Activity of fenbendazole against lung worms in naturally infected sheep

Eslami, A.; Anwar, M.

doi:10.1136/vr.99.7.129

Cited by 4 publications

(2 citation statements)

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“…in goats were 46%, 68%, and 99%, respectively [77]. Fenbendazole (20 mg/kg PO) was 100% effective against C. ocreatus in sheep [78]. These anthelmintic drugs, with the exception of fenbendazole, are no longer licensed, or available for use in livestock.…”

Section: Anthelminthic Drug Efficacymentioning

confidence: 99%

The Prevalence and Control of Lungworms of Pastoral Ruminants in Iran

et al. 2022

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Lungworms of the genera Dictyocaulus, Muellerius, Protostrongylus, and Cystocaulus are common helminths of domestic and wild ruminants with substantial veterinary and economic importance. Several studies have assessed the presence and prevalence of lungworm infections in ruminants in Iran. This report compiles the available scientific information about the occurrence of lungworms in domestic and wild ruminants in Iran between 1931 and June 2022 to give an insight into their epidemiology, and where possible to describe drug treatment efficacy. For this purpose, national and international scientific databases were searched. Overall, 54 publications comprising 33 articles in peer-reviewed journals, 8 conference papers, and 13 dissertations were evaluated regarding prevalence data; and an additional 4 peer-reviewed articles were evaluated regarding drug efficacy. Seven species of lungworms, namely Dictyocaulus filaria, Dictyocaulus viviparus, Dictyocaulus eckerti, Protostrongylus rufescens, Protostrongylus raillietti, Muellerius capillaris, and Cystocaulus ocreatus have been recorded from different ruminant hosts in Iran. Thirty-three studies conducted on small ruminant (sheep and goat) lungworms reported prevalences of lungworm infection of 11.6%, 45.81% and 66.29% using abattoir meat inspection, Baermann technique and fecal flotation, respectively. Eight studies conducted on large ruminants (cattle and water buffalo) reported prevalences of infection of 14.83%, 13.98% and 5% using abattoir meat inspection, the Baermann technique and fecal flotation, respectively. The prevalence of infection in wild ruminants was variable across examined species; 38% in urial, 37% in wild goats, 5% in goitered gazelles and 67% in red deer, in addition to a single case report in roe deer. There are few contemporary studies assessing the efficacy of currently available broad-spectrum anthelmintic compounds against lungworms in Iran. The high prevalence of multiple lungworm species in Iran, combined with a lack of information about drug efficacy, supports the need to improve the understanding of these important nematode parasites and inform the development of sustainable control strategies. The aim of this review and meta-analysis is to provide a baseline for future conventional parasitology and next generation molecular epidemiological studies of lungworm infection in pastoral ruminants in Iran.

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Section: Anthelminthic Drug Efficacymentioning

confidence: 99%

The Prevalence and Control of Lungworms of Pastoral Ruminants in Iran

et al. 2022

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“…Toxocara spp. (Toxocara canis, Toxocara cati and Toxascaris leonine) are parasitic roundworms (nematodes) of predatory mammals from families Canidae and Felidae with worldwide distribution [1,2]. T. canis is one of the most widespread public health and economically important zoonotic parasitic infections humans share with dogs, cats, and wild canids, particularly foxes and jackals [3].…”

Section: Introductionmentioning

confidence: 99%

Molecular evaluation of Toxocara infection in stray cats using loop-mediated isothermal amplification (LAMP) technique as a rapid, sensitive, and simple screening assay

Azimian

Shokrani

Fallahi

2020

Preprint

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Background: Toxocara species are parasitic nematodes of dogs and cats with a worldwide distribution. The adult worm lives in the intestine of dogs and cats, and infection occurs through eating paratenic host or embryonated eggs. These nematodes are considered as one of the common pathogens of humans and livestock, and in humans cause Visceral larva migrans (VLM) syndrome, which is accompanied by different clinical symptoms, sometimes lead to respiratory problems and even death. The present study aimed to investigate the molecular frequency of Toxocara species in stray cats using the loop-mediated isothermal amplification (LAMP) technique. Methods: During 3 months (July to September 2018) a total of 95 stool samples were randomly collected from stray cats in Khorramabad city, Lorestan province, West of Iran. To separate the parasite’s eggs, the flotation method with chlorine solution was applied to saturation. Microscopic examination was performed after the separation and extraction of supernatants. To rupture the four layers of Toxocara egg, and extraction of DNA, sonication and freeze and thaw processes were used. After DNA extraction from the stool specimens, the LAMP reaction was performed using the internal transcribed spacer 2 (ITS2) gene primers of Toxocara species and the appropriate LAMP master mix. Results: The overall prevalence of Toxocara spp. in stray cats of Khoramabad city was 20% (19/95) by parasitological and molecular assessments. The microscopic examination of stool samples revealed that 19 samples were positive for Toxocara spp. The same 19 positive samples were also positive in the LAMP experiments. Interestingly, based on the results of the LAMP assay, out of 95 studied samples, 18 (18.41%) specimens were belonged to Toxocara canis, while only 1 (0.5%) sample was diagnosed as Toxocara cati. Conclusion: Identification of Toxocara spp. in dogs and cats as the important sources of human infections especially for children is particularly important. The relatively high prevalence of Toxocara species, especially and interestingly the canis species in the studied cats shows the role of these animals in spreading the disease and the risk of transmission of infection to humans. Precautionary measures such as preventing cats from traveling in public places, especially children's playgrounds, as well as avoiding direct contact with stray cats are recommended.

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Chapter 15. Antiparasitic Agents

Wang

Fisher

1977

Annual Reports in Medicinal Chemistry

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Activity of fenbendazole against lung worms in naturally infected sheep

Cited by 4 publications

References 0 publications

The Prevalence and Control of Lungworms of Pastoral Ruminants in Iran

The Prevalence and Control of Lungworms of Pastoral Ruminants in Iran

Molecular evaluation of Toxocara infection in stray cats using loop-mediated isothermal amplification (LAMP) technique as a rapid, sensitive, and simple screening assay

Chapter 15. Antiparasitic Agents

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