Activity of medicinal plants from Ghana against the parasitic gut protist Blastocystis

Christensen, Charlotte Bremer; Soelberg, Jens; Stensvold, Christen Rune; Jäger, Anna K.

doi:10.1016/j.jep.2015.03.006

Cited by 21 publications

(12 citation statements)

References 55 publications

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“…Also, El Wakil [ 144 ], in 2007, showed that an aqueous extract of Nigella sativa significantly inhibits the growth of Blastocystis isolates. In addition, some medicinal plants from Ghana and Thailand showed high activity against Blastocystis [ 145 , 146 ]. Similarly, supplementation with 600 mg emulsified oil of Mediterranean oregano ( Origanum vulgare ) daily lead to the complete disappearance of Blastocystis [ 147 ].…”

Section: The Influence Of Different Diets On Blastocystis mentioning

confidence: 99%

Blastocystis: how do specific diets and human gut microbiota affect its development and pathogenicity?

Lepczyńska

Białkowska

Dzika

et al. 2017

Eur J Clin Microbiol Infect Dis

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Blastocystis is an enteric parasite that inhabits the gastrointestinal tract of humans and many animals. This emerging parasite has a worldwide distribution. It is often identified as the most common eukaryotic organism reported in human fecal samples. This parasite is recognized and diagnosed more often than ever before. Furthermore, some strains develop resistance against currently recommended drugs, such as metronidazole; therefore, the use of natural remedies or special diets has many positive aspects that may address this problem. The goal of this review is to compare natural treatments and various diets against the efficacy of drugs, and describe their influence on the composition of the gut microbiota, which affects Blastocystis growth and the occurrence of symptoms. This article reviews important work in the literature, including the classification, life cycle, epidemiology, pathogenesis, pathogenicity, genetics, biology, and treatment of Blastocystis. It also includes a review of the current knowledge about human gut microbiota and various diets proposed for Blastocystis eradication. The literature has revealed that garlic, ginger, some medical plants, and many spices contain the most effective organic compounds for parasite eradication. They work by inhibiting parasitic enzymes and nucleic acids, as well as by inhibiting protein synthesis. The efficacy of any specific organic compound depends on the Blastocystis subtype, and, consequently, on its immunity to treatment. In conclusion, the article discusses the findings that human gut microbiota composition triggers important mechanisms at the molecular level, and, thus, has a crucial influence on the parasitic pathogenicity.

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Section: The Influence Of Different Diets On Blastocystis mentioning

confidence: 99%

Blastocystis: how do specific diets and human gut microbiota affect its development and pathogenicity?

Lepczyńska

Białkowska

Dzika

et al. 2017

Eur J Clin Microbiol Infect Dis

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“…Most Launaea species are used in traditional medicine around the globe, as a stomachic, lactagogue, soporific, and insect repellent, and to treat diarrhoea, gastrointestinal disorders, fever, inflammation, infected wounds, skin diseases, and hepatic pains. Different extracts of Launaea species have been reported to exhibit antimicrobial, antioxidant, antiparasitic, neuroprotective, antiurolithiatic, anticancer, allelopathic, and insecticidal activities . Chemically, several metabolites were reported from these plants, including sesquiterpene lactones, triterpenoid saponin, terpenoids, steroids, coumarins, flavonoids, and phenolics, as well as essential oils …”

Section: Introductionmentioning

confidence: 99%

Interspecific variation, antioxidant and allelopathic activity of the essential oil from three Launaea species growing naturally in heterogeneous habitats in Egypt

Elshamy

Abd‐ElGawad

El‐Amier

et al. 2019

Flavour & Fragrance J

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Essential oils (EOs) from the aerial parts of three Launaea species collected from two different habitats were extracted [Launaea mucronata collected from coastal desert (LMC) and from inland desert (LMD), Launaea nudicaulis collected from coastal desert (LNC) and from inland desert (LND), Launaea spinosa (LS)]. The EOs were analysed by gas chromatography mass spectrometry (GC‐MS) and tested for antioxidant activity as well for allelopathic activity against purslane. A total of 117 compounds were identified from all samples, including 64 from LS, 50 from LMC, 39 from LMD, 24 from LNC, and 20 from LND, representing 100% of the total oil mass. The oxygenated sesquiterpenes were the major compounds of the EOs from LS, LMC, LMD, LNC, and LND, representing 62.73, 61.02, 58.35, 43.22, and 48.33%, respectively, whereas the monoterpene hydrocarbons were minor compounds in all samples. α‐Acorenol (31.42%), trans‐longipinocarveol (12.04%), and γ‐eudesmol (6.31%) represented the major compounds of the EO from LS, whereas hexahydrofarnesyl acetone and n‐heneicosane represented the major compounds from LMC, LMD, LNC, and LND. Correlations between the EOs of the five samples were studied via principal component analysis and agglomerative hierarchical clustering, based on the chemical composition of the EOs. There was a significant variation between Launaea species regarding both the quality and the quantity of EO composition, whereas no significant difference was observed based on the habitats (coastal and inland deserts). The EOs of the five Launaea samples exhibited meaningful antioxidant activities, as follows: LND > LNC > LMD > LMC > LS. Moreover, the EOs of the five Lanaea samples exhibited significant allelopathic activity against purslane weed in a concentration‐dependent manner. LMD and LMC showed the highest effect, with germination inhibition of 96.1 and 87.9% at 250 μL L−1, and radicle growth inhibition of 92.6 and 89.7%, but LS was the least effective extract. Our results showed that the variation in the quality and quantity of EO composition is mainly species specific, with a slight correlation with habitats.

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“…Moreover, another research work about the essential oil composition of L. nudicaulis grown in Oman has also been published [20]. Crude extracts, including water extracts, of Launaea species were also tested for their antibacterial [13,15,21] , antifungal [22] , antiparasitic [23] , nephroprotective [24] , antiurolithiatic [25] , antioxidant [26] and allelopathic [27] activities. This work deals with the essential oil composition and antibacterial activity of L. lanifera grown in Algeria, never previously studied.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and antibacterial activity of essential oil of Launaea lanifera Pau grown in Algerian arid steppes

Benmeddour

Laouer

Akkal

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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Objective: To evaluate the essential oil composition and the antibacterial activity of an\ud Algerian endemic plant, Launaea lanifera Pau (L. lanifera), grown in arid steppe regions.\ud Methods: L. lanifera essential oil was isolated from aerial parts by steam distillation and\ud its chemical composition was evaluated by gas chromatography-flame ionization detector\ud and gas chromatography with electron impact mass spectrometry. Furthermore, its\ud in vitro antibacterial activity against four bacterial strains was tested following the agar\ud disk diffusion method.\ud Results: This species had a very low essential oil yield (0.005%). Twenty-four (92.6%)\ud individual components were identified. The main constituents were hexahydrofarnesyl\ud acetone (31.6%), (E)-b-ionone (8.5%), (E)-b-damascenone (7.0%), 2-methyltetradecane\ud (3.8%), n-heptadecane (3.8%), limonene (2.8%) and b-caryophyllene (2.8%). No noteworthy\ud antimicrobial activity was observed on the tested bacteria, neither Gram negative\ud nor Gram positive.\ud Conclusions: This is the first report on the volatile constituents and antibacterial activity\ud of L. lanifera. The studied essential oil does not possess significant activity against the\ud tested microorganisms

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Activity of medicinal plants from Ghana against the parasitic gut protist Blastocystis

Cited by 21 publications

References 55 publications

Blastocystis: how do specific diets and human gut microbiota affect its development and pathogenicity?

Blastocystis: how do specific diets and human gut microbiota affect its development and pathogenicity?

Interspecific variation, antioxidant and allelopathic activity of the essential oil from three Launaea species growing naturally in heterogeneous habitats in Egypt

Chemical composition and antibacterial activity of essential oil of Launaea lanifera Pau grown in Algerian arid steppes

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