Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study

Abstract

Plasma XO activity correlates with indices of insulin resistance and liver dysfunction in Japanese patients with type 2 diabetes mellitus and MetS. Through assessing the plasma XO activity, patients showing normal levels of serum uric acid with higher activity of XO can be screened, thereby possibly providing a clue to uncovering metabolic risks in type 2 diabetes mellitus and MetS patients.

Annual change in plasma xanthine oxidoreductase activity is associated with changes in liver enzymes and body weight

“…Change in body weight may be indirectly associated with change in plasma XOR activity through modulation of hypoxanthine secretion from adipose tissue as a substrate of XOR. Other than liver dysfunction and obesity, plasma activity of XOR is associated with a habit of smoking and the presence of lifestyle-related diseases, including hyperuricemia, hypertension, dyslipidemia and diabetes mellitus [6][7][8][9]. However, in the present study, no significant difference was observed between annual changes in plasma XOR activities in participants with and those without a habit of smoking (Fig.…”

“…An accurate assay for plasma activity of XOR in humans has recently been established using triple quadrupole mass spectrometry and liquid chromatography to detect the formation of [ 13 C 2 , 15 [5]. Using this method, we and others have recently demonstrated that plasma XOR activity is a new biomarker of metabolic disorders associated with obesity, insulin resistance, liver dysfunction, hyperuricemia and adipokines [6][7][8][9]. In addition, it has been reported that habitual exercise can decrease plasma XOR activity [10].…”

A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly sensitive assay

“…To overcome this issue, in the present study, we measured XO activities using considerably high sensitive fluorometric assay, thereby precisely estimating the plasma XO activities in all samples studied. Our recent study demonstrated that the value of plasma XO activity is not affected by the time point, diet, or exercise . The IQR analyses in the present study further confirmed that plasma XO activity was stable in each individual as far as levels of liver transaminases were constant.…”

“…Our recent study demonstrated that the value of plasma XO activity is not affected by the time point, diet, or exercise. 10 The IQR analyses in the present study further confirmed that plasma XO activity was stable in each individual as far as levels of liver F I G U R E 1 (A), Serial measurements of clinical parameters in four cases with allogeneic hematopoietic stem cell transplantation. After the engraftment, all patients showed skin symptoms and intestinal symptoms as graft-versus-host diseases (GVHD).…”

Obesity, metabolic syndrome and bariatric surgery: A narrative review

“…Elevated circulating member B levels of the family with sequence similarity 3 might be a predictor of MetS onset and progression 5 . Plasma xanthine oxidase activity was correlated with indices of insulin resistance and liver dysfunction in Japanese patients with type 2 diabetes and MetS 6 . Table 1 shows the summary results for predictors and markers of obesity and MetS.…”