Actual immunization coverage throughout Europe: are existing data sufficient?

Lopalco, Pietro Luigi; Santisteve, Paloma Carrillo

doi:10.1111/1469-0691.12453

Cited by 14 publications

(10 citation statements)

References 6 publications

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“…The European Centre for Disease Prevention and Control (ECDC) as well as the VENICE project keep track on vaccination rates in different EU member states (VENICE II Consortium, 2012, Lopalco and Carrillo, 2014). According to ECDC, German vaccination rates are lower than in many other European countries (VENICE II Consortium, 2011).…”

Section: Introductionmentioning

confidence: 99%

Educating parents about the vaccination status of their children: A user-centered mobile application

Seeber

Conrad

Hoppe

et al. 2017

Preventive Medicine Reports

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Parents are often uncertain about the vaccination status of their children. In times of vaccine hesitancy, vaccination programs could benefit from active patient participation. The Vaccination App (VAccApp) was developed by the Vienna Vaccine Safety Initiative, enabling parents to learn about the vaccination status of their children, including 25 different routine, special indication and travel vaccines listed in the WHO Immunization Certificate of Vaccination (WHO-ICV). Between 2012 and 2014, the VAccApp was validated in a hospital-based quality management program in Berlin, Germany, in collaboration with the Robert Koch Institute. Parents of 178 children were asked to transfer the immunization data of their children from the WHO-ICV into the VAccApp. The respective WHO-ICV was photocopied for independent, professional data entry (gold standard). Demonstrating the status quo in vaccine information reporting, a Recall Group of 278 parents underwent structured interviews for verbal immunization histories, without the respective WHO-ICV. Only 9% of the Recall Group were able to provide a complete vaccination status; on average 39% of the questions were answered correctly. Using the WHO-ICV with the help of the VAccApp resulted in 62% of parents providing a complete vaccination status; on average 95% of the questions were answered correctly. After using the VAccApp, parents were more likely to remember key aspects of the vaccination history. User-friendly mobile applications empower parents to take a closer look at the vaccination record, thereby taking an active role in providing accurate vaccination histories. Parents may become motivated to ask informed questions and to keep vaccinations up-to-date.

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Section: Introductionmentioning

confidence: 99%

Educating parents about the vaccination status of their children: A user-centered mobile application

Seeber

Conrad

Hoppe

et al. 2017

Preventive Medicine Reports

View full text Add to dashboard Cite

show abstract

“…In Europe, only Denmark, Iceland, Malta, the Netherlands, and Norway have a national, fully implemented digital IIS, while six other countries have subnational IISs ( 7 ). Among the systems adopted by these countries, there is a high variability in methods, frequency of data acquisition, geographic coverage, data storage, and distribution ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…Initial efforts are being made to build digital registries at the international level, in order to facilitate global surveillance of vaccination programs and sharing of good practices. A system with such characteristics has been implemented by WHO and UNICEF: the Centralized Information System for Infectious Diseases ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

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Can Digital Tools Be Used for Improving Immunization Programs?

Tozzi

Gesualdo

D’Ambrosio

et al. 2016

Front. Public Health

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In order to successfully control and eliminate vaccine-preventable infectious diseases, an appropriate vaccine coverage has to be achieved and maintained. This task requires a high level of effort as it may be compromised by a number of barriers. Public health agencies have issued specific recommendations to address these barriers and therefore improve immunization programs. In the present review, we characterize issues and challenges of immunization programs for which digital tools are a potential solution. In particular, we explore previously published research on the use of digital tools in the following vaccine-related areas: immunization registries, dose tracking, and decision support systems; vaccine-preventable diseases surveillance; surveillance of adverse events following immunizations; vaccine confidence monitoring; and delivery of information on vaccines to the public. Subsequently, we analyze the limits of the use of digital tools in such contexts and envision future possibilities and challenges.

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“…Of note, the frequent replacements between EV-As have been observed over the last decade in the regions where HFMD is endemic [ 2 – 6 ]. In recent years CV-A6 has emerged and replaced CV-A16 to become the dominant EV-A detected in HFMD patients [ 7 , 8 ]. While the underlying mechanism of this phenomenon remains unknown, the data highlight the importance of continued effort to monitor the evolution of the causative agents of HFMD.…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of a non-ribosomal random PCR and next-generation sequencing based assay for detection and sequencing of hand, foot and mouth disease pathogens

Nguyen

Tran

Van

et al. 2016

Virol J

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BackgroundHand, foot and mouth disease (HFMD) has become a major public health problem across the Asia-Pacific region, and is commonly caused by enterovirus A71 (EV-A71) and coxsackievirus A6 (CV-A6), CV-A10 and CV-A16. Generating pathogen whole-genome sequences is essential for understanding their evolutionary biology. The frequent replacements among EV serotypes and a limited numbers of available whole-genome sequences hinder the development of overlapping PCRs for whole-genome sequencing.We developed and evaluated a non-ribosomal random PCR (rPCR) and next-generation sequencing based assay for sequence-independent whole-genome amplification and sequencing of HFMD pathogens. A total of 16 EV-A71/CV-A6/CV-A10/CV-A16 PCR positive rectal/throat swabs (Cp values: 20.9–33.3) were used for assay evaluation.ResultsOur assay evidently outperformed the conventional rPCR in terms of the total number of EV-A71 reads and the percentage of EV-A71 reads: 2.6 % (1275/50,000 reads) vs. 0.1 % (31/50,000) and 6 % (3008/50,000) vs. 0.9 % (433/50,000) for two samples with Cp values of 30 and 26, respectively. Additionally the assay could generate genome sequences with the percentages of coverage of 94–100 % of 4 different enterovirus serotypes in 73 % of the tested samples, representing the first whole-genome sequences of CV-A6/10/16 from Vietnam, and could assign correctly serotyping results in 100 % of 24 tested specimens. In all but three the obtained consensuses of two replicates from the same sample were 100 % identical, suggesting that our assay is highly reproducible.ConclusionsIn conclusion, we have successfully developed a non-ribosomal rPCR and next-generation sequencing based assay for sensitive detection and direct whole-genome sequencing of HFMD pathogens from clinical samples.Electronic supplementary materialThe online version of this article (doi:10.1186/s12985-016-0580-9) contains supplementary material, which is available to authorized users.

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Actual immunization coverage throughout Europe: are existing data sufficient?

Cited by 14 publications

References 6 publications

Educating parents about the vaccination status of their children: A user-centered mobile application

Educating parents about the vaccination status of their children: A user-centered mobile application

Can Digital Tools Be Used for Improving Immunization Programs?

Development and evaluation of a non-ribosomal random PCR and next-generation sequencing based assay for detection and sequencing of hand, foot and mouth disease pathogens

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