Activity of factor VII in patients with isolated blunt traumatic brain injury

Wu, Xing; Du, Zhuoying; Yu, Jian; Sun, Yirui; Pei, Bingbing; Lu, Xin; Tang, Zhengyu; Yin, Miao; Zhou, Lei; Hu, Jin

doi:10.1097/ta.0b013e3182a8fe48

Cited by 17 publications

(5 citation statements)

References 22 publications

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“…13,23 Thus, inhibition by antithrombin is not likely to provide an explanation for the observed hypocoagulability. 31 However, while loss of FVa was overtly apparent in all patients, it was not dependent on the severity of hypoperfusion. APC has become a well-recognized consequence of tissue hypoperfusion and shock as well as a known mediator of coagulopathy through inhibition of FV, FVIII, and plasminogen activator inhibitor type I.…”

Section: Discussionmentioning

confidence: 76%

Measuring thrombin generation as a tool for predicting hemostatic potential and transfusion requirements following trauma

Cardenas

Rahbar

Pommerening

et al. 2014

Journal of Trauma and Acute Care Surgery

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Section: Discussionmentioning

confidence: 76%

Measuring thrombin generation as a tool for predicting hemostatic potential and transfusion requirements following trauma

Cardenas

Rahbar

Pommerening

et al. 2014

Journal of Trauma and Acute Care Surgery

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“…15,22,23 According to Wu et al and clinical practice at our institute, coagulopathy was defined as thrombocytopenia (platelet count < 100,000/μl) or elevated international normalized ratio > 1.2 or prolonged activated partial thromboplastin time > 40 seconds at admission. 30 Surgical treatments and outcomes were reviewed from computer-based medical records. Patients were divided into five groups according to their Glasgow Outcome Scale (GOS) at the time of hospital discharge: 1 (death), 2 (persistent vegetative state), 3 (severe disability), 4 (moderate disability), and 5 (good recovery).…”

Section: Methodsmentioning

confidence: 99%

Blast-induced traumatic brain injury: the experience from a level I trauma center in southern Thailand

Tunthanathip¹,

Khocharoen²,

Phuenpathom³

2018

Neurosurgical Focus

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OBJECTIVEIn the ongoing conflict in southern Thailand, the improvised explosive device (IED) has been a common cause of blast-induced traumatic brain injury (bTBI). The authors investigated the particular characteristics of bTBI and the factors associated with its clinical outcome.METHODSA retrospective cohort study was conducted on all patients who had sustained bTBI between 2009 and 2017. Collected data included clinical characteristics, intracranial injuries, and outcomes. Factors analysis was conducted using a forest plot.RESULTSDuring the study period, 70 patients met the inclusion criteria. Fifty individuals (71.4%) were military personnel. One-third of the patients (32.9%) suffered moderate to severe bTBI, and the rate of intracerebral injuries on brain CT was 65.7%. Coup contusion was the most common finding, and primary blast injury was the most common mechanism of blast injury. Seventeen individuals had an unfavorable outcome (Glasgow Outcome Scale score 1–3), and the overall mortality rate for bTBI was 11.4%. In the univariate analysis, factors associated with an unfavorable outcome were preoperative coagulopathy, midline shift of the brain ≥ 5 mm, basal cistern effacement, moderate to severe TBI, hypotension, fixed and dilated pupils, surgical site infection, hematocrit < 30% on admission, coup contusion, and subdural hematoma. In the multivariable analysis, midline shift ≥ 5 mm (OR 29.1, 95% CI 2.5–328.1) and coagulopathy (OR 28.7, 95% CI 4.5–180.3) were the only factors predicting a poor outcome of bTBI.CONCLUSIONSbTBIs range from mild to severe. Midline shift and coagulopathy are treatable factors associated with an unfavorable outcome. Hence, in cases of bTBI, reversing an abnormal coagulogram is required as soon as possible to improve clinical outcomes. The management of brain shift needs further study.

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“…Many studies have argued that the poor outcomes organs following brain death were mainly associated with hemodynamic alterations (21,22), the release of inflammatory cytokines (23–25), consumption of coagulation factors (26,27) and endocrine and hormonal changes (28–30). However, the molecular mechanism underlying how the status of brain death organs influences the transplantation outcomes remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Proteomic analysis of differentially expressed proteins in kidneys of brain dead rabbits

et al. 2017

Molecular Medicine Reports

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A large number of previous clinical studies have reported a delayed graft function for brain dead donors, when compared with living relatives or cadaveric organ transplantations. However, there is no accurate method for the quality evaluation of kidneys from brain-dead donors. In the present study, two-dimensional gel electrophoresis and MALDI-TOF MS-based comparative proteomic analysis were conducted to profile the differentially-expressed proteins between brain death and the control group renal tissues. A total of 40 age- and sex-matched rabbits were randomly divided into donation following brain death (DBD) and control groups. Following the induction of brain death via intracranial progressive pressure, the renal function and the morphological alterations were measured 2, 6 and 8 h afterwards. The differentially expressed proteins were detected from renal histological evidence at 6 h following brain death. Although 904±19 protein spots in control groups and 916±25 in DBD groups were identified in the two-dimensional gel electrophoresis, >2-fold alterations were identified by MALDI-TOF MS and searched by NCBI database. The authors successfully acquired five downregulated proteins, these were: Prohibitin (isoform CRA_b), beta-1,3-N-acetylgalactosaminyltransferase 1, Annexin A5, superoxide dismutase (mitochondrial) and cytochrome b-c1 complex subunit 1 (mitochondrial precursor). Conversely, the other five upregulated proteins were: PRP38 pre-mRNA processing factor 38 (yeast) domain containing A, calcineurin subunit B type 1, V-type proton ATPase subunit G 1, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 and peroxiredoxin-3 (mitochondrial). Immunohistochemical results revealed that the expressions of prohibitin (PHB) were gradually increased in a time-dependent manner. The results indicated that there were alterations in levels of several proteins in the kidneys of those with brain death, even if the primary function and the morphological changes were not obvious. PHB may therefore be a novel biomarker for primary quality evaluation of kidneys from brain-dead donors.

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Activity of factor VII in patients with isolated blunt traumatic brain injury

Abstract: Prognostic study, level III.

Cited by 17 publications

References 22 publications

Measuring thrombin generation as a tool for predicting hemostatic potential and transfusion requirements following trauma

Measuring thrombin generation as a tool for predicting hemostatic potential and transfusion requirements following trauma

Blast-induced traumatic brain injury: the experience from a level I trauma center in southern Thailand

Proteomic analysis of differentially expressed proteins in kidneys of brain dead rabbits

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