management of ECRSwNP over a short course. Methods Overall, 91 patients with ECRSwNP were recruited prospectively and randomized to receive either oral methylprednisolone, budesonide inhalation suspension (BIS) via transnasal nebulization, or budesonide nasal spray (BNS) for 2 weeks. Nasal symptoms and polyp sizes were assessed before and after the treatment. Similarly, nasal polyp samples were evaluated for immunological and tissue remodeling markers. Serum cortisol levels were assessed as a safety outcome. Results Oral methylprednisolone and BIS decreased symptoms and polyp sizes to a significantly greater extent from baseline ( P < 0.05) than BNS. Similarly, BIS and oral methylprednisolone significantly reduced eosinophils, T helper 2 cells, eosinophil cationic protein, interleukin (IL)-5, and expression of matrix metalloproteinases 2 and 9, and significantly increased type 1 regulatory T cells, IL-10, transforming growth factor-β, and tissue inhibitor of metalloproteinases 1 and 2 in nasal polyps to a greater extent than BNS. Post-treatment serum cortisol levels were significantly decreased by oral methylprednisolone compared to BIS or BNS, which did not significantly alter the cortisol levels. Conclusions A short course of BIS transnasal nebulization is more efficacious compared to BNS in the management of ECRSwNP and is safer than oral methylprednisolone with respect to hypothalamic-pituitary-adrenal axis function.

show abstract

“…Following the database search, 544 articles were initially retrieved, and 8 articles with 2,327 patients were ultimately included in the meta-analysis. Articles were excluded if the pulmonary infection was caused by other primary diseases (10), the sample size was too small (11), or the outcome indicators were not examined (12). Figure 1 shows the selection flow chart.…”

Section: Article Screening Resultsmentioning

confidence: 99%

Safety of corticosteroids in the treatment of acute respiratory disease in children: a systematic review and meta-analysis

Yang¹,

Jin²

2022

Transl Pediatr

View full text Add to dashboard Cite

show abstract

Activity of budesonide on nasal neutrophilic inflammation and obstruction in children with recurrent upper airway infections

Cited by 14 publications

References 35 publications

Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis

Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis

Comparison of Corticosteroids by 3 Approaches to the Treatment of Chronic Rhinosinusitis With Nasal Polyps

Safety of corticosteroids in the treatment of acute respiratory disease in children: a systematic review and meta-analysis

Contact Info

Product

Resources

About