“…Variations of serum lipoproteins in normal subjects and in various diseases (385), as a function of age (490), and as a result of senescence (424) have been studied; a double beta-lipoprotein has been reported to be a normal genetic variant in humans (2018). There are studies of the effects upon lipoproteins of vitamin D (1630), chorionic gonadotropin (1008), prednisone (456), and heparin (822); serum lipoproteins also are affected by many diseases, including coronary disease (2436), arteriosclerosis (54,1887,1919,2368), cerebral hypertension (1395), cancer (1061,1362,1604), placental insufficiency (1901), skin reticulosis (2216), multiple sclerosis (734), hepatitis (1401), syphilis (1356), rheumatism (1923), lymphogranulomatosis (1060), and chronic enterocolitis (330). Lipoprotein distribution in the serum of normal and hypercholesterolemic dogs, rats, and guinea pigs (831) and vitamin C-deprived guinea pigs (472), and in the brains of guinea pigs (1502) has been studied.…”