“…Gabapentin and pregabalin are effective in several models of anticonvulsant action (Welty et al, 1993;Vartanian et al, 2006). By contrast, pregabalin did not reduce the incidence of spontaneous absence seizures in a genetic rat model of absence seizures (Vartanian et al, 2006). The effect of these drugs in several epilepsy models has been shown to result from binding to a 2 d-1, rather than a 2 d-2 (Lotarski et al, 2014), although there was no widespread upregulation of brain a 2 d-1 in two epilepsy models studied (Nieto-Rostro et al, 2014).…”