Activity of Colocasia esculenta (Taro) Corms against Gastric Adenocarcinoma Cells: Chemical Study and Molecular Characterization

Esposito, Tiziana; Pisanti, Simona; Mauro, Luciano; Mencherini, Teresa; Martinelli, Rosanna; Aquino, Rita Patrizia

doi:10.3390/ijms25010252

Cited by 4 publications

(1 citation statement)

References 57 publications

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“…GC is considered an aggressive malignancy characterized by uncontrolled cell proliferation and metastasis [8]. Globally, every year, more than 1 million people are diagnosed with GC [9,10].…”

Section: Introduction 1gastric Cancer Incidencementioning

confidence: 99%

Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer

Morgos,

Stefani,

Miricescu

et al. 2024

IJMS

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Gastric cancer (GC) is the fourth leading cause of death worldwide, with more than 1 million cases diagnosed every year. Helicobacter pylori represents the main risk factor, being responsible for 78% of the cases. Increased amounts of salt, pickled food, red meat, alcohol, smoked food, and refined sugars negatively affect the stomach wall, contributing to GC development. Several gene mutations, including PIK3CA, TP53, ARID1A, CDH1, Ras, Raf, and ERBB3 are encountered in GC pathogenesis, leading to phosphatidylinositol 3-kinase (PI3K) protein kinase B (AKT)/mammalian target of rapamycin (mTOR)—PI3K/AKT/mTOR—and mitogen-activated protein kinase (MAPK) signaling pathway activation and promoting tumoral activity. Helicobacter pylori, growth factors, cytokines, hormones, and oxidative stress also activate both pathways, enhancing GC development. In clinical trials, promising results have come from monoclonal antibodies such as trastuzumab and ramucirumab. Dual inhibitors targeting the PI3K/AKT/mTOR and MAPK signaling pathways were used in vitro studies, also with promising results. The main aim of this review is to present GC incidence and risk factors and the dysregulations of the two protein kinase complexes together with their specific inhibitors.

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Section: Introduction 1gastric Cancer Incidencementioning

confidence: 99%

Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer

Morgos,

Stefani,

Miricescu

et al. 2024

IJMS

View full text Add to dashboard Cite

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Phytochemical and chemotaxonomic investigations on the fruit parts of Illicium verum Hook. f

Li,

Yang,

Jin

et al. 2024

Biochemical Systematics and Ecology

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Anticancer Activity and Mechanism of Action of Couroupita guianensis Bark Decoction in Gastric Adenocarcinoma Cancer Cell Line

Pisanti,

Penna,

Sposito

et al. 2024

IJMS

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Couroupita guianensis, a medicinal plant autochthonal to South America and South India, is widely used in the ethnomedicine of the indigenous peoples of these regions thanks to its alleged antimicrobial, anti-inflammatory, antioxidant and wound-healing properties. The majority of studies have mainly analyzed organic extracts of the Indian plant’s flowers and leaves, with limited research on its bark decoction, traditionally used in Amazonian shamanic medicine. In this study, we investigated the anticancer effects of the bark decoction and its main fractions obtained through chromatographic separation, as well as the underlying molecular mechanisms in AGS gastric cancer cells. Viability, cell proliferation, cell cycle, apoptosis and protein expression related to these processes were evaluated. Both the bark decoction and fraction III significantly inhibited cell viability, and the cytotoxic effect was linked to cell cycle blockade and the induction of apoptosis also through an engulfment of the autophagic flux. Increased expression or activation of the key proteins (p53, p21, cdk2, Bak, caspases, pAMPK, pAkt, beclin, p62 and LC3BII) involved in these processes was observed. The results obtained confirmed an important anticancer effect of C. guianensis bark decoction, providing scientific validation for its use in traditional medicine and highlighting its potential as a therapeutic agent against gastric cancer.

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Activity of Colocasia esculenta (Taro) Corms against Gastric Adenocarcinoma Cells: Chemical Study and Molecular Characterization

Cited by 4 publications

References 57 publications

Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer

Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer

Phytochemical and chemotaxonomic investigations on the fruit parts of Illicium verum Hook. f

Anticancer Activity and Mechanism of Action of Couroupita guianensis Bark Decoction in Gastric Adenocarcinoma Cancer Cell Line

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