ACTIVITY OF LYMPHOID RECEPTORS OF LYMPHOPROLIFERATION AND APOPTOSIS IN THE PHYSIOLOGICAL REGULATION OF IMMUNE HOMEOSTASIS IN HUMAN ADAPTATION TO CHANGING ENVIRONMENTAL CONDITIONS (Review)

Филиппова, О. Е.; Popovskaya, Ekaterina; Шашкова, Е Ю; Shchegoleva, L. S.

doi:10.17238/issn2308-3174.2016.1.87

Cited by 2 publications

(2 citation statements)

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“…It is known that starving, accompanied by a decrease of body mass, inhibits the activity of the immune system and in particular the cell-mediated immunity [38].…”

Section: Discussionmentioning

confidence: 99%

The Cyclic Feeding Regime Induces Decaying Age-Dependent Oxidative Stress and Regulates the Cell Chain of the Immunity

Божков¹,

Nikitchenko²,

Lebed³

et al. 2016

AAR

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We developed an experimental model of a cyclic feeding regime (CFR) that increased a lifespan in rats. The manifestations of oxidative stress and their interrelation with parameters of cell immunity were assessed in rats at CFR. It is shown that changes of body mass, liver mass and indexes of pro/antioxidant system after periods of starving-ad libitum nutrition at CFR diet in old animals were less pronounced than in young animals. The body mass loss of 30% in 14 days was accompanied by oxidative stress. Indexes of phagocytosis did not change, but activity of oxidase system of neutrophil was increased in 2 times. The response of metabolic and physiological systems on repeat starving-ad libitum nutrition cycles differs from the response to the initial cycle of CFR. This is interpreted as a change of adaptation strategy and the effect of metabolic memory, which influences the choice of organism strategy of adaptation for subsequent starving. The dynamics of change of the studied indexes in response to CFR was age-dependent. It was supposed that different answer to CFR in young and old animals is determined by the different amount of carbon and fat depots in young and old animals.

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“…It is known that starving, accompanied by a decrease of body mass, inhibits the activity of the immune system and in particular the cell-mediated immunity [38].…”

Section: Discussionmentioning

confidence: 99%

The Cyclic Feeding Regime Induces Decaying Age-Dependent Oxidative Stress and Regulates the Cell Chain of the Immunity

Божков¹,

Nikitchenko²,

Lebed³

et al. 2016

AAR

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“…В процессе сложных взаимодействий иммунокомпетентных клеток конечный эффект зависит не только от функциональной активности клеток, их количества, но и от их соотношения субпопуляций иммунных клеток [21]. Нами выявлено увеличение ИРИ.…”

Section: оригинальные исследованияunclassified

Influence of Low Level Laser Therapy on Immunological Parameters in Patients With Phlegmon of the Maxillofacial Region and Neck

Cherniak¹,

Harelik²,

Haretskaya³

et al. 2023

Journal GrGMU

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Background. The problem of treatment of phlegmon of the maxillofacial region and neck remains one of the most urgent problems of maxillofacial surgery. Aim. To determine the degree of influence of local Low Level Laser Therapy (LLLT) on the quantitative and functional characteristics of immunocytes and humoral factors in peripheral blood and lavage fluid in phlegmon of the maxillofacial region and neck. Material and methods. We have examined and treated 60 patients with phlegmon of the maxillofacial region and neck. Of these, 30 people made up group 1 – traditional treatment and 30 people were included into group 2 (traditional treatment supplemented with local LLLT). Also, 12 practically healthy individuals were examined to determine the regional norm of the selected indicators (control group). The total number of leukocytes and their subpopulations were determined in the blood and lavage fluid, immunophenotyping of lymphocytes was performed using monoclonal antibodies (CD3+, CD4+, CD8+, CD16+, CD19+, CD25+, CD95+), determination of the phagocytic index (PhI) and phagocytic number (PhN), the study of hemolytic complement activity (CH50), the presence of circulating immune complexes (CIC) and the level of immunoglobulins (Ig) of classes M, A, G. Results. Weekly local exposure of LLLT contributed to a decrease in leukocytes and neutrophils in the blood with an increase in their functional activity (PhN), an increase in the number of lymphocytes, levels of IgM, IgG, while reducing CH50 in blood serum. In the lavage fluid under the influence of LLLT, a decrease in leukocytes, neutrophils, activation of phagocytosis, an increase in lymphocytes due to the number of CD3+ and CD4+ T-lymphocytes, a decrease in CD8+ of cytostatic T-lymphocytes, CD25+ activated T- and B-lymphocytes, CD95+T- and B-lymphocytes, decrease in CH50, IgM level and increase in IgG were revealed. Conclusion. Comprehensive treatment of patients with phlegmon of the maxillofacial region supplemented with LLLT has a modulating effect on cellular and humoral immunity factors by enhancing the local immune response.

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ACTIVITY OF LYMPHOID RECEPTORS OF LYMPHOPROLIFERATION AND APOPTOSIS IN THE PHYSIOLOGICAL REGULATION OF IMMUNE HOMEOSTASIS IN HUMAN ADAPTATION TO CHANGING ENVIRONMENTAL CONDITIONS (Review)

Cited by 2 publications

References 0 publications

The Cyclic Feeding Regime Induces Decaying Age-Dependent Oxidative Stress and Regulates the Cell Chain of the Immunity

The Cyclic Feeding Regime Induces Decaying Age-Dependent Oxidative Stress and Regulates the Cell Chain of the Immunity

Influence of Low Level Laser Therapy on Immunological Parameters in Patients With Phlegmon of the Maxillofacial Region and Neck

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