Activity of the Hypothalamic-Pituitary-Adrenal Axis is Elevated in Rats with Activity-Based Anorexia

Vr, Burden; Bd, White; Rg, Dean; Rj, Martin

doi:10.1093/jn/123.7.1217

Cited by 71 publications

(53 citation statements)

References 23 publications

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“…It has been reported that olanzapine treatment enhances ingestive behavior in food-deprived rats (Thornton-Jones et al 2002); however, it is possible that the 1-hour feeding period in our experiment was too short to observe an orexigenic effect of olanzapine. As a result of restricted feeding and wheel running, the HPA axis is considerably activated in ABA rats (Burden et al 1993). In our study, it was shown that olanzapine treatment decreased ACTH levels and tended to decrease corticosterone levels and adrenal weight in ABA rats, thereby reducing stress levels in ABA rats.…”

Section: Discussionsupporting

confidence: 47%

Olanzapine Reduces Physical Activity in Rats Exposed to Activity-Based Anorexia: Possible Implications for Treatment of Anorexia Nervosa?

Hillebrand

Elburg

Kas

et al. 2005

Biological Psychiatry

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Section: Discussionsupporting

confidence: 47%

Olanzapine Reduces Physical Activity in Rats Exposed to Activity-Based Anorexia: Possible Implications for Treatment of Anorexia Nervosa?

Hillebrand

Elburg

Kas

et al. 2005

Biological Psychiatry

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“…Previous studies reported that the effects of resocialization, like decreased food intake and body weight, were attributed to various factors like housing changeinduced temporary stress, 12 mutual hindrance in feeding, 11 increased bodily activity and energy expenditure. 53,54 We, therefore, suggest that, re-socialization might reverse the effects of isolation including the chronic psychological stress. The effects of re-socialization were also reflected in the CART immunohistochemistry profile.…”

Section: Discussionmentioning

confidence: 90%

Central regulation of feeding behavior during social isolation of rat: evidence for the role of endogenous CART system

et al. 2010

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Objective: Although hyperphagia and body weight gain are well-recognized consequences of social isolation, the underlying mechanisms are not understood. The aim of this work is to test the possibility that the endogenous cocaine-and amphetamineregulated transcript peptide (CART) may be involved in the process. Design: Socially isolated rats were screened for increase in food intake and body weight, and the modifications of these parameters by CART were evaluated. Furthermore, isolated animals were re-socialized and screened for reversal of these effects. Response of the endogenous CART system, in certain hypothalamic nuclei of the isolated and re-socialized rats, was evaluated with immunohistochemistry. Subjects: Fifty days old naive male Sprague-Dawley rats were used. Measurements: The effects of CART/CART antibody on the social isolation and subsequent re-socialization on feeding and body weight changes were monitored. Moreover, the immunohistochemical response of endogenous CART system to social isolation and re-socialization was analyzed morphometrically. Results: While social isolation of rats for a period of 6 weeks caused progressive increase in food consumption and body weight gain, these rats showed a significant reduction in food intake and body weight when injected daily with CART via intracerebroventricular (i.c.v.) route, for the following 7 days. The re-socialization of isolated rats reduced food intake and body weight to the control levels. These effects of re-socialization were attenuated by immunoneutralization of the endogenous CART by i.c.v. CART antibody. Social isolation also resulted in a drastic reduction in CART immunoreactivity in the cells and/or fibers in the hypothalamic areas like dorsomedial, ventromedial, lateral, paraventricular and arcuate nuclei, recognized for their role in feeding. On the other hand, the CART immunoreactivity profile was fully restored following 7 days of re-socialization of the isolation-reared rats. Conclusion: Social isolation might down-regulate the hypothalamic CART-containing system, which in turn may lead to increase in food intake and body weight.

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“…Enhanced RWA is specifically observed a few hours prior to food access, a phenomenon, which is described as food-anticipatory activity (FAA) (Mistlberger, 1994). Additionally, rats decrease food intake, lose body weight as well as body temperature and the hypothalamus-pituitary-adrenal (HPA) axis is activated (Burden et al, 1993;Hall and Hanford, 1954;Hillebrand et al, 2005a;Routtenberg and Kuznesof, 1967).…”

Section: Introductionmentioning

confidence: 99%

AgRP(83–132) and SHU9119 differently affect activity-based anorexia

Hillebrand

Kas

Scheurink

et al. 2006

European Neuropsychopharmacology

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Activity-based anorexia (ABA) mimics starvation and hyperactivity of anorexia nervosa patients in rats. Activation of the melanocortin (MC) system leads to hypophagia and increased energy expenditure in ad libitum fed rats. Therefore, activation of the MC system might underlie the development and propagation of ABA. Pro-opiomelanocortin (POMC) gene expression is normally decreased during negative energy balance. Strikingly, we found a transient up-regulation of POMC mRNA levels in the arcuate nucleus during the development of ABA, indicating a hyperactive MC system. However, wheel running and food intake were not influenced by treating ABA rats with the competitive antagonist SHU9119. This suggests that agonism of MC receptors by endogenous a-melanocyte-stimulating hormone (a-MSH) levels does not underlie ABA. Instead, treatment with the inverse agonist AgRP did ameliorate signs of ABA. This implies that modulation of constitutive MC receptor activity rather than antagonizing putative a-MSH release contributes to the development and propagation of ABA.

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Activity of the Hypothalamic-Pituitary-Adrenal Axis is Elevated in Rats with Activity-Based Anorexia

Cited by 71 publications

References 23 publications

Olanzapine Reduces Physical Activity in Rats Exposed to Activity-Based Anorexia: Possible Implications for Treatment of Anorexia Nervosa?

Olanzapine Reduces Physical Activity in Rats Exposed to Activity-Based Anorexia: Possible Implications for Treatment of Anorexia Nervosa?

Central regulation of feeding behavior during social isolation of rat: evidence for the role of endogenous CART system

AgRP(83–132) and SHU9119 differently affect activity-based anorexia

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