Activity rhythm of golden hamster (<i>Mesocricetus auratus</i>) can be entrained to a 19-h light-dark cycle

Chiesa, Juan José; Anglès-Pujolràs, Montserrat; Dı́ez-Noguera, Antoni; Cambras, Trinitat

doi:10.1152/ajpregu.00139.2005

Cited by 10 publications

(12 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present estimate of the lower range of entrainment in wt animals is similar to those of Pittendrigh and Daan (1976b) and Carmichael et al (1981), although light intensity, photophase duration, and other aspects of the procedure may affect this value (Boulos et al, 2002;Chiesa et al, 2005 andGorman et al, 2005). The present estimate of the lower range of entrainment in wt animals is similar to those of Pittendrigh and Daan (1976b) and Carmichael et al (1981), although light intensity, photophase duration, and other aspects of the procedure may affect this value (Boulos et al, 2002;Chiesa et al, 2005 andGorman et al, 2005).…”

Section: Range Of Entrainmentsupporting

confidence: 57%

Effects of the Duper Mutation on Responses to Light

Bittman

2014

J Biol Rhythms

View full text Add to dashboard Cite

The duper mutation in Syrian hamsters shortens the free-running period (τDD) of locomotor activity by approximately 1 h when expressed on the wild-type background and by 2 h on the tau mutant background ("super duper"). In either case, duper markedly amplifies the phase response curve (PRC) of the light pulse. This work examined whether the duper mutation alters parametric as well as nonparametric properties, intensity thresholds, and noncircadian responses to light. Furthermore, it assessed the effects of duper on the range of entrainment and circadian aftereffects. In the first study, duper mutant and wild-type (wt) hamsters showed a similar intensity threshold for light-induced phase shifts. In the second, wt, tau mutant, and super duper hamsters were exposed to LD cycles whose period (T) progressively shortened. Regardless of whether the light phase was held at 50% of T or fixed at 3 h, super duper mutants entrained to a wider range of T cycles and showed aftereffects upon release into DD. In the third study, τLL was measured in mutant and wt hamsters that were maintained for 30-day intervals in constant light of progressively greater intensities. With increasing light intensity, the circadian period shortened in duper mutants. Circadian rhythms of super duper hamsters were disrupted at light intensities considerably below those that induced arrhythmicity in wt, tau heterozygote, or duper homozygote hamsters. In the fourth study, hamsters that were wt or homozygous for duper received two 15-min light pulses: the first at CT14 to CT16 or CT17 to CT19 and the second 2 h later. As expected, wt and duper mutants showed weak and strong resetting, respectively. Light pulses in early subjective night had an additive effect in mutant but not in wt hamsters, indicating that larger phase shifts of the pacemaker take longer to complete. Finally, super duper hamsters showed slightly but not significantly more negative masking than did wt or duper mutant hamsters. These results indicate that the duper mutation affects the properties of the central circadian pacemaker. The mutant allele affects not only the PRC but also parametric responses to light.

show abstract

Section: Range Of Entrainmentsupporting

confidence: 57%

Effects of the Duper Mutation on Responses to Light

Bittman

2014

J Biol Rhythms

View full text Add to dashboard Cite

show abstract

“…Finally, when various durations of light pulses were used, the maximum phase advance shown in C57 mice never exceeded 2 to 3 h (Schwartz and Zimmerman 1990; Comas et al 2006), leading to the prediction that 22 h would be the lower limit of the entrainment range. Combined, the summarized experiments conclude that entrainment to T18, which requires a daily decrease of nearly 6 h from the free-running period, even when animals are housed in apparent optimal conditions (i.e., singly housed with wheel; Cambras et al 2000; Chiesa et al 2005), is unprecedented.…”

Section: Discussionmentioning

confidence: 96%

“…This range of entrainment, however, can be markedly extended by exposure to dim light at night (compared with complete darkness) at an illuminance comparable to starlight or dim moonlight (Boulos et al 2002; Gorman et al 2005; Gorman et al 2006), even though such low light levels have been reported to be too weak to shift the clock (Brainard et al 1982; Brainard et al 1984; Nelson and Takahashi 1991a; Nelson and Takahashi 1991b; Brainard et al 2001). With the incorporation of dim nighttime illumination, hamsters were successfully entrained to T-cycles up to 30 h (Gorman et al 2005) or as low as 19 h (Chiesa et al 2005).…”

mentioning

confidence: 99%

Simple Lighting Manipulations Facilitate Behavioral Entrainment of Mice to 18-h Days

Walbeek

Gorman

2017

J Biol Rhythms

View full text Add to dashboard Cite

In an invariantly rhythmic world, a robust and stable mammalian circadian clock is presumed to confer fitness advantages. In shift-work or after rapid transmeridian travel, however, a stable clock might be maladaptive and a more flexibly resettable clock may have advantages. The rate at which rodents can adjust to simulated time zone travel and the range of entrainment can be markedly increased through simple light manipulations, namely, by exposing animals to extremely dim light (<0.01 lux) at night or by bifurcating rhythms under 24-h light-dark-light-dark (LDLD) cycles. Here we investigated the separate effects of dim light and bifurcation on the ability of mice to entrain to 18-h days (LD 13:5; T18). Incorporating dim light at night, mice in Experiment 1 were exposed either to LD cycles with photophases that were progressively shortened from LD 19:5 to LD 13:5 or to bifurcating LDLD cycles with photophases that were lengthened from LDLD 7:5:7:5 to LDLD 13:5:13:5. In both cases, wheel-running rhythms were robustly synchronized to T18 and the phase of the free-running circadian rhythm was controlled by the timing of release into constant conditions. In Experiment 2, either dimly illuminated nights or a history of bifurcation without continuing dim light was sufficient to allow behavioral entrainment to T18 whereas previously unbifurcated mice under dark nights failed to entrain to T18. Additionally, concurrent measurement of body temperature rhythms in T24 LDLD revealed them to be bimodal. These studies suggest that the circadian system is markedly more flexible than conventionally thought and that this flexibility can be achieved in a noninvasive and nonpharmacological way. Facilitation of behavioral entrainment to extreme light-dark cycles may have translational potential for human shift-workers.

show abstract

“…Wheel running has been shown to function as a feedback signal for the circadian clock, helping animals synchronize to shortened light–dark cycles (Chiesa et al. ). We found that volitional access to running wheel under ChrA, both prevented the forced desynchronization of locomotor activity rhythms and was accompanied by normal body weight gain, as compared to control animals under LD also allowed to access a running wheel.…”

Section: Discussionmentioning

confidence: 99%

Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice

et al. 2016

Self Cite

View full text Add to dashboard Cite

Metabolic functions are synchronized by the circadian clock setting daily patterns of food intake, nutrient delivery, and behavioral activity. Here, we study the impact of chronic jet‐lag (CJL) on metabolism, and test manipulations aimed to overcome potential alterations. We recorded weight gain in C57Bl/6 mice under chronic 6 h advances or delays of the light–dark cycle every 2 days (ChrA and ChrD, respectively). We have previously reported ChrA, but not ChrD, to induce forced desynchronization of locomotor activity rhythms in mice (Casiraghi et al. 2012). Body weight was rapidly increased under ChrA, with animals tripling the mean weight gain observed in controls by day 10, and doubling it by day 30 (6% vs. 2%, and 15% vs. 7%, respectively). Significant increases in retroperitoneal and epidydimal adipose tissue masses (172% and 61%, respectively), adipocytes size (28%), and circulating triglycerides (39%) were also detected. Daily patterns of food and water intake were abolished under ChrA. In contrast, ChrD had no effect on body weight. Wheel‐running, housing of animals in groups, and restriction of food availability to hours of darkness prevented abnormal increase in body weight under ChrA. Our findings suggest that the observed alterations under ChrA may arise either from a direct effect of circadian disruption on metabolism, from desynchronization between feeding and metabolic rhythms, or both. Direction of shifts, timing of feeding episodes, and other reinforcing signals deeply affect the outcome of metabolic function under CJL. Such features should be taken into account in further studies of shift working schedules in humans.

show abstract

Activity rhythm of golden hamster (Mesocricetus auratus) can be entrained to a 19-h light-dark cycle

Cited by 10 publications

References 66 publications

Effects of the Duper Mutation on Responses to Light

Effects of the Duper Mutation on Responses to Light

Simple Lighting Manipulations Facilitate Behavioral Entrainment of Mice to 18-h Days

Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice

Contact Info

Product

Resources

About