Activity of the Serotonergic System During Isoflurane Anesthesia

Mukaida, Kumiko; Shichino, Tsutomu; Koyanagi, Sahoko; Himukashi, Shugaku; Fukuda, Kazuhiko

doi:10.1213/01.ane.0000255200.42574.22

Cited by 47 publications

(43 citation statements)

References 21 publications

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“…In agreement with our hypothesis, we observed that icv administration of YM-31636 attenuates the hypnotic effects of emulsified sevoflurane. This is also in agreement with the findings of Mukaida et al [16]. In this study, serotonergic activity modulated the hypnotic effects of isoflurane.…”

Section: Discussionsupporting

confidence: 94%

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Involvement of 5-hydroxytryptamine type 3 receptors in sevoflurane-induced hypnotic and analgesic effects in mice

Hang

Shao

Wang

et al. 2010

Pharmacological Reports

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Abstract:In the present study, we investigated the role of 5-hydroxytryptamine type 3 (5-HT 3 ) receptors in hypnosis and analgesia induced by emulsified sevoflurane. A mouse model of hypnosis and analgesia was established by an intraperitoneal or subcutaneous injection of emulsified sevoflurane. We intracerebroventricularly (icv) or intrathecally (it) administered YM-31636, a 5-HT 3 receptor agonist, to mice and observed sleep time during hypnosis. In addition, the tail withdrawal latency was measured using the tail withdrawal test, and the writhing time was determined using the acetic acid writhing test. In the hypnosis test, YM-31636 (5, 10 and 15 µg, icv) treatment significantly decreased emulsified sevoflurane-induced mouse sleep time (p < 0.05 or p < 0.01). YM-31636 (2.5, 5 and 10 µg, it) treatment significantly and dose-dependently decreased the tail withdrawal latency (p < 0.05 or p < 0.01) and increased the writhing time (p < 0.01) of mice treated with emulsified sevoflurane. These results suggest that 5-HT 3 receptors may modulate the hypnotic and analgesic effects induced by emulsified sevoflurane.

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Section: Discussionsupporting

confidence: 94%

“…Sevoflurane is a halogenated inhalation anesthetic. In vitro electrophysiological studies have demonstrated that sevoflurane inhibits 5-HT 3 receptors [16,28]. Therefore, 5-HT 3 receptors may confer sevoflurane-dependent anesthesia.…”

Section: Introductionmentioning

confidence: 99%

Involvement of 5-hydroxytryptamine type 3 receptors in sevoflurane-induced hypnotic and analgesic effects in mice

Hang

Shao

Wang

et al. 2010

Pharmacological Reports

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“…Different studies have also pointed out an effect of volatile anesthetics (e.g., isoflurane) on the serotonergic system (39,40). Mukaida et al described a decreased frontocortical release of the neurotransmitter serotonin in rats during isoflurane administration (39). However, we removed these interactions between anesthetics and radioligand binding by adhering strictly to the same anesthetic protocol in both groups.…”

Section: Methodologic Considerationsmentioning

confidence: 98%

“…However, the interval between sedation and scanning was less than 10 min, a time during which occurrence of these effects may be considered negligible, albeit not impossible. Different studies have also pointed out an effect of volatile anesthetics (e.g., isoflurane) on the serotonergic system (39,40). Mukaida et al described a decreased frontocortical release of the neurotransmitter serotonin in rats during isoflurane administration (39).…”

Section: Methodologic Considerationsmentioning

confidence: 99%

Evaluation of the Brain 5-HT2A Receptor Binding Index in Dogs with Anxiety Disorders, Measured with ¹²³I-5I-R91150 and SPECT

Vermeire¹,

Audenaert²,

Dobbeleir³

et al. 2009

J Nucl Med

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The serotonergic system has been implicated in emotional and cognitive functions since early work. In particular, an important role has been attributed to the 5-HT2A receptor in schizophrenia, depression, eating disorders, and anxiety. The aim of the study was to evaluate the involvement of the brain 5-HT2A receptor in dogs with severe anxiety disorder, using 123 I-5I-R91150 and SPECT. Methods: SPECT was performed with the 5-HT2A receptor-specific radioligand 123 I-5I-R91150 to determine the 5-HT2A receptor binding index (BI) in the brains of dogs. Sixteen dogs with pathologic anxiety problems were compared with 22 normal-behaving reference dogs. Results: Lower 5-HT2A receptor BI was found in the left (P 5 0.001) and right (P 5 0.002) frontal cortices in the group of dogs with anxiety disorders than in the reference group. Right (P 5 0.022) and left (P 5 0.048) temporocortical BIs were also significantly lower in the dogs with anxiety disorders. Finally, the BI was significantly lower in the right occipital cortex (P 5 0.038) of dogs with anxiety disorders than in the reference dogs. After correction for multiple comparisons (P , 0.0056), only the bilateral frontocortical lower BI remained significant. Conclusion: The findings in this study indicate that the 5-HT2A receptor is involved in the pathophysiology of anxiety disorders in dogs. The affected brain regions are in concordance with the brain regions involved in human anxiety disorders. The acquired data confirm the potential of using the dog as a natural model for investigation of the different mechanisms of anxiety disorders. In this regard, the use of dogs may contribute to the development of novel treatment approaches and new drugs for veterinary and human use.

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“…A tracer can be delivered either as two bolus injections, i.e., control and challenge (Logan et al, 1991) or as a single bolus plus infusion (Endres et al, 1997). In general, the bolus plus infusion approach has the advantage that the challenge can be introduced at equilibrium, its effect on neurotransmitter release is Measuring endogenous 5-HT release by emission tomography LM Paterson et al (Mukaida et al, 2007;Seeman and Kapur, 2003;Tokugawa et al, 2007) Possible confound. Complicates extrapolation to humans and between experimental designs and species Systematic studies required to optimise anaesthetic and discount confounds (Elfving et al, 2003) Nature of challenge Multisite pharmacology…”

Section: Pet Protocol Designmentioning

confidence: 99%

Measuring Endogenous 5-HT Release by Emission Tomography: Promises and Pitfalls

Paterson

Tyacke

Nutt

et al. 2010

J Cereb Blood Flow Metab

128

137

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Molecular in vivo neuroimaging techniques can be used to measure regional changes in endogenous neurotransmitters, evoked by challenges that alter synaptic neurotransmitter concentration. This technique has most successfully been applied to the study of endogenous dopamine release using positron emission tomography, but has not yet been adequately extended to other neurotransmitter systems. This review focuses on how the technique has been applied to the study of the 5-hydroxytryptamine (5-HT) system. The principles behind visualising fluctuations in neurotransmitters are introduced, with reference to the dopaminergic system. Studies that aim to image acute, endogenous 5-HT release or depletion at 5-HT receptor targets are summarised, with particular attention to studies in humans. Radiotracers targeting the 5-HT 1A , 5-HT 2A , and 5-HT 4 receptors and the serotonin reuptake transporter have been explored for their sensitivity to 5-HT fluctuations, but with mixed outcomes; tracers for these targets cannot reliably image endogenous 5-HT in humans. Shortcomings in our basic knowledge of the mechanisms underlying changes in binding potential are addressed, and suggestions are made as to how the selection of targets, radiotracers, challenge paradigms, and experimental design might be optimised to improve our chances of successfully imaging endogenous neurotransmitters in the future.

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Activity of the Serotonergic System During Isoflurane Anesthesia

Abstract: It is suggested that a change in the activity of the serotonergic system in the brain is involved in the hypnotic action of isoflurane.

Cited by 47 publications

References 21 publications

Involvement of 5-hydroxytryptamine type 3 receptors in sevoflurane-induced hypnotic and analgesic effects in mice

Involvement of 5-hydroxytryptamine type 3 receptors in sevoflurane-induced hypnotic and analgesic effects in mice

Evaluation of the Brain 5-HT2A Receptor Binding Index in Dogs with Anxiety Disorders, Measured with ¹²³I-5I-R91150 and SPECT

Measuring Endogenous 5-HT Release by Emission Tomography: Promises and Pitfalls

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Activity of the Serotonergic System During Isoflurane Anesthesia

Abstract: It is suggested that a change in the activity of the serotonergic system in the brain is involved in the hypnotic action of isoflurane.

Cited by 47 publications

References 21 publications

Involvement of 5-hydroxytryptamine type 3 receptors in sevoflurane-induced hypnotic and analgesic effects in mice

Involvement of 5-hydroxytryptamine type 3 receptors in sevoflurane-induced hypnotic and analgesic effects in mice

Evaluation of the Brain 5-HT2A Receptor Binding Index in Dogs with Anxiety Disorders, Measured with 123I-5I-R91150 and SPECT

Measuring Endogenous 5-HT Release by Emission Tomography: Promises and Pitfalls

Contact Info

Product

Resources

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Evaluation of the Brain 5-HT2A Receptor Binding Index in Dogs with Anxiety Disorders, Measured with ¹²³I-5I-R91150 and SPECT