ACTN3 Gene R577X Polymorphism Associated with High-Density Lipoprotein Cholesterol and Adiponectin in Rugby Players

Nirengi, Shinsuke; Fujibayashi, Mami; Tsuzaki, Kokoro; Furuno, Sachiko; Uchibe, Akihiko; Kawase, Yasuharu; Kotani, Kazuhiko; Sakane, Naoki

doi:10.4158/ep15963.or

Cited by 11 publications

(11 citation statements)

References 33 publications

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“…Changing in HDL-C in human is certainly under genetic infl uence (Kim & Lee 2013;Nirengi et al 2016;Bandarian et al 2016). Actually, the changes of HDL-C is a latent variable.…”

Section: Resultsmentioning

confidence: 99%

“…Because of the frequent confounding of low HDL-C with hypertriglyceridemia, it has been argued that low HDL-C is an innocent bystander of (postprandial) hypertriglyceridemia or another culprit related to insulin resistance or infl ammation, (Gordon et al 1977;Silventoinen et al 2007). Genetic association of HDL-C is demonstrated in some population, (Kim & Lee 2013;Nirengi et al 2016;Bandarian et al 2016).…”

Section: Introductionmentioning

confidence: 99%

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Association of gene variants with longitudinal changes in high density lipoprotein cholesterol among Tehranian People: A latent growth curve model

Akbarzadeh¹,

Moghimbeigi²,

Morris³

et al. 2017

Biosci. Biotech. Res. Comm

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High density lipoprotein cholesterol (HDL-C) particles remove fat molecules from cells which need to export fat molecules. The aim of this study was to assess the association of SNP related to fat mass and obesity associated gene (FTO) with HDL-C change in a subset of participated families in Tehran Lipid and Glucose Study (TLGS). In this study 914 individual (with age>3) including 126 families with size 8.49±3.10 were selected from participants in TLGS. Genomic DNA was extracted from peripheral blood using standard salting-out method. HDL-C measured in four time point from March 1999 to December 2011 with a 3-year follow-up period. We examine the association via a latent growth curve model. To achieve the study target we used the latent growth curve model (LGCM) in R in TLGS family data. Adjusted association by sex and age between some FTO genes and changes of HDL-C overtime are signifi cant. Our fi ndings provide basis for searching for genes affecting change in HDL-C.

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“…Changing in HDL-C in human is certainly under genetic infl uence (Kim & Lee 2013;Nirengi et al 2016;Bandarian et al 2016). Actually, the changes of HDL-C is a latent variable.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of gene variants with longitudinal changes in high density lipoprotein cholesterol among Tehranian People: A latent growth curve model

Akbarzadeh¹,

Moghimbeigi²,

Morris³

et al. 2017

Biosci. Biotech. Res. Comm

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“…One meta-analysis has demonstrated that the ACE D allele has some selective advantages that contribute to longevity in the majority of European populations [ 45 ]. Another study on rugby players found that the ACTN3 X allele was related to higher high-density lipoprotein levels with known cardioprotective effects [ 46 ]. On the other hand, other studies showed that carriers of the ACE D polymorphism had a higher risk of myocardial infarction, and the ACTN3 X allele was associated with a higher risk of developing insulin resistance, which is a known factor of increased mortality [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Goalkeepers Live Longer than Field Players: A Retrospective Cohort Analysis Based on World-Class Football Players

Śmigielski

Gajda²,

Małek

et al. 2020

IJERPH

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The purpose of this article is to study whether the position occupied by footballers on the pitch influences their life duration. It is known that various types of sporting activity (endurance, resistance, or mixed) may influence lifespan in different ways. However, there is a paucity of data regarding the role of different positions played in team sports such as football. Our research was based on elite international football players born before 1923 who took part in the first three football World Cups (n = 443) or played in the 1946/1947 season in the leading clubs of the main European leagues (n = 280). Goalkeepers were characterized by a 5–8-year longer life duration compared to their colleagues playing in other positions (World Cup: 82.0 ± 7.0 vs. 74.0 ± 8.0, p = 0.0047; European leagues: 83.0 ± 7.5 vs. 78.0 ± 8.0, p = 0.0023), with an absence of differences between defenders, midfielders, and forwards. Moreover, in both of the analyzed subgroups, the rate of survival until the 85th birthday was significantly higher among goalkeepers than among field players (p = 0.0102 and p = 0.0048, for both studied groups, respectively).

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“…Serum adiponectin levels were significantly higher in X/X genotype than R/R or R/X genotype of α-actinin-3 (ACTN3) in rugby players (30). This may be useful information when determining the individual responses of anti-atherogenic markers to exercise.…”

Section: Sažetakmentioning

confidence: 96%

Effects of exercise on plasma adiponectin levels in athletes

Popovic¹,

Nešić²

2016

Medicinski podmladak

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Adipose tissue is an endocrine organ which releases biologically active adipokines. Adiponectin, an adipocyte-derived protein structurally similar to complement 1q, plays a significant role in metabolic disorders, due to its insulin sensitizing, anti-inflammatory and anti-atherogenic properties. AdipoR 1 and AdipoR 2 , mediate the metabolic actions of adiponectin by activating adenosine monophosphate-activated protein kinase (AMPK) and peroxisome proliferator-activated receptors-alpha (PPAR-α) which leads to an increase in fatty acid combustion and energy consumption, fatty acid oxidation and glucose uptake in myocytes and reduces gluconeogenesis and thus leads to increased insulin sensitivity. Plasma adiponectin level is affected by multiple factors: gender (females have higher plasma adiponectin levels), obesity-linked diseases (metabolic syndrom, diabetes mellitus type 2 and atherosclerosis are associated with lower adiponectin levels), lifestyle -including exercise. Yet, to date, little is known about the response of adiponectin concentrations to exercise and, in particular, the response of this hormone to training in population of athletes. The aim of this review is to overview the published evidence for the effects of exercise on adiponectin levels in athletes. Adiponectin concentration presents a delayed increase (30 min) after short-term intense performance, by athletes, both male and female. It seems that adiponectin concentrations do not change in response to long-term exercise. No significant difference was found in total adiponectin and/or high-molecular weight (HMW) oligomers in long-term effects of high physical training in athletes. Adiponectin can serve to monitor training loads and the establishment of individual limit values of training loads. Further studies are needed to clarify possible mechanisms by which adiponectin might influence energy homeostasis during heavy training in elite athletes. Key words: adiponectin, adipose tissue, athlets, exercise. SažetakMasno tkivo je endokrini organ, koji oslobađa biološki aktivne adipokine. Jedan od adipokina je adiponektin, protein strukturno sličan komplementu 1q, koji ima značajnu ulogu u metaboličkim poremećajima zbog antiinflamatornog dejstva, anti-aterogenih svojstava i dejstva na insulin. Receptori AdipoR 1 i AdipoR 2 posreduju metaboličko dejstvo adiponektina aktiviranjem adenozin-monofosfat aktivirane proteinkinaze (AMPK) i peroksizom proliferator aktiviranog receptora alfa (PPAR-α), što dovodi do povećanog katabolizma i oksidacije masnih kiselina, preuzimanja glukoze u miocitima, smanjenja glukoneogeneze i povećanja osetljivosti na insulin. Na nivoe adiponektina utiče više činilaca: pol (žene imaju više vrednosti adiponektina u plazmi), bolesti povezane sa gojaznošću (metabolički sindrom, tip 2 dijabetesa melitusa i ateroskleroza su povezane sa nižim vrednostima adiponektina) i način života (uključujući vežbanje). Do danas se ipak malo zna o uticaju rekretivnog vežbanja na nivoe adiponektina, a posebno o uticaju treninga na nivo adipo...

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ACTN3 Gene R577X Polymorphism Associated with High-Density Lipoprotein Cholesterol and Adiponectin in Rugby Players

Cited by 11 publications

References 33 publications

Association of gene variants with longitudinal changes in high density lipoprotein cholesterol among Tehranian People: A latent growth curve model

Association of gene variants with longitudinal changes in high density lipoprotein cholesterol among Tehranian People: A latent growth curve model

Goalkeepers Live Longer than Field Players: A Retrospective Cohort Analysis Based on World-Class Football Players

Effects of exercise on plasma adiponectin levels in athletes

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