2006
DOI: 10.1083/jcb.200507119
|View full text |Cite
|
Sign up to set email alerts
|

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

Abstract: Loss of tuberin, the product of TSC2 gene, increases mammalian target of rapamycin (mTOR) signaling, promoting cell growth and tumor development. However, in cells expressing tuberin, it is not known how repression of mTOR signaling is relieved to activate this pathway in response to growth factors and how hamartin participates in this process. We show that hamartin colocalizes with hypophosphorylated tuberin at the membrane, where tuberin exerts its GTPase-activating protein (GAP) activity to repress Rheb sig… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

9
294
1
2

Year Published

2006
2006
2021
2021

Publication Types

Select...
8
2

Relationship

1
9

Authors

Journals

citations
Cited by 308 publications
(310 citation statements)
references
References 46 publications
9
294
1
2
Order By: Relevance
“…All TSC2 mutants were observed to form a distinct, punctuate pattern in the absence of serum, as previously observed, 22 and we did not detect any substantial difference in localization of these TSC2 mutants when compared with wild type (Supplementary Figure 1).…”
Section: Clinical Featuressupporting
confidence: 88%
“…All TSC2 mutants were observed to form a distinct, punctuate pattern in the absence of serum, as previously observed, 22 and we did not detect any substantial difference in localization of these TSC2 mutants when compared with wild type (Supplementary Figure 1).…”
Section: Clinical Featuressupporting
confidence: 88%
“…P < 0.001 (log-rank test). Although response to genotoxic stress is a nuclear function of ATM, TSC2 functions in the cytoplasm (32), raising the question as to the cellular compartment(s) for ATM signaling to TSC2 to repress mTORC1. The rapid repression of mTORC1 induced by H 2 O 2 was not observed with the DNA damaging agent etoposide (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…There are a number of possibilities for explaining the role of TSC1-NTD in TSC1 stability. It may have a role in TSC1 localization, in particular to the cell membrane 38 . In this regard, it is interesting to note that a transmembrane helix was previously predicted.…”
Section: Discussionmentioning
confidence: 99%