Activity of phosphatases and succinic dehydrogenase in the trigeminal ganglion of the corticosteroid-treated mouse

Silbermann, Michael; Finkelbrand, Sara

doi:10.1159/000144903

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…Dual embryonic origin (of epidermal placode and of neural crest origin) (Hamburger, 1961), as fixation artifacts (Cammermeyer, 1962), difference in central and peripheral projections (Preto Parvis, 1954), different sensory functions (Noden, 1980;Spassova, 1982), different histogenetic characteristics (Meyer et al, 1973), difference in distribution of cytoplasmic organelles and relative density of cytoplasm (Carmel and Stein, 1969;Matsuura et al, 1969), fluid shift between cells and the surrounding extracellular spaces (Moses, 1967), difference in functional activity have been offered as different hypotheses. Kalina and Wolman (1970), Peach (1972) and Silbermann and Finkelbrand (1978) found differences in chemical constituents in these two types of neurons in sensory ganglia of rodents. Similar observations have been reported in mammals (Cauna and Naik, 1963;Kalina and Bubis, 1969;Peach, 1972;Kishida et al, 1982).…”

Section: Introductionmentioning

confidence: 92%

Cellular Death as a Regulative Mechanism in the Control of Cell-Number towards Normal Establishment of Orderly Structure and Function in the Petrous Ganglion during Development and Aging: An Investigation in the Chick

.¹

2000

Pakistan J. of Biological Sciences

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On the evidence available from the present study in the Petrous ganglion, the dark cells are considered as active ones and the light cells are considered as resting, inactive, dying or degenerating cells. Cell death is most prominent and common among the small and medium sized ones. Probably, it is during these developmental stages, peripheral and central processes (of axons) begin to grow from the cell body and get established in their projection fields. The tiny cells are always dark. The very-small cells are also usually dark during embryonic development till E18. The light cells have appeared among this cell group just on the day of hatching. During the late stages of development (around E15-E18). the phagocytosis is too fast that the inactive, dying or dead cells (I. e., so-called light cells) are removed immediately as soon as they are formed so as not to leave such a light-cell stage for clear observation. The light-cell stage becomes clearly observable only when the phagocytic process is slow, and this becomes prominent at a time when some of the important connections are being actively established. The fluctuation in the number of cells during embryonic development may be considered as a normal process for the purpose of rearrangement and better organization to perform an orderly function most efficiently. The period of accelerated degeneration or loss of cells is the period of active establishment of proper connections of ganglion cells. The reduction or loss in the number of neurons in the adult ganglion might indicate a functional reduction probably as a result of aging process.

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Section: Introductionmentioning

confidence: 92%

Cellular Death as a Regulative Mechanism in the Control of Cell-Number towards Normal Establishment of Orderly Structure and Function in the Petrous Ganglion during Development and Aging: An Investigation in the Chick

.¹

2000

Pakistan J. of Biological Sciences

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“…Studies in the chick and rat (Gaik and Farbman 1973;Peach, 1972) concluded that these two types are genuinely different from each other in terms of density and distribution of cytoplasmic organelles. Differences in chemical constituents in these two types of neurones in the trigeminal ganglion have been reported (Kalina and Bubis, 1969;Silbermann and Finkelbrand, 1978). The significance of these two populations of neurones has been the subject of considerable speculations.…”

Section: Introductionmentioning

confidence: 99%

Cell Turnover in the Trigeminal Ganglion During Gangliogenesis and Aging Process and its Significance

.¹

2000

Pakistan J. of Biological Sciences

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A chronological, quantitative light microscopic investigation on the histogenic organisation and behaviour of the trigeminal-ganglion was carried out in the ontogeny of the chick. Embryos of 24 chicks at embryonic days 6-18 (E6-E18), on the day of hatching (H) and adult (A) were processed. Paraffin sections of 8 to 10 microns thick were stained with cresyl-fast-violet. Dark and light cells of various size-categories were observed. There were two periods of active proliferation: one on Embryonic Day 8 (E8) and another on E18. An active reduction in the total number of cells occurred during E10-E13 and during post-hatching period. Few light-cells started to appear on E8, continued to increase in number to reach its highest peak on, E13, while the number of dark cells have declined. There was a further fluctuation in the relative numbers of the dark and light cells during the period between E15-E18. The day of hatching marked a second peak of light cells and decline of dark cells. There was a tendency of increased proliferative activity, growth, and maturation of neurones as from E18 with the appearance of larger cell types. The periods of accelerated degeneration of ganglion cells may correspond to the period of active establishment of functional connections. Cell-death might have occurred due either to a failure of these projection-fibres to reach the target-fields or to a failure of making a functional connection. The reduction in the number of light-cells might be associated with the removal of thesd cells due to the increased phagocytic activity. On the basis of the fluctuation in the number of dark and light cells, it is assumed that the dark-cells represent a group of active cells while light-cells are either resting, inactive or dying cells. This assumption need to be confirmed by physiological and immunocytochemical studies.

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Somatotopic and functional organization of the avian trigeminal ganglion: An HRP analysis in the hatchling chick

Noden

1980

J of Comparative Neurology

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While the somatotopic organization of many central systems is well characterized, that of peripheral sensory neurons has not been adequately defined. This is especially true for the trigeminal ganglion. By applying HRP subcutaneously at each of 14 sites and also intramuscularly, it is possible to determine whether the location of sensory neurons within the ganglion reflects their peripheral projections. There is no discernible somatotopic organization of neurons in the ophthalmic lobe. However, the location of maxillary neurons in the maxillo-mandibular lobe is organized with the most posterior cells projecting to sites closest to the ganglion and with neurons located more anteriorly projecting to progressively more distant sites. There is a less well defined organization in the superior-inferior axis of the ganglion, and none along its proximal (root) to distal axis. Mandibular exteroceptive neurons are found primarily in the anterior region of the maxillo-mandibular lobe, while mandibular proprioceptive cells are located in the proximo-central part of this lobe. In most cases there is a considerable scattering of horseradish peroxidase (HRP)-filled neurons. Projections to contralateral ganglia, the trigeminal motor nucleus, and the trigeminal mesencephalic nucleus were also examined. Cytologically, the hatchling trigeminal consists of two interspersed types of neurons: large, lightly staining and smaller, darkly staining cells. Previous experiments have proved that these two cell types do not correspond to each of the embryonic precursors of trigeminal neurons, the neural crest and placodal cells. In this study HRP was found localized in both classes of neurons following injection at all sites, including jaw-closing muscles. This indicates that the dual cytology is not correlated with either distribution of peripheral fibers or exteroceptive vs. proprioceptive functions. The possibilities that the two types of neurons may have different central projections and/or may be related to visceral vs. somatic afferent functions are discussed.

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Activity of phosphatases and succinic dehydrogenase in the trigeminal ganglion of the corticosteroid-treated mouse

Cited by 5 publications

References 6 publications

Cellular Death as a Regulative Mechanism in the Control of Cell-Number towards Normal Establishment of Orderly Structure and Function in the Petrous Ganglion during Development and Aging: An Investigation in the Chick

Cellular Death as a Regulative Mechanism in the Control of Cell-Number towards Normal Establishment of Orderly Structure and Function in the Petrous Ganglion during Development and Aging: An Investigation in the Chick

Cell Turnover in the Trigeminal Ganglion During Gangliogenesis and Aging Process and its Significance

Somatotopic and functional organization of the avian trigeminal ganglion: An HRP analysis in the hatchling chick

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