Activity of ivermectin long-acting injectable (IVOMEC® GOLD) in first-season grazing cattle exposed to natural challenge conditions in Germany

Rehbein, Steffen; Knaus, Martin; Visser, Martin; Winter, Renate; Yoon, Stephen; Anderson, A.; Cramer, Luiz G.

doi:10.1007/s00436-014-4158-4

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…With respect to the efficacy profile of IVM LAI, which provides effective control of nematode infections in cattle for up three months [ 53 , 54 ] and the high sensitivity of Hypoderma spp. to macrocyclic lactones in general [ 42 ] and ivermectin in particular [ 55 , 56 ], it can be assumed that IVM LAI while the flies are at the adult developmental stage will also provide protection against cattle Hypoderma spp.…”

Section: Discussionmentioning

confidence: 99%

Treatment and control of bovine hypodermosis with ivermectin long-acting injection (IVOMEC® GOLD)

Otranto

Johnson

Syvrud³

et al. 2016

Parasites Vectors

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BackgroundThe studies reported here were conducted to assess the efficacy of ivermectin long-acting injection (IVM LAI; IVOMEC® GOLD, Merial; 3.15 % w/v ivermectin) for the treatment and control of natural infestations of cattle by Hypoderma bovis and Hypoderma lineatum, which are the most economically important oestrid flies of cattle in the northern hemisphere.MethodsCattle selected from herds with a history of Hypoderma infestation were grouped into blocks of three (Italy, 33 cattle; Germany, 30 cattle) or two (USA, 16 cattle) animals each, on the basis of positivity at the pre-treatment anti-Hypoderma antibody titres. Within each block, animals were randomly allocated to one of the following treatment regimens: saline (control); IVM LAI, administered at the predicted time of occurrence of first-instar larvae (Italy, Germany, USA); IVM LAI, administered at the predicted time of occurrence of second- and/or third-instar larvae (Italy, Germany). All treatments were administered by subcutaneous injection in correspondence of the area anterior to the shoulder at 1 ml/50 kg body weight, which corresponds to 630 mcg IVM/kg for IVM LAI.ResultsNo Hypoderma larvae emerged from animals treated with IVM LAI, whereas live H. lineatum (Italy) or H. bovis (Germany, USA) larvae were collected from saline-treated animals (P < 0.01). No adverse reactions to treatments were in any of the animals enrolled in the study.ConclusionsThe results from this study demonstrate that ivermectin in a long-acting formulation is 100 % efficacious in the treatment of cattle naturally infested by H. bovis and H. lineatum larvae at all stages of development. IVM LAI can, therefore, be used as ‘prophylactic’ treatment for Hypoderma spp. infestations in absence of external evidence of their presence and thus prior to skin and carcass damage, and as ‘therapeutic’ treatment, when warbles are already present.

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Section: Discussionmentioning

confidence: 99%

Treatment and control of bovine hypodermosis with ivermectin long-acting injection (IVOMEC® GOLD)

Otranto

Johnson

Syvrud³

et al. 2016

Parasites Vectors

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“…It is particularly important to consider the cattle owners’ perception of ETC, as endectocides have long been used for control of both ecto- and endo-parasites that reduce productivity (e.g., low efficiency of feed conversion, weight gain and milk production) and cause economic losses 21,22,48 . Treatment of livestock with endectocides has also been successful against Tse tse flies in sub-Saharan Africa 49 , tick-borne diseases worldwide, and a variety of other biting and/or nuisance insects including flies, biting midges, mites and lice 22 . At approved labeled doses, topically or systemically applied endectocides provide the sufficient and/or sustained dosage required for reduction of mosquito survival rate below elimination threshold 50,51 .…”

Section: Discussionmentioning

confidence: 99%

Mapping the potential use of endectocide-treated cattle to reduce malaria transmission

Imbahale

Lopez

Brew

et al. 2019

Sci Rep

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Treating cattle with endectocide is a longstanding veterinary practice to reduce the load of endo and ectoparasites, but has the potential to be added to the malaria control and elimination toolbox, as it also kills malaria mosquitoes feeding on the animals. Here we used openly available data to map the areas of the African continent where high malaria prevalence in 2–10 year old children coincides with a high density of cattle and high density of the partly zoophilic malaria vector Anopheles arabiensis . That is, mapping the areas where treating cattle with endectocide would potentially have the greatest impact on reducing malaria transmission. In regions of Africa that are not dominated by rainforest nor desert, the map shows a scatter of areas in several countries where this intervention shows potential, including central and eastern sub-Saharan Africa. The savanna region underneath the Sahel in West Africa appears as the climatic block that would benefit to the largest extent from this intervention, encompassing several countries. West Africa currently presents the highest under-10 malaria prevalence and elimination within the next twenty years cannot be contemplated there with currently available interventions alone, making the use of endectocide treated cattle as a complementary intervention highly appealing.

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Control of parasitic infection with ivermectin long-acting injection (IVOMEC® GOLD) and production benefit in first-season grazing cattle facing a high-level larval challenge in Germany

Rehbein¹,

Knaus²,

Visser³

et al. 2016

Parasitol Res

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Gastrointestinal and pulmonary nematode infections are affecting the health and productivity of grazing cattle worldwide. To evaluate the effects of a single treatment with ivermectin long-acting injection (IVM LAI; IVOMEC® GOLD, Merial; 3.15 % ivermectin w/v) in first-grazing season cattle, two studies were conducted under continued stocking conditions for 84 or 100 days in Bavaria, Germany. Each study involved 68 naturally infected, approximately 4- to 6-month-old Brown Swiss bull calves. Animals were blocked based on pretreatment body weights. Within each block of four animals, animals were randomly assigned to treatments: one to saline (control) and three to IVM LAI. Treatments were injected at 1 mL/50 kg body weight subcutaneously in front of the shoulder. Animals in both studies were managed as one herd each grazing together. Cattle were weighed and fecal samples were collected pretreatment and at intervals thereafter for determination of weight gain and treatment efficacy, respectively. Fecal examination including composite fecal culture indicated the presence of nematodes of the genera Cooperia (dominating), Haemonchus, Nematodirus, Ostertagia, Strongyloides, Trichostrongylus, Trichuris, and Dictyocaulus, and Moniezia cestodes in the cattle. Following treatment, IVM LAI-treated cattle did not shed any Dictyocaulus larvae for 84 days while controls continued to pass larvae. Compared to the controls, IVM LAI-treated cattle had significantly (p < 0.01) lower strongylid egg counts at each occasion. Percentage reductions were ≥94 % up to 70 days after treatment and were ≥83.9 and 58.9 % at 84 and 100 days. Over the 84- or 100-day study periods, IVM LAI-treated cattle gained significantly more weight than the controls: 22.7 and 12.4 kg, respectively. The two studies demonstrated a high efficacy of IVM LAI against gastrointestinal and pulmonary nematode infections under field conditions in Germany which was associated with significant benefit as to weight gain.

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Activity of ivermectin long-acting injectable (IVOMEC® GOLD) in first-season grazing cattle exposed to natural challenge conditions in Germany

Cited by 7 publications

References 27 publications

Treatment and control of bovine hypodermosis with ivermectin long-acting injection (IVOMEC® GOLD)

Treatment and control of bovine hypodermosis with ivermectin long-acting injection (IVOMEC® GOLD)

Mapping the potential use of endectocide-treated cattle to reduce malaria transmission

Control of parasitic infection with ivermectin long-acting injection (IVOMEC® GOLD) and production benefit in first-season grazing cattle facing a high-level larval challenge in Germany

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