Activity of gatifloxacin and ciprofloxacin in combination with other antimicrobial agents

Gradelski, Elizabeth; Kolek, B; Bonner, Daniel P.; Valera, Lourdes; Minassian, Beatrice; Fung‐Tomc, Joan

doi:10.1016/s0924-8579(00)00317-4

Cited by 43 publications

(28 citation statements)

References 4 publications

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“…Although antimicrobial synergy appears to be best established for ␤-lactam-aminoglycoside combinations, similar data on synergistic activity have emerged for combinations of ␤-lactams and fluoroquinolones (14,50,77,96,99,132,168,183,189,205,252,253). In vitro synergy between ␤-lactams and fluoroquinolones against Gram-negative organisms has ranged from 17% to 82% (96,119,168).…”

Section: Synergymentioning

confidence: 99%

Combination Therapy for Treatment of Infections with Gram-Negative Bacteria

2012

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SUMMARY Combination antibiotic therapy for invasive infections with Gram-negative bacteria is employed in many health care facilities, especially for certain subgroups of patients, including those with neutropenia, those with infections caused by Pseudomonas aeruginosa , those with ventilator-associated pneumonia, and the severely ill. An argument can be made for empiric combination therapy, as we are witnessing a rise in infections caused by multidrug-resistant Gram-negative organisms. The wisdom of continued combination therapy after an organism is isolated and antimicrobial susceptibility data are known, however, is more controversial. The available evidence suggests that the greatest benefit of combination antibiotic therapy stems from the increased likelihood of choosing an effective agent during empiric therapy, rather than exploitation of in vitro synergy or the prevention of resistance during definitive treatment. In this review, we summarize the available data comparing monotherapy versus combination antimicrobial therapy for the treatment of infections with Gram-negative bacteria.

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Section: Synergymentioning

confidence: 99%

Combination Therapy for Treatment of Infections with Gram-Negative Bacteria

2012

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“…The synergistic effects of helvolic acid and antibiotics were investigated using the checkerboard method (Cappelletty & Rybak, 1996;Gradelski et al, 2001). Helvolic acid was added respectively in two-fold serial antibiotic dilutions in Mueller-Hinton broth, and bacterial cell suspensions were inoculated as described previously (Gradelski et al, 2001).…”

Section: Mic Determinations and Checkerboard Testingmentioning

confidence: 99%

“…Helvolic acid was added respectively in two-fold serial antibiotic dilutions in Mueller-Hinton broth, and bacterial cell suspensions were inoculated as described previously (Gradelski et al, 2001). After incubation, the combinations that inhibited visible growth were recorded.…”

Section: Mic Determinations and Checkerboard Testingmentioning

confidence: 99%

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In vitrosynergistic antibacterial activities of helvolic acid on multi-drug resistantStaphylococcus aureus

Qin

Guan

et al. 2009

Natural Product Research

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“…The combination activities of each FQ with CLR against different MAC strains were studied by employing the checkerboard titration technique with 7H9 broth medium (7). Checkerboard titration was performed in 96-well microplates with a final volume of 200 l. The MICs of all the antibiotics were predetermined before the checkerboard titration was performed.…”

Section: Microorganismsmentioning

confidence: 99%