Activity test of various mangosteen (Garcinia mangostana) pericarp extract fractions to decrease fasting blood cholesterol levels and lipid peroxidation activity in diabetic mice

Husen, Saikhu Akhmad; Winarni, Dwi; Khaleyla, Firas; Kalqutny, Septian Hary

doi:10.23869/bphjbr.22.1.20163

Cited by 8 publications

(11 citation statements)

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“…Administering ethanolic extract of G. mangostana pericarp also lowers triglycerides, LDL, VLDL, and total cholesterol levels [16]. Because ethanol is a polar solvent, this result is in line with another study that showed that nonpolar and semipolar fractions of mangosteen pericarp extract did not reduce fasting cholesterol level in STZ-induced diabetic rats, whereas the polar extract produced a significant reduction [23]. One clinical study also showed a significant increase in HDL cholesterol in the mangosteen-treated group after 26 w, indicating a protective effect against cardiovascular risk in patients with type-2 DM [22].…”

Section: Effect On Lipid Profilesupporting

confidence: 83%

“…Malondialdehyde (MDA) is an end-product of lipid peroxidation and can thus be used as an indicator of cell or tissue damage caused by lipid peroxidation activity. Nonpolar, semipolar, and polar fractions of mangosteen pericarp extract have shown significant effects in decreasing serum MDA levels in rats with STZ-induced type-2 DM [23]. The group of diabetic rats treated with α-mangostin showed restoration of endogenous antioxidant enzymes to near-normal levels.…”

Section: Effect As Antioxidantmentioning

confidence: 94%

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Potential Holistic Preventive and Therapeutic Effects of Garcinia Mangostana Extract or Isolates in Type 2 Diabetes Mellitus: A Review

et al. 2019

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Objective: The need for long-term medication in diabetes mellitus has led to a search for herbal medicines as alternative treatments. Several studies have shown that extract or isolates of Garcinia mangostana can help prevent and treat type 2 diabetes mellitus (T2DM). Methods: This review was conducted by searching various databases, including PubMed, ClinicalKey, ScienceDirect, and EBSCOhost. We analyzed papers published within the previous 10 y. Results: All in vitro, in vivo, and clinical studies that evaluated the pharmacological effects of extract or isolates of G. mangostana in T2DM were reviewed. G. mangostana was found to suppress adipogenesis and regulate lipid homeostasis, thus improving lipid profiles and preventing T2DM. G. mangostana also demonstrated hypoglycemic properties, including the ability to decrease fasting blood glucose and mildly increase pancreatic β-cell numbers and activity. The mangosteen-treated group in one study showed a decrease in Homeostatic Model Assesment for Insulin Resistance (HOMA-IR), indicating improved insulin sensitivity, along with a significant decrease in the high-sensitivity CRP (hs-CRP) levels. Histopathology showed that the α-mangostin-treated group had less damage to pancreatic β cells, healthier hepatocytes and central veins, and less glomerular and tubular epithelial necrosis than the diabetic control group. Moreover, the antioxidant effect of G. mangostana was shown to protect against the micro-and macrovascular damage caused by T2DM. Conclusion: Extract or isolates of G. mangostana possess strong potential to prevent and treat T2DM. Further research evaluating long-term outcome biomarkers in humans is needed to confirm the drug’s glycemic control capacity.

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Section: Effect On Lipid Profilesupporting

confidence: 83%

Section: Effect As Antioxidantmentioning

confidence: 94%

Potential Holistic Preventive and Therapeutic Effects of Garcinia Mangostana Extract or Isolates in Type 2 Diabetes Mellitus: A Review

et al. 2019

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“…This condition indicates that STZ as an oxidant agent is capable of destroying pancreatic islet β-cells, which leads to the decrease of insulin production. Therefore, it generates an increased level of fasting blood glucose (Husen et al, 2016). Meanwhile, on the blood cholesterol levels, the STZ injection was also able to increase the mice's blood cholesterol level significantly from a mean of 152.40±24.294 before injection to 167.000±27.325 after injection.…”

Section: Resultsmentioning

confidence: 95%

“…Beside the prolonged hyperglycemic conditions, one of the factors which causes DM is obesity due to the increased levels of fat in the body caused by hyperlipidemic and escalating levels of cholesterol in the blood (Husen et al, 2016;Husen et al, 2017a). The increased blood cholesterol levels can be followed by the dilated levels of free fatty acids, which generate the enlarged superoxide production by mitochondria and the higher risk of cell exposure by the reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Alpha-mangostin in Glucose Level, Cholesterol Level, and Diameter of the Islets of Langerhans of STZ-induced Diabetic Mice

Husen

Salamun

Ansori

et al. 2018

Proceedings of the 2nd International Conference Postgraduate School

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The increasing prevalence of Diabetes Mellitus (DM) worldwide is an issue of major socioeconomic concern. DM is a complex and a multifarious group of disorders that disturbs the metabolism of carbohydrates, fat, and protein. Medicinal plants play an important role in the management of DM, especially in developing countries. The aim of this study is to investigate the antidiabetic and antilipidemic effects of alpha-mangostin in STZ-induced diabetic mice. We conducted the study using the male BALB/C mice. The mice were divided into two groups: the normal control (KN) and the STZ-induced diabetic mice. Streptozotocin (STZ) induction was performed using multiple low-doses of 30 mg/kg bw injected for five consecutive days. The diabetic mice were grouped again into three subgroups: diabetic control (KD), metformin HCL treated diabetic mice (KM), and diabetic mice which were treated using alpha-mangostin at 2 mg/kg bw (P1), 4 mg/kg bw (P2), and 8 mg/kg bw (P3). Before and after STZ injection, the blood glucose and the cholesterol levels were observed. The blood glucose and the cholesterol levels were also measured on the 1 st , 7 th , and 14 th day of alpha-mangostin treatments. Treatment was given for 14 days. At the 15 th day, the pancreases were collected and then processed into histological slides. The results of this experimental study indicated that alpha-mangostin has hypoglycemic and hypolipidemic activities which can ameliorate the damaged islets of Langerhans in STZ-induced diabetic mice. Therefore, we concluded that alphamangostin is a promising antidiabetic and antilipidemic agent due to its antioxidant activity.

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“…In addition, STZ also could activate reactive oxygen that plays an important role in cellular damage [22]. Free radicals ROS and RNS could disrupt the physiological function of various tissues and possibly caused damage in the kidney.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Activity Assay of Alpha-mangostin for Amelioration of Kidney Structure and Function in Diabetic Mice

Husen¹,

Khaleyla²,

Ansori³

et al. 2018

Proceedings of the 1st International Conference Postgraduate School Universitas Airlangga : "Implementation of Climate Change A

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Abstract-This research was aimed to investigate the ability of a alpha-mangostin compound derived from mangosteen pericarp to reduce plasma blood urea nitrogen (BUN) and creatinine level, and also to ameliorate the damaged renal proximal tubular of the kidneys in diabetic mice. An in-vivo antioxidant test was conducted using male BALB/c mice. The mice were divided into two groups; normal control (KN) and streptozotocin-induced diabetic mice. Streptozotocin (STZ) induction was performed using multiple low-doses of 30 mg/kg injected for five consecutive days. The diabetic mice were separated again into three sub-groups; diabetic control (KD), diabetic mice treated with Metformin HCl (KM), and diabetic mice treated with alpha-mangostin. The alpha-mangostin treatment group was categorised based on the dose given; P1 (2 mg/kg body weight), P2 (4 mg/kg body weight) and P3 (8 mg/kg body weight). Before and after STZ injection, the body weight and fasting blood glucose were measured. The body weight and fasting blood glucose were measured on the 1 st , 7 th , and 14 th day of alpha-mangostin treatment. Alpha-mangostin was given orally for 14 days. On the 15 th day, the plasma BUN and creatinine level were measured using Pentra C 200. Interestingly, the administration of alpha-mangostin was able to lower the plasma BUN and creatinine level, and also the ameliorate-damaged renal proximal tubular epithelial cells of the kidney in diabetic mice leseened significantly.

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Activity test of various mangosteen (Garcinia mangostana) pericarp extract fractions to decrease fasting blood cholesterol levels and lipid peroxidation activity in diabetic mice

Cited by 8 publications

References 0 publications

Potential Holistic Preventive and Therapeutic Effects of Garcinia Mangostana Extract or Isolates in Type 2 Diabetes Mellitus: A Review

Potential Holistic Preventive and Therapeutic Effects of Garcinia Mangostana Extract or Isolates in Type 2 Diabetes Mellitus: A Review

The Effect of Alpha-mangostin in Glucose Level, Cholesterol Level, and Diameter of the Islets of Langerhans of STZ-induced Diabetic Mice

Antioxidant Activity Assay of Alpha-mangostin for Amelioration of Kidney Structure and Function in Diabetic Mice

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