Activity of Three 8-Hydroxyquinoline Derivatives Against In Vitro Dental Plaque

Abstract

Three 8-hydroxyquinoline derivatives, assessed using an in vitro preformed dental plaque model system, were differentially inhibitory for four plaque-forming microorganisms.

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

“…Antimicrobial effects of 8HQ and its derivatives encompassing antibacterial,102–104 antimalarial,105–107 antiviral,108 antitubercular,109 and antidental plaque activities110,111 have been previously reported.…”

“…The result showed that all 8HQ derivatives differentially inhibited each of the tested organisms 111. These compounds were prepared in percentage concentrations in polyethylene glycol owing to their sparingly water-soluble nature 111. CQ and 5,7-dichloro-8HQ exerted a bactericidal effect at 0.05% concentration on S. mutans (cariogenic) and A. viscosus (periodontogenic), whereas 8HQ sulfate showed a bacteriostatic effect against both pathogens at a higher (0.3%) concentration 111.…”

“…Antidental plaque activity of 8HQ derivatives has been reported 110,111. Dental plaque is a combination of oral microorganisms colonized on oral surfaces in which a microbial consortium or oral biofilm is formed 115.…”

“…An in vitro study of antidental plaque activity of three 8HQ derivatives, namely 8HQ sulfate, 5-chloro-7-iodo-8HQ (or CQ), and 5,7-dichloro-8HQ, against S. mutans, Streptococcus sanguis, Actinomyces viscosus , and Actinomyces naeslundii was reported. The result showed that all 8HQ derivatives differentially inhibited each of the tested organisms 111. These compounds were prepared in percentage concentrations in polyethylene glycol owing to their sparingly water-soluble nature 111.…”

“…These compounds were prepared in percentage concentrations in polyethylene glycol owing to their sparingly water-soluble nature 111. CQ and 5,7-dichloro-8HQ exerted a bactericidal effect at 0.05% concentration on S. mutans (cariogenic) and A. viscosus (periodontogenic), whereas 8HQ sulfate showed a bacteriostatic effect against both pathogens at a higher (0.3%) concentration 111. It was demonstrated that halogenated 8HQs were more potent dental plaque inhibitors 110,111.…”