2009
DOI: 10.1016/j.cell.2009.06.032
|View full text |Cite
|
Sign up to set email alerts
|

Actomyosin Is the Main Driver of Interkinetic Nuclear Migration in the Retina

Abstract: SummaryProgenitor cell nuclei in the rapidly expanding epithelium of the embryonic vertebrate central nervous system undergo a process called interkinetic nuclear migration (IKNM). Movements of IKNM are generally believed to involve smooth migration of nuclei from apical to basal and back during the G1 and G2 phases of the cell cycle, respectively. Yet, this has not been formally demonstrated, nor have the molecular mechanisms that drive IKNM been identified. Using time-lapse confocal microscopy to observe nuc… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

27
339
3

Year Published

2011
2011
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 241 publications
(369 citation statements)
references
References 30 publications
27
339
3
Order By: Relevance
“…A recent study identified cortical actin filaments at the back of the cell that can generate pushing forces at the rear of the nucleus that may facilitate transmigration (38). To investigate the role of forces acting on the rear of the nucleus, we dissected the influence of push and pull forces and tested whether push forces acting on the rear of the nucleus can explain the shape and distribution of strain during transmigration.…”
Section: Pulling Forces As the Primary Mechanism Of Transmigrationmentioning
confidence: 99%
“…A recent study identified cortical actin filaments at the back of the cell that can generate pushing forces at the rear of the nucleus that may facilitate transmigration (38). To investigate the role of forces acting on the rear of the nucleus, we dissected the influence of push and pull forces and tested whether push forces acting on the rear of the nucleus can explain the shape and distribution of strain during transmigration.…”
Section: Pulling Forces As the Primary Mechanism Of Transmigrationmentioning
confidence: 99%
“…The majority of Ki67 [+] cells localized to the apical side (next to the RPE layer). Such distribution is typical for cells in the M-phase undergoing interkinetic nuclear migration in vertebrate retinogenesis [62][63][64][65][66][67]. It is also characteristic of Mstage dividing progenitors in other types of developing stratified neuroepithelia [68].…”
Section: Evidence Of Subdivision Of 3d Retina-like Tissue Into Outer mentioning
confidence: 99%
“…We found a large number of strongly positive PAX6 [+] cells near the apical side of hESC-derived retinal tissue. The apical side of embryonic mammalian retina contains progenitors [62,63], where they acquire cell fate after the last mitotic cycle and migrate into the retinal layers to undergo maturation. The majority of CRX [+] cells were also localized to the apical side of hESC-derived retinal tissue.…”
Section: Figmentioning
confidence: 99%
“…Their differentiation capacity gradually changes as retinogenesis proceeds; they have a tendency to produce ganglion cells and cones at early stages, and then rods and bipolar cells at late stages 6,7 . Like cortical progenitors, these NR progenitors show the radial glia-like morphology with thin apical and basal processes, characteristic of neuroepithelial progenitors, and they undergo interkinetic nuclear migration during mitotic cycles 8,9 . (Hereafter, these progenitors are referred to as 'NR progenitors').…”
mentioning
confidence: 99%