Activity of fungicide cyclobutrifluram against Fusarium fujikuroi and mechanism of the pathogen resistance associated with point mutations in FfSdhB, FfSdhC2 and FfSdhD

Sun, Yang; Liu, Yu; Zhou, Li; Liu, Xinyan; Wang, Kun; Chen, Xing; Zhang, Chuanqing; Chen, Yu

doi:10.1016/j.jia.2024.01.004

Journal of Integrative Agriculture

2024

DOI: 10.1016/j.jia.2024.01.004

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Activity of fungicide cyclobutrifluram against Fusarium fujikuroi and mechanism of the pathogen resistance associated with point mutations in FfSdhB, FfSdhC2 and FfSdhD

Yang Sun,

Yu Liu,

Li Zhou

et al.

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Functional analysis of all succinate dehydrogenase subunits in Fusarium fujikuroi

Fan,

Qi,

Shao

et al. 2024

Phytopathol Res

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Fusarium fujikuroi, the causal agent of rice bakanae disease (RBD), contains five succinate dehydrogenase (Sdh) subunits: FfSdhA, FfSdhB, FfSdhC1, FfSdhC2, and FfSdhD. However, the role of these subunits in regulating sensitivity to succinate dehydrogenase inhibitors (SDHIs) is largely unknown. Here, we conducted targeted gene disruption and phenotypic assays for all Sdh subunits and found that the deletion mutants of FfSdhA, FfSdhB, and FfSdhD exhibited severe defects in hyphal growth, conidiation, virulence, and sensitivity to CaCl2 and oxidative stresses. To a lesser extent, the mycelial growth rate and conidial production of ΔFfSdhC1 were also decreased as compared to those of the wild-type strain JS16. In addition, fungicide sensitivity assays showed that deletion of FfSdhA, B, C1, or D led to decreased sensitivity to all SDHIs tested. Unexpectedly, we were unable to obtain a FfSdhC1 + C2 double mutant and further found significant up-regulation of FfSdhC2 in ∆FfSdhC1, indicating that FfSdhC1 and -C2 might be essential for fungal growth although the FfSdhC2 deletion mutant was indistinguishable from the wild-type strain. These findings provide useful information for enhancing our understanding of the biological functions of the Sdh subunits in pathogenic fungi.

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Functional analysis of all succinate dehydrogenase subunits in Fusarium fujikuroi

Fan,

Qi,

Shao

et al. 2024

Phytopathol Res

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Activity of fungicide cyclobutrifluram against Fusarium fujikuroi and mechanism of the pathogen resistance associated with point mutations in FfSdhB, FfSdhC2 and FfSdhD

Cited by 1 publication

References 45 publications

Functional analysis of all succinate dehydrogenase subunits in Fusarium fujikuroi

Functional analysis of all succinate dehydrogenase subunits in Fusarium fujikuroi

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