Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma

Zhang, Xinwen; Huck, Kurt; Jähne, Kristine; Cichon, Frederik; Sonner, Jana K.; Ufer, Friederike; Bauer, Simone; Woo, Marcel S; Green, Ed; Lu, Kevin; Kilian, Michael; Friese, Manuel A.; Platten, Michael; Sahm, Katharina

doi:10.1080/2162402x.2021.1920739

Cited by 4 publications

(1 citation statement)

References 49 publications

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“…Cacnb3 deficiency resulted in an impaired ATPinduced migration, whereas baseline and LPS-mediated migration were not affected. This is particularly noteworthy as our previous findings showed impaired steady-state and LPS-induced migration in Arc-deficient BMDCs (7,39). The specific impairment of ATPdependent migration is consistent with studies that showed different migratory patterns between PAMP and DAMP exposure (40).…”

Section: Discussionsupporting

confidence: 90%

Calcium channel β3 subunit regulates ATP-dependent migration of dendritic cells

Woo,

Ufer,

Sonner

et al. 2023

Sci. Adv.

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Migratory dendritic cells (migDCs) continuously patrol tissues and are activated by injury and inflammation. Extracellular adenosine triphosphate (ATP) is released by damaged cells or actively secreted during inflammation and increases migDC motility. However, the underlying molecular mechanisms by which ATP accelerates migDC migration is not understood. Here, we show that migDCs can be distinguished from other DC subsets and immune cells by their expression of the voltage-gated calcium channel subunit β3 (Cavβ3; CACNB3), which exclusively facilitates ATP-dependent migration in vitro and during tissue damage in vivo. By contrast, CACNB3 does not regulate lipopolysaccharide-dependent migration. Mechanistically, CACNB3 regulates ATP-dependent inositol 1,4,5-trisphophate receptor–controlled calcium release from the endoplasmic reticulum. This, in turn, is required for ATP-mediated suppression of adhesion molecules, their detachment, and initiation of migDC migration. Thus, Cacnb3 -deficient migDCs have an impaired migration after ATP exposure. In summary, we identified CACNB3 as a master regulator of ATP-dependent migDC migration that controls tissue-specific immunological responses during injury and inflammation.

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Section: Discussionsupporting

confidence: 90%

Calcium channel β3 subunit regulates ATP-dependent migration of dendritic cells

Woo,

Ufer,

Sonner

et al. 2023

Sci. Adv.

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T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels

Messmer,

Thommek,

Piechutta

et al. 2024

Immunity

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mRNA Trafficking in the Nervous System: A Key Mechanism of the Involvement of Activity-Regulated Cytoskeleton-Associated Protein (Arc) in Synaptic Plasticity

et al. 2021

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Synaptic activity mediates information storage and memory consolidation in the brain and requires a fast de novo synthesis of mRNAs in the nucleus and proteins in synapses. Intracellular localization of a protein can be achieved by mRNA trafficking and localized translation. Activity-regulated cytoskeleton-associated protein (Arc) is a master regulator of synaptic plasticity and plays an important role in controlling large signaling networks implicated in learning, memory consolidation, and behavior. Transcription of the Arc gene may be induced by a short behavioral event, resulting in synaptic activation. Arc mRNA is exported into the cytoplasm and can be trafficked into the dendrite of an activated synapse where it is docked and translated. The structure of Arc is similar to the viral GAG (group-specific antigen) protein, and phylogenic analysis suggests that Arc may originate from the family of Ty3/Gypsy retrotransposons. Therefore, Arc might evolve through “domestication” of retroviruses. Arc can form a capsid-like structure that encapsulates a retrovirus-like sentence in the 3 ′ -UTR (untranslated region) of Arc mRNA. Such complex can be loaded into extracellular vesicles and transported to other neurons or muscle cells carrying not only genetic information but also regulatory signals within neuronal networks. Therefore, Arc mRNA inter- and intramolecular trafficking is essential for the modulation of synaptic activity required for memory consolidation and cognitive functions. Recent studies with single-molecule imaging in live neurons confirmed and extended the role of Arc mRNA trafficking in synaptic plasticity.

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Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma

Abstract: Sahm (2021) Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental

Cited by 4 publications

References 49 publications

Calcium channel β3 subunit regulates ATP-dependent migration of dendritic cells

Calcium channel β3 subunit regulates ATP-dependent migration of dendritic cells

T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels

mRNA Trafficking in the Nervous System: A Key Mechanism of the Involvement of Activity-Regulated Cytoskeleton-Associated Protein (Arc) in Synaptic Plasticity

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