Activity of phytochemical constituents of black pepper, ginger, and garlic against coronavirus (COVID-19): An in silico approach

Rajagopal, Kalirajan; Byran, Gowramma; Jupudi, Srikanth; Ramachandran, Vadivelan

doi:10.4103/ijhas.ijhas_55_20

Cited by 55 publications

(22 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study’s most cited medicinal plants for treating COVID-19, including some major phytochemical components of these plants, have been reported to display antiviral and immunomodulatory activities, summarized in Table 5 . For example, in an in silico docking study, Rajagopal et al [ 50 ] reported that 8-gingerol and 10-gingerol isolated from Z. officinale were active against COVID-19 with significantly higher Glide scores when compared to hydroxychloroquine. Curcumin, a bioactive compound from C. longa , has been reported to exhibit antiviral activity against different types of enveloped viruses via several mechanisms such as induction of host antiviral responses, direct interaction with viral membrane proteins, and disruption of the viral envelope [ 13 ].…”

Section: Resultsmentioning

confidence: 99%

Ethnobotanical Survey of Medicinal Plants Used in the Treatment of COVID-19 and Related Respiratory Infections in Ogbomosho South and North Local Government Areas, Oyo State, Nigeria

Odebunmi

Olatunji

Adetunji

et al. 2022

Plants

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) has extensively spread worldwide with high mortality. Besides vaccination, the United States Food and Drug Administration approved only one oral medication as a treatment. Medicinal plants with antiviral and immunomodulatory properties could be explored as complementary treatments for COVID-19. Ogbomosho is home to such plants traditionally used to treat infectious diseases in Nigeria, making it relevant in complementary medicine. An ethnobotanical survey of medicinal plants used to treat COVID-19 and related ailments, including cough and flu in Ogbomosho South and North Local Government Areas, Nigeria, was conducted using a semi-structured questionnaire. Information was obtained from 56 participants, consisting of different groups of individuals with native knowledge of medicinal plants, and ethnobotanical indices, including the frequency of citation (FC), relative frequency of citation (RFC), and fidelity level (FL) were computed. Twenty-six medicinal plants (17 families) were used to treat COVID-19, 31 (20 families) for cough, and 29 (19 families) for flu. The most cited plant was Zingiber officinale (FC = 10; RFC = 0.18; FL = 18%) for treating COVID-19, Citrus limon (FC = 13; RFC = 0.23; FL = 23%) for cough, and Zingiber officinale (FC = 9; RFC = 0.16; FL = 16%) for flu. Leaves were the most used plant part for treating COVID-19 and flu, while the bark was the most used for cough. Trees and herbs were the most cited plant growth forms. The herbal remedies were mostly prepared by decoction and infusion and were mainly administered orally. Further research should be conducted on the identified species for the scientific validation of their antiviral and immunomodulatory efficacies and safety for use.

show abstract

Section: Resultsmentioning

confidence: 99%

Ethnobotanical Survey of Medicinal Plants Used in the Treatment of COVID-19 and Related Respiratory Infections in Ogbomosho South and North Local Government Areas, Oyo State, Nigeria

Odebunmi

Olatunji

Adetunji

et al. 2022

Plants

View full text Add to dashboard Cite

show abstract

“…In the present study, we have chosen five Indian spice-yielding plants: Zingiber officinale Roscoe (ginger), Cuminum cyminum L. (cumin), Piper nigrum L. (black pepper), Curcuma longa L. (turmeric), and Allium sativum L. (garlic) as their broad-spectrum therapeutic properties are experimentally proved and well documented in various literature [ 29 ]. From these plants, a total of 200 phytocompounds ( 30 for Zingiber officinale Roscoe; 41 for Cuminum cyminum L.; 41 for Piper nigrum L.; 42 for Curcuma longa L., and 46 for Allium sativum L.) were screened against various breast cancer protein targets (i.e., CDK8, PR and EFGR).…”

Section: Introductionmentioning

confidence: 99%

Natural Phytocompounds from Common Indian Spices for Identification of Three Potential Inhibitors of Breast Cancer: A Molecular Modelling Approach

2022

View full text Add to dashboard Cite

Breast cancer is the second most common cancer-related cause of death for women throughout the globe. In spite of some effective measures, the main concerns with traditional anti-cancer chemotherapy are its low bioavailability, physical side effects, acquired resistance of cancer cells and non-specific targeting. Now researchers have taken the initiative to establish natural product-based therapy methods and to identify viable hits for future lead optimization in the development of breast cancer medication. Our study aims to identify the potent phytocompounds from five very popular Indian spices (Zingiber officinale Roscoe, Cuminum cyminum L., Piper nigrum L., Curcuma longa L., and Allium sativum L.). From these spices, a total of 200 phytocompounds were identified and screened against three target genes, namely, cyclin-dependent kinase 8 (CDK 8), progesterone receptor (PR) and epidermal growth factor receptor (EGFR), through structure-based virtual screening using iGEMDOCK 2.1 software. Based on the binding affinity score, the top three phytocompounds against each target protein (cynaroside (−149.66 Kcal/mol), apigetrin (−139.527 Kcal/mol) and curcumin (−138.149 Kcal/mol) against CDK8; apigetrin (−123.298 Kcal/mol), cynaroside (−118.635 Kcal/mol) and xyloglucan (−113.788 Kcal/mol) against PR; cynaroside (−119.18 Kcal/mol), apigetrin (−105.185 Kcal/mol) and xyloglucan (−105.106 Kcal/mol) against EGFR) were selected. Apigetrin, cynaroside, curcumin, and xyloglucan were finally identified for further docking analysis with the respective three target proteins. Autodock 4.2 was applied to screen the optimal binding position and to assess the relative intensity of binding interactions. In addition, the ADME/T property checks and bioactivity scores analysis of were performed to understand the suitability of these four phytocompounds to be potential candidates for developing effective and non-toxic anticancer agents. Based on this in silico analysis, we believe this study could contribute to current efforts to develop new drugs for treating breast cancer.

show abstract

“…The training intervention appeared to be effective in decreasing the influence of such conspiracy myths among the sanitary staff workers. The home remedies myths to treat coronavirus including use of garlic, ginger, honey, and herb tea [47,48] were also effectively addressed by the intervention. Though studies showed the nutritional effects of these diets [49], yet no empirical data support the therapeutic impact of such home remedies [50].…”

Section: Discussionmentioning

confidence: 99%

Myths and misconception of COVID-19 among hospital sanitary workers in Pakistan: Efficacy of a training program intervention

Malik

Musharraf

Safdar

et al. 2022

BMC Health Serv Res

View full text Add to dashboard Cite

Objective Hospital sanitary workers are among the prime source to disseminate information at a massive level, however they received least attention during the pandemic COVID-19. The study was designed to investigate the prevailing myths and misconceptions of the coronavirus pandemic among the sanitary workers of health care system. Further, a systematic training program is devised and tested to demystify the false myths with discerning truth and awareness-raising in hospital sanitary workers. Method A pre-post face-to-face intervention design was opted and the intervention was conducted at five locations by the project team. The intervention consisted a 3 days training program to target myths and misconceptions of hospital sanitary workers. The study was completed in 8 months starting from August, 2019 to March, 2020. Participants were recruited from local hospitals having a specialized indoor COVID treatment facility. The sample consisted of 82 participants (n = 25, 30.09% females) with age ranging from 18 to 60 years (M ± SD = 37.41 ± 10.09). Findings The results indicated that 86.4% of the participants never heard the name of the coronavirus before the pandemic in Pakistan. A majority of the participants (> 50%) believed on a very alarming but unrealistic rate of mortality i.e., 30–60%. The pre-testing showed a high prevalence of myths in all four domains (i.e., popular treatments = 24.44, conspiracy myths = 7.93, home remedies = 16.46, and COVID-reliance = 7.82). The pre and post comparison of individual myths showed significant improvement on 24 of the 26 myths with a decline ranging from 0.18 to 1.63. Overall, the intervention significantly decreased scores on all four domains of coronavirus myths. Conclusion The training intervention appeared to effectively reduce myths and misconceptions of sanitary staff workers and is advised to be included as a standard training program for sanitary workers of health care system.

show abstract

Activity of phytochemical constituents of black pepper, ginger, and garlic against coronavirus (COVID-19): An in silico approach

Cited by 55 publications

References 33 publications

Ethnobotanical Survey of Medicinal Plants Used in the Treatment of COVID-19 and Related Respiratory Infections in Ogbomosho South and North Local Government Areas, Oyo State, Nigeria

Ethnobotanical Survey of Medicinal Plants Used in the Treatment of COVID-19 and Related Respiratory Infections in Ogbomosho South and North Local Government Areas, Oyo State, Nigeria

Natural Phytocompounds from Common Indian Spices for Identification of Three Potential Inhibitors of Breast Cancer: A Molecular Modelling Approach

Myths and misconception of COVID-19 among hospital sanitary workers in Pakistan: Efficacy of a training program intervention

Contact Info

Product

Resources

About